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Erasmus MC University Medical Center Rotterdam

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

The Preparation of Chicken Ex Ovo Embryos and Chorioallantoic Membrane Vessels as In Vivo Model for Contrast-Enhanced Ultrasound Imaging and Microbubble-Mediated Drug Delivery Studies

Bram Meijlink¹, Ilya Skachkov¹, Antonius F. W. van der Steen^1,2, Nico de Jong^1,2, Klazina Kooiman¹

¹Department of Biomedical Engineering, Thoraxcenter, Erasmus MC University Medical Center Rotterdam, ²Laboratory of Acoustical Wavefield Imaging, Faculty of Applied Sciences, Delft University of Technology

This protocol describes three methods on how to obtain and use 5 to 8-day old chicken embryos and their chorioallantoic membrane (CAM) as an in vivo model to study contrast-enhanced ultrasound imaging and microbubble-mediated drug delivery.