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Douglas Mental Health University Institute

3 ARTICLES PUBLISHED IN JoVE

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Neuroscience

Preparation of Mouse Brain Tissue for Immunoelectron Microscopy
Marie-Eve Tremblay 1, Mustapha Riad 2, Ania Majewska 1
1Department of Neurobiology and Anatomy, University of Rochester, 2Douglas Mental Health University Institute

We describe a protocol for transcardiac perfusion of mice, removal and sectioning of the brain, as well as immunoperoxidase staining, resin embedding, and ultrathin sectioning of the brain sections. Upon completion of these procedures, the immunostained material is ready for examination with transmission electron microscopy.

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Behavior

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Vivian Gu 1, Ola Mohamed Ali 1, Katherine L'Abbée Lacas 2, J. Bruno Debruille 3,4
1Department of Psychology, McGill University, 2Department of Cognitive Science, McGill University, 3Douglas Institute, Department of Psychiatry, McGill University, 4Neurology and Neurosurgery Department, McGill University

Using event-related EEG potentials (ERPs), we investigate the effects of antipsychotic medications on abnormal semantic brain activations in healthy individuals with schizotypal traits. We use ERPs to track distinct changes in brain activity, shedding insight into the cognitive processes associated with semantic categorization.

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Neuroscience

How to Find Effects of Stimulus Processing on Event Related Brain Potentials of Close Others when Hyperscanning Partners
Amanda Tardif 1,3, Ashley Chau-Morris 1,2, Zi Yue Wang 1, Ehime Takahara 1, Tim Hadjis 1,2, Jean Debruille 1, J. Bruno Debruille 1,2,3
1Douglas Mental Health University Institute, 2Department of Psychiatry, McGill University, 3Department of Neurology and Neurosurgery, McGill University

This protocol describes key steps involved in assessing the sensitivity of the brain of one person to the stimulus processing of a close other by selecting pairs of partners, recording their electroencephalogram (EEG) simultaneously and computing their event-related brain potentials (ERPs).

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