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Chapter 9

Трансляция: от РНК к белку

Перевод
Перевод
Lesson: Translation Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following ...
Активация тРНК
Активация тРНК
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 ...
Рибосомы
Рибосомы
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that ...
Улучшение точности трансляции
Улучшение точности трансляции
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single ...
Инициация трансляции
Инициация трансляции
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are ...
Остановка трансляции
Остановка трансляции
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the ...
Нонсенс-опосредованный распад мРНК
Нонсенс-опосредованный распад мРНК
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual ...
Молекулярные шапероны и сворачивание белков
Молекулярные шапероны и сворачивание белков
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form ...
Протеасома
Протеасома
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the ...
Регулируемая деградация белка
Регулируемая деградация белка
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a ...
Белки: от генов к деградации
Белки: от генов к деградации
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This ...
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