Replicating Glioblastoma Invasion with Hyaluronan-Collagen I Hydrogel System

October 18th 2024



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We present a method for replicating the glioma tumor microenvironment at the invasive front that incorporates interstitial fluid flow. This model is a hyaluronan-collagen I hydrogel in a tissue culture insert where a fluid pressure head can be applied. Invasion can be quantified, and cells can be isolated or lysed.

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