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the First Affiliated Hospital, Jinan University

4 ARTICLES PUBLISHED IN JoVE

Medicine

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Xiaohui Li^*1,2, Weijiang Tan^*1,3, Xiang Li^*1, Shuang Zheng^*1, Xiaoshen Zhang², Honghua Chen¹, Zhanhong Pan¹, Caiyi Zhu¹, Feng Hua Yang¹

¹Guangdong Laboratory Animals Monitoring Institute, ²Department of Cardiovascular Surgery, the First Affiliated Hospital, Jinan University, ³College of Veterinary Medicine, South China Agricultural University

The present protocol describes a step-by-step procedure to establish a minipig model of heart failure with preserved ejection fraction using descending aortic constriction. The methods for evaluating cardiac morphology, histology, and function of this disease model are also presented.

Medicine

Establishment and Evaluation of a Porcine Vein Graft Disease Model

Xiaohui Li^*1, Jinlin Hu^*1, Weijiang Tan^*2, Zhaoming Lin^*1, Caiyi Zhu², Chengfeng Huang¹, Jiawen Huang³, Yintian Liu¹, Qiuying Liao¹, Hua Lu¹, Xiaoshen Zhang¹

¹Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, ²Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, ³The First Affiliated Hospital of Jinan University

In this protocol, novel pig vein bypass grafting was performed through a small incision in the left chest wall without cardiopulmonary bypass. A postoperative pathology study was done, which showed intimal thickening.

Medicine

Laparoscopic Posterior Radical Antegrade Modular Pancreatosplenectomy for Distal Pancreatic Carcinoma

Junjie Liang^*1, Quan Jiang^*1, Leyang Xiang^*1, Yuchuan Jiang^1,2, Jiexing Li¹, Zhilong Liu¹, Qiang Li¹, Mingrong Cao¹, Youzhu Hu^1,3, Jian Sun¹

¹Department of Hepatobiliary Surgery, The First Affiliated Hospital, Jinan University, ²Department of Gastroenterology, The Second Affiliated Hospital, Nanchang University, ³Department of General Surgery, The Affiliated Shunde Hospital, Jinan University

Laparoscopic radical antegrade modular pancreatosplenectomy (L-RAMPS) is currently considered technically safe and feasible. However, due to technical challenges and a lack of supporting evidence for widespread clinical applications, only a limited number of institutions are currently conducting L-RAMPS. This article aims to provide detailed techniques for laparoscopic posterior radical antegrade modular pancreatosplenectomy.

Medicine

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Qiang Li^*1, Xiaolan Wang^*1,2, Deju Li^*1, Yulong Liu^*3, Kangshou Liu¹, Junjie Liang¹, Jian Sun¹, Quan Jiang¹, Jiexing Li¹, Zhilong Liu¹, Jian Gong⁴, Leyang Xiang¹, Zhidong Jia¹, Zhiwei Chen¹, Mingrong Cao¹, Yuchuan Jiang^1,5

¹Department of Hepatobiliary Surgery, The First Affiliated Hospital, Jinan University, ²Dongpu Branch, The First Affiliated Hospital, Jinan University, ³Department of Vascular Intervention, The First Affiliated Hospital, Jinan University, ⁴Department of Nuclear Medicine, The First Affiliated Hospital, Jinan University, ⁵Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University

This study illustrates the methodological potential of combining Yttrium-90 Trans-Arterial Radioembolization (Y-90 TARE) with an anti-PD-1 monoclonal antibody as an effective neoadjuvant strategy leading to hepatectomy in hepatocellular carcinoma (HCC) patients with a high initial recurrence risk. It emphasizes the safety, feasibility, and step-by-step procedural guidance of this approach.