Войдите в систему

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.

On the other hand, the Loo-Riegelman method estimates ka by comparing plasma concentration-time profiles following different administration routes. It provides more comprehensive data, even for drugs with multicompartment characteristics, and aids in understanding drugs' relative bioavailability and absorption characteristics. Yet, it also has limitations, such as the concentration versus time data requirement for both oral and IV drug administration of the same subject and intra-subject between oral and IV administration studies.

Из главы 7:

article

Now Playing

7.9 : One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

Pharmacokinetic Models

176 Просмотры

article

7.1 : Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

Pharmacokinetic Models

46 Просмотры

article

7.2 : Model Approaches for Pharmacokinetic Data: Compartment Models

Pharmacokinetic Models

47 Просмотры

article

7.3 : One-Compartment Open Model for IV Bolus Administration: General Considerations

Pharmacokinetic Models

101 Просмотры

article

7.4 : One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

Pharmacokinetic Models

65 Просмотры

article

7.5 : One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

Pharmacokinetic Models

32 Просмотры

article

7.6 : One-Compartment Model: IV Infusion

Pharmacokinetic Models

102 Просмотры

article

7.7 : One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

Pharmacokinetic Models

34 Просмотры

article

7.8 : One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

Pharmacokinetic Models

129 Просмотры

article

7.10 : One-Compartment Open Model: Urinary Excretion Data and Determination of k

Pharmacokinetic Models

52 Просмотры

article

7.11 : Multicompartment Models: Overview

Pharmacokinetic Models

50 Просмотры

article

7.12 : Two-Compartment Open Model: Overview

Pharmacokinetic Models

62 Просмотры

article

7.13 : Two-Compartment Open Model: IV Bolus Administration

Pharmacokinetic Models

122 Просмотры

article

7.14 : Two-Compartment Open Model: IV Infusion

Pharmacokinetic Models

126 Просмотры

article

7.15 : Two-Compartment Open Model: Extravascular Administration

Pharmacokinetic Models

92 Просмотры

See More

JoVE Logo

Исследования

Образование

О JoVE

Авторские права © 2025 MyJoVE Corporation. Все права защищены