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Philip Morris Research Laboratories Pte. Ltd.

1 ARTICLES PUBLISHED IN JoVE

Engineering

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies

Didier Goedertier¹, Sandra Schorderet Weber¹, Francesco Lucci¹, Tom Lee², Wei Teck Tan², Falk Radtke¹, Subash Krishnan², Patrick Vanscheeuwijck¹, Arkadiusz K. Kuczaj^1,3, Julia Hoeng¹

¹PMI R&D, Philip Morris Products S.A., ²PMI R&D, Philip Morris Research Laboratories Pte. Ltd., ³Applied Mathematics, University of Twente

The protocol describes the settings and use of a capillary aerosol generator for continuous production of controlled aerosol from a multispecies liquid solution, suitable for steady large-volume aerosol delivery (e.g., in vivo inhalation studies).