An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection SurgeryJulia A. Dubowitz 1,2,3, Fabian Jost-Brinkmann 1,4,5, Alexandra I. Ziegler 1, Ryan D. Gillis 1, Bernhard Riedel 1,2,3,6, Erica K. Sloan 1,2
1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, 2Department of Anaesthesia, Division of Cancer Surgery, Peter MacCallum Cancer Centre, 3Department of Critical Care, Melbourne Medical School, University of Melbourne, 4Medical Department, Division of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, 5Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 6Sir Peter MacCallum Department of Oncology, University of Melbourne
This paper describes a method for modeling total intravenous anesthesia (TIVA) during cancer resection surgery in mice. The goal is to replicate key features of anesthesia delivery to patients with cancer. The method allows investigation of how anesthetic technique affects cancer recurrence after resection surgery.
