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Ionis Pharmaceuticals

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

Yi Chen^*1, Curt Mazur^*2, Yi Luo^*1, Linhong Sun¹, Mingdi Zhang¹, Alex McCampbell¹, Giulio Srubek Tomassy¹

Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.