In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.

LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the puffs of polytene chromosomes. The polytene puffs are composed of several parallel chromatids, whereas the loops of LBC consist of a single, double helix.

During the diplotene stage of meiosis prophase, LBCs decondense forming large chromosomes, approximately 30 times larger than regular mitotic chromosomes. The average length of LBC loops is 10-15 µm. In some cases, loops can be as large as 50-100 µm. Polymerase II transcribes the largest loops, and the smallest loops are transcribed by polymerase III.

LBCs are present in the oocytes of lower vertebrae, invertebrates, and birds. LBCs in all these organisms share similar structures and functions. Comparative genome studies of LBCs have shown that the length of side loop increases with the C-value, which is the total DNA content in the haploid set of an organism.

LBCs are studied for over a hundred years, yet, only a general structural idea of LBC is known. Recently, LBCs are used as model structures to study cytogenetic analysis and epigenetic regulation of chromatin structure and gene expression.