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Douglas Mental Health University Institute

3 ARTICLES PUBLISHED IN JoVE

Neuroscience

Preparation of Mouse Brain Tissue for Immunoelectron Microscopy

Marie-Eve Tremblay¹, Mustapha Riad², Ania Majewska¹

¹Department of Neurobiology and Anatomy, University of Rochester, ²Douglas Mental Health University Institute

We describe a protocol for transcardiac perfusion of mice, removal and sectioning of the brain, as well as immunoperoxidase staining, resin embedding, and ultrathin sectioning of the brain sections. Upon completion of these procedures, the immunostained material is ready for examination with transmission electron microscopy.

JoVE Core

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Vivian Gu¹, Ola Mohamed Ali¹, Katherine L'Abbée Lacas², J. Bruno Debruille^3,4

¹Department of Psychology, McGill University, ²Department of Cognitive Science, McGill University, ³Douglas Institute, Department of Psychiatry, McGill University, ⁴Neurology and Neurosurgery Department, McGill University

Using event-related EEG potentials (ERPs), we investigate the effects of antipsychotic medications on abnormal semantic brain activations in healthy individuals with schizotypal traits. We use ERPs to track distinct changes in brain activity, shedding insight into the cognitive processes associated with semantic categorization.

Neuroscience

How to Find Effects of Stimulus Processing on Event Related Brain Potentials of Close Others when Hyperscanning Partners

Amanda Tardif^1,3, Ashley Chau-Morris^1,2, Zi Yue Wang¹, Ehime Takahara¹, Tim Hadjis^1,2, Jean Debruille¹, J. Bruno Debruille^1,2,3

¹Douglas Mental Health University Institute, ²Department of Psychiatry, McGill University, ³Department of Neurology and Neurosurgery, McGill University

This protocol describes key steps involved in assessing the sensitivity of the brain of one person to the stimulus processing of a close other by selecting pairs of partners, recording their electroencephalogram (EEG) simultaneously and computing their event-related brain potentials (ERPs).