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Chapter 17

Pharmacotherapy of the Epilepsies

Arteries of the Lower Limbs
Arteries of the Lower Limbs
Epilepsy is a chronic neurological disorder characterized by recurrent, unpredictable seizures. Seizures result from abnormal electrical discharges in the ...
Seizures: Classification
Seizures: Classification
Epilepsy is a chronic neurological disorder characterized by unpredictable seizures. Seizures can be provoked by identifiable factors or occur ...
Antiepileptic Drugs: Sodium Channel Blockers
Antiepileptic Drugs: Sodium Channel Blockers
Antiepileptic drugs, essential in managing epilepsy, effectively prevent seizures by blocking the movement of sodium ions through channels in the ...
Antiepileptic Drugs: GABAergic Pathway Potentiators
Antiepileptic Drugs: GABAergic Pathway Potentiators
γ-aminobutyric acid or GABA pathway potentiators are drugs used to manage epilepsy by enhancing GABA neurotransmission, a critical inhibitory pathway ...
Antiepileptic Drugs: Calcium Channel Blockers
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers, primarily known for cardiovascular use, have also shown potential as antiepileptic drugs. They exert their effects by modulating ...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: Glutamate Antagonists
Glutamate is the primary excitatory neurotransmitter in the brain, essential for neuronal communication. It plays a crucial role in synaptic transmission, ...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
Antiepileptic drugs, like levetiracetam and brivaracetam, leverage the synaptic vesicle protein SV2A to mitigate seizures. SV2A is a transmembrane ...
Antiepileptic Drugs: Potassium Channel Activators
Antiepileptic Drugs: Potassium Channel Activators
The Antiepileptic drug ezogabine functions as a potassium channel activator by enhancing transmembrane potassium currents mediated by the KCNQ subtype of ...
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