Nicholas A. Vitanza

Ben Towne Center for Childhood Cancer Research

Seattle Children’s Research Institute

BIOGRAPHY

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PUBLICATIONS

Immunotherapy for brain tumors: understanding early successes and limitations.

Expert review of neurotherapeutics Mar, 2018 | Pubmed ID: 29322843

Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy.

Neuro-oncology Jan, 2019 | Pubmed ID: 30169876

Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials.

Current treatment options in neurology Jul, 2019 | Pubmed ID: 31290035

EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma.

Oncotarget Dec, 2019 | Pubmed ID: 31903167

Children with DIPG and high-grade glioma treated with temozolomide, irinotecan, and bevacizumab: the Seattle Children's Hospital experience.

Journal of neuro-oncology Jul, 2020 | Pubmed ID: 32556862

Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.

Neuro-oncology Mar, 2021 | Pubmed ID: 33130903

Considerations when treating high-grade pediatric glioma patients with immunotherapy.

Expert review of neurotherapeutics Feb, 2021 | Pubmed ID: 33225764

MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study.

Neuro-oncology advances , 2021 | Pubmed ID: 33977272

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.

Nature medicine Sep, 2021 | Pubmed ID: 34253928

Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.

Oncogene Jan, 2022 | Pubmed ID: 34759345

Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.

Neuro-oncology advances , 2021 | Pubmed ID: 34988452

Two cases of pineal anlage tumor with molecular analysis.

Pediatric blood & cancer Apr, 2022 | Pubmed ID: 35129878

Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.

Neuro-oncology Aug, 2022 | Pubmed ID: 35137228

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.

Neuro-oncology Sep, 2022 | Pubmed ID: 35157764

The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies.

Neuro-oncology Sep, 2022 | Pubmed ID: 35481923

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.

Cancer discovery Jan, 2023 | Pubmed ID: 36259971

Phase I dose escalation and expansion trial of single agent ONC201 in pediatric diffuse midline gliomas following radiotherapy.

Neuro-oncology advances , 2022 | Pubmed ID: 36382108

Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety.

Neoplasia (New York, N.Y.) Feb, 2023 | Pubmed ID: 36599192

Functional genomic analysis of adult and pediatric brain tumor isolates.

bioRxiv : the preprint server for biology Jan, 2023 | Pubmed ID: 36711964

INSTITUTIONS

Seattle Children’s Research Institute

University of Washington

JOVE ARTICLES

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice

Kyra Harvey¹,

Peter J. Madsen^2,3,

Tiffany Smith²,

Crystal Griffin^1,2,

Luke Patterson^1,2,

Nicholas A. Vitanza^4,5,

Phillip B. Storm^2,3,

Adam C. Resnick^2,3,

Jessica B. Foster^1,2

¹Division of Oncology, Children’s Hospital of Philadelphia,

²Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia,

³Division of Neurosurgery, Children’s Hospital of Philadelphia,

⁴Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute,

⁵Department of Pediatrics, Seattle Children’s Hospital, University of Washington

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Nicholas A. Vitanza

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Seattle Children’s Research Institute

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice

Ben Towne Center for Childhood Cancer Research