Hans Clevers

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice.

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

The kinase TNIK is an essential activator of Wnt target genes.

Eyeing up new Wnt pathway players.

Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade.

Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish.

In situ hybridization to identify gut stem cells.

Searching for adult stem cells in the intestine.

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Coexistence of quiescent and active adult stem cells in mammals.

MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

Active Wnt signaling in response to cardiac injury.

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.

Lineage tracing in the intestinal epithelium.

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.

Wnts as self-renewal factors: mammary stem cells and beyond.

Stem cells and cancer of the stomach and intestine.

TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice.

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.

Tissue-resident adult stem cell populations of rapidly self-renewing organs.

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.

Sox9 marks adult organ progenitors.

Tracking adult stem cells.

A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.

The cancer stem cell: premises, promises and challenges.

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.

Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.

Strategies for homeostatic stem cell self-renewal in adult tissues.

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.

Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

Stem cell self-renewal in intestinal crypt.

Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment.

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

Isolation and in vitro expansion of human colonic stem cells.

Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes.

Single-cell dissection of transcriptional heterogeneity in human colon tumors.

Single-molecule transcript counting of stem-cell markers in the mouse intestine.

Controlled gene expression in primary Lgr5 organoid cultures.

Cdx2 determines the fate of postnatal intestinal endoderm.

Method for estimating the single molecular affinity.

Neural stem cells for diabetes cell-based therapy.

Optimality in the development of intestinal crypts.

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

What does the concept of the stem cell niche really mean today?

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

The R-spondin protein family.

Wnt signaling, stem cells, and cancer of the gastrointestinal tract.

Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields.

In vitro expansion and transplantation of intestinal crypt stem cells.

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.

On the biomechanics of stem cell niche formation in the gut--modelling growing organoids.

Wnt/β-catenin signaling and disease.

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".

Rap2A links intestinal cell polarity to brush border formation.

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.

Crypt base columnar stem cells in small intestines of mice are radioresistant.

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.

Cell biology. The unusual case of Porcupine.

Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland.

Modulating WNT receptor turnover for tissue repair.

Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells.

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

Identifying the stem cell of the intestinal crypt: strategies and pitfalls.

The Paneth cell, caloric restriction, and intestinal integrity.

Primary mouse small intestinal epithelial cell cultures.

Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias.

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

Identification of a clonally expanding haematopoietic compartment in bone marrow.

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

Immunosurveillance against tetraploidization-induced colon tumorigenesis.

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Paneth cells: maestros of the small intestinal crypts.

Stem Cells: A unifying theory for the crypt.

SnapShot: the intestinal crypt.

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

Conversion of mature human β-cells into glucagon-producing α-cells.

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.

Regulation of stem cell therapies under attack in Europe: for whom the bell tolls.

Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

Lgr proteins in epithelial stem cell biology.

A functional CFTR assay using primary cystic fibrosis intestinal organoids.

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications.

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine.

Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors.

Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.

The intestinal crypt, a prototype stem cell compartment.

LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice.

Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

A gutsy approach to stem cells and signalling: an interview with Hans Clevers.

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Generation of L cells in mouse and human small intestine organoids.

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.

Generation of BAC transgenic epithelial organoids.

LGR5 positivity defines stem-like cells in colorectal cancer.

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.

TTC7A mutations disrupt intestinal epithelial apicobasal polarity.

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium.

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

Ovarian LGR5 is critical for successful pregnancy.

Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.

Retroviral gene expression control in primary organoid cultures.

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.

STRAD pseudokinases regulate axogenesis and LKB1 stability.

KLF5 regulates the integrity and oncogenicity of intestinal stem cells.

Organoid cultures for the analysis of cancer phenotypes.

A promoter-level mammalian expression atlas.

Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.

Loss of syntaxin 3 causes variant microvillus inclusion disease.

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.

Stem Cells Marked by the R-Spondin Receptor LGR5.

Polarizing intestinal epithelial cells electrically through Ror2.

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.

Paneth cells.

Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development.

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Glial origin of mesenchymal stem cells in a tooth model system.

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.

Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency.

Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Organoid cultures derived from patients with advanced prostate cancer.

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.

A20 controls intestinal homeostasis through cell-specific activities.

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Plasticity within stem cell hierarchies in mammalian epithelia.

Large-scale identification of coregulated enhancer networks in the adult human brain.

Targeting development of incretin-producing cells increases insulin secretion.

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Organoid models of human and mouse ductal pancreatic cancer.

Microbiota controls the homeostasis of glial cells in the gut lamina propria.

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.

Premigratory and migratory neural crest cells are multipotent in vivo.

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Efficient intracellular delivery of native proteins.

Sequential cancer mutations in cultured human intestinal stem cells.

Prospective derivation of a living organoid biobank of colorectal cancer patients.

Q&A: Hans Clevers. Banking on organoids.

Repairing organs: lessons from intestine and liver.

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.

SnapShot: Growing Organoids from Stem Cells.

Expanding intestinal stem cells in culture.

Development and application of human adult stem or progenitor cell organoids.

In Situ Hybridization to Identify Gut Stem Cells.

Single-cell messenger RNA sequencing reveals rare intestinal cell types.

Lgr4 Controls Specialization of Female Gonads in Mice.

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.

Pre-clinical Models of Pancreatic Ductal Adenocarcinoma.

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

Radical Sabbaticals.

The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system.

Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.

STEM CELLS. What is an adult stem cell?

Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals.

Reparative inflammation takes charge of tissue regeneration.

Organoid culture systems for prostate epithelial and cancer tissue.

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

Tissue-specific designs of stem cell hierarchies.

Modeling pancreatic cancer with organoids.

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.

CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids.

Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use.

Model organoids provide new research opportunities for ductal pancreatic cancer.

Modeling Development and Disease with Organoids.

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation.

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis.

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data.

Analysis of neural crest-derived clones reveals novel aspects of facial development.

Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding.

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

The Generation of Organoids for Studying Wnt Signaling.

Organoids: Modeling Development and the Stem Cell Niche in a Dish.

Tissue-specific mutation accumulation in human adult stem cells during life.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells.

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

Designer matrices for intestinal stem cell and organoid culture.

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.

IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2.

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.

Erratum: Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells.

Human tissues in a dish: The research and ethical implications of organoid technology.

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

CRISPR/Cas 9 genome editing and its applications in organoids.

WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.

Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels.

SARS-CoV-2 productively infects human gut enterocytes.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.

COVID-19: organoids go viral.

Primary Intestinal Epithelial Organoid Culture.

Mathematical model of colorectal cancer initiation.

Human-Derived Model Systems in Gynecological Cancer Research.

Establishment of patient-derived cancer organoids for drug-screening applications.

Cell fate specification and differentiation in the adult mammalian intestine.

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids.

Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver.

Author Correction: Establishment of patient-derived cancer organoids for drug-screening applications.

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

Derivation of snake venom gland organoids for in vitro venom production.

Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids.

Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.

Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.

The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19.

Exploring the human lacrimal gland using organoids and single-cell sequencing.

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.

Wnt signaling controls the phosphorylation status of beta-catenin.

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.

Identification of two novel regulated serines in the N terminus of beta-catenin.

Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.

Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.

Transcription factor target practice.

The intestinal stem cell.

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

Identification of primary MAFB target genes in multiple myeloma.

Wnt signaling, lgr5, and stem cells in the intestine and skin.

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.

Disease Modeling in Stem Cell-Derived 3D Organoid Systems.

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells.

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics.

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

Cancer stem cells revisited.

The Human Cell Atlas.

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche.

Imaging organoids: a bright future ahead.

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.

Defining Adult Stem Cells by Function, not by Phenotype.

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Intra-tumour diversification in colorectal cancer at the single-cell level.

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche.

Use and application of 3D-organoid technology.

Bioengineered bile ducts recapitulate key cholangiocyte functions.

Modelling Cryptosporidium infection in human small intestinal and lung organoids.

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures.

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling.

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.

Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids.

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Profiling proliferative cells and their progeny in damaged murine hearts.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis.

Mouse and human urothelial cancer organoids: A tool for bladder cancer research.

Tubuloids derived from human adult kidney and urine for personalized disease modeling.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

High-resolution 3D imaging of fixed and cleared organoids.

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.

Xenograft and organoid model systems in cancer research.

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues.

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids.

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy.

Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells.

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.

Organoids: Avatars for Personalized Medicine.

LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.

Snake Venom Gland Organoids.

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a -Deficient Dog Model of Metabolic Liver Disease.

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.

Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.

Mutational signature in colorectal cancer caused by genotoxic pks E. coli.

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing.

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies.

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies.

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine.

Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses.

Kidney Organoids and Tubuloids.

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses.

Fasting-mimicking diet and hormone therapy induce breast cancer regression.

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.

Intestinal Regeneration: Regulation by the Microenvironment.

LifeTime and improving European healthcare through cell-based interceptive medicine.

Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.

A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing.

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation.

Translation and Replication Dynamics of Single RNA Viruses.

Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.

SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival.

The Organoid Cell Atlas.

Tissue regeneration: Reserve or reverse?

National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration.

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.

Organoids and organs-on-chips: Insights into human gut-microbe interactions.

Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis.

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.

Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids.

Evidence generation and reproducibility in cell and gene therapy research: A call to action.

Disease modeling following organoid-based expansion of airway epithelial cells.

Intestinal organoid cocultures with microbes.

Single-cell Ribo-seq reveals cell cycle-dependent translational pausing.

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses.

Mycobacteria-host interactions in human bronchiolar airway organoids.

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.

Molecular characterization of Barrett's esophagus at single-cell resolution.

Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism.

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis.

Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.

RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.

BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states.

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.

Patient-derived micro-organospheres enable clinical precision oncology.

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant.

Uncovering the mode of action of engineered T cells in patient cancer organoids.

Rapid tissue prototyping with micro-organospheres.

Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.

Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy.

Patient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS glycolytic colorectal tumors.

Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation.

Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids.