A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.Babak Saravi *1,2, Gernot Lang *2, Sibylle Grad 1, Mauro Alini 1, R. Geoff Richards 1,2, Hagen Schmal 2, Norbert Südkamp 2, Zhen Li 1
1AO Research Institute Davos, Davos, Switzerland, 2Department of Orthopedics and Trauma Surgery, Medical Centre-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany
This protocol presents a novel experimental model of proinflammatory, degenerative bovine organ culture to simulate early-stage intervertebral disc degeneration.
