Hans Clevers

Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht

Affiliated withUniversity Medical Centre Utrecht foundation Hubrecht Organoid Technology Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht

Research Area

Immunology and InfectionMedicineUnit 1BiologyCancer Research

Biography

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JoVE Journal Publications

Article Total : 4	Year
Publication title	2015
Publication title	2017
Publication title	2023
Publication title	2021

Other Publications

Article	Year
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer research\| PubMed ID: 20736363	2010
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell\| PubMed ID: 20887898	2010
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology\| PubMed ID: 20951138	2011
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Developmental cell\| PubMed ID: 19386264	2009
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology\| PubMed ID: 19450592	2009
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nature neuroscience\| PubMed ID: 19503085	2009
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology\| PubMed ID: 19549527	2009
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiological reviews\| PubMed ID: 19584313	2009
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast cancer research and treatment\| PubMed ID: 19593635	2010
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nature genetics\| PubMed ID: 19718028	2009
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19741146	2009
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. The Journal of clinical investigation\| PubMed ID: 19759516	2009
The kinase TNIK is an essential activator of Wnt target genes. The EMBO journal\| PubMed ID: 19816403	2009
Eyeing up new Wnt pathway players. Cell\| PubMed ID: 19837026	2009
Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. The Journal of biological chemistry\| PubMed ID: 19850932	2009
Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish. Zebrafish\| PubMed ID: 19929219	2009
In situ hybridization to identify gut stem cells. Current protocols in stem cell biology\| PubMed ID: 20049690	2010
Searching for adult stem cells in the intestine. EMBO molecular medicine\| PubMed ID: 20049728	2009
Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Disease models & mechanisms\| PubMed ID: 20075383	2010
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell stem cell\| PubMed ID: 20085740	2010
Coexistence of quiescent and active adult stem cells in mammals. Science (New York, N.Y.)\| PubMed ID: 20110496	2010
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biological chemistry\| PubMed ID: 20128690	2010
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell stem cell\| PubMed ID: 20144789	2010
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (New York, N.Y.)\| PubMed ID: 20223988	2010
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Molecular cell\| PubMed ID: 20227366	2010
Active Wnt signaling in response to cardiac injury. Basic research in cardiology\| PubMed ID: 20373104	2010
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology\| PubMed ID: 20417836	2010
Lineage tracing in the intestinal epithelium. Current protocols in stem cell biology\| PubMed ID: 20443207	2010
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology\| PubMed ID: 20542037	2010
Wnts as self-renewal factors: mammary stem cells and beyond. Cell stem cell\| PubMed ID: 20569681	2010
Stem cells and cancer of the stomach and intestine. Molecular oncology\| PubMed ID: 20598659	2010
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20696899	2010
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental cell\| PubMed ID: 20708588	2010
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nature communications\| PubMed ID: 20975679	2010
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO molecular medicine\| PubMed ID: 20976827	2010
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. The Journal of clinical investigation\| PubMed ID: 20978345	2010
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21041628	2010
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS biology\| PubMed ID: 21103407	2010
Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell stem cell\| PubMed ID: 21112561	2010
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature\| PubMed ID: 21113151	2011
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles. PloS one\| PubMed ID: 21152096	2010
Sox9 marks adult organ progenitors. Nature genetics\| PubMed ID: 21217637	2011
Tracking adult stem cells. EMBO reports\| PubMed ID: 21252944	2011
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt. PLoS computational biology\| PubMed ID: 21253562	2011
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. The EMBO journal\| PubMed ID: 21297579	2011
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21368212	2011
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. The Journal of cell biology\| PubMed ID: 21383077	2011
The cancer stem cell: premises, promises and challenges. Nature medicine\| PubMed ID: 21386835	2011
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell stem cell\| PubMed ID: 21419747	2011
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. Gastroenterology\| PubMed ID: 21459094	2011
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell\| PubMed ID: 21663791	2011
Actomyosin-mediated cellular tension drives increased tissue stiffness and Î²-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer cell\| PubMed ID: 21665151	2011
Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. Journal of proteome research\| PubMed ID: 21696214	2011
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology\| PubMed ID: 21704588	2011
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature\| PubMed ID: 21727895	2011
Stem cell self-renewal in intestinal crypt. Experimental cell research\| PubMed ID: 21787769	2011
Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment. Nature protocols\| PubMed ID: 21799490	2011
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PloS one\| PubMed ID: 21826198	2011
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology\| PubMed ID: 21889923	2011
Isolation and in vitro expansion of human colonic stem cells. Nature medicine\| PubMed ID: 21892181	2011
Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes. Nucleic acids research\| PubMed ID: 21914722	2012
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature biotechnology\| PubMed ID: 22081019	2011
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature cell biology\| PubMed ID: 22119784	2012
Controlled gene expression in primary Lgr5 organoid cultures. Nature methods\| PubMed ID: 22138822	2012
Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England)\| PubMed ID: 22190642	2012
Method for estimating the single molecular affinity. Analytical biochemistry\| PubMed ID: 22209736	2012
Neural stem cells for diabetes cell-based therapy. EMBO molecular medicine\| PubMed ID: 22238783	2011
Optimality in the development of intestinal crypts. Cell\| PubMed ID: 22304925	2012
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nature cell biology\| PubMed ID: 22388892	2012
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Molecular and cellular biology\| PubMed ID: 22393260	2012
What does the concept of the stem cell niche really mean today? BMC biology\| PubMed ID: 22405133	2012
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nature medicine\| PubMed ID: 22406745	2012
The R-spondin protein family. Genome biology\| PubMed ID: 22439850	2012
Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harbor perspectives in biology\| PubMed ID: 22474007	2012
Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields. Science signaling\| PubMed ID: 22494969	2012
In vitro expansion and transplantation of intestinal crypt stem cells. Gastroenterology\| PubMed ID: 22613623	2012
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. The EMBO journal\| PubMed ID: 22617424	2012
On the biomechanics of stem cell niche formation in the gut--modelling growing organoids. The FEBS journal\| PubMed ID: 22632461	2012
Wnt/β-catenin signaling and disease. Cell\| PubMed ID: 22682243	2012
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell\| PubMed ID: 22682247	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. The EMBO journal\| PubMed ID: 22692129	2012
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Molecular and cellular biology\| PubMed ID: 22778137	2012
Rap2A links intestinal cell polarity to brush border formation. Nature cell biology\| PubMed ID: 22797597	2012
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature\| PubMed ID: 22837003	2012
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology\| PubMed ID: 22841781	2012
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (New York, N.Y.)\| PubMed ID: 22855427	2012
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22893683	2012
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature\| PubMed ID: 22895187	2012
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology\| PubMed ID: 22922422	2012
Cell biology. The unusual case of Porcupine. Science (New York, N.Y.)\| PubMed ID: 22923569	2012
Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. The Journal of pathology\| PubMed ID: 22926799	2012
Modulating WNT receptor turnover for tissue repair. Nature biotechnology\| PubMed ID: 22965053	2012
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 22969042	2012
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell reports\| PubMed ID: 22999937	2012
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nature cell biology\| PubMed ID: 23000963	2012
Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell stem cell\| PubMed ID: 23040474	2012
The Paneth cell, caloric restriction, and intestinal integrity. The New England journal of medicine\| PubMed ID: 23075184	2012
Primary mouse small intestinal epithelial cell cultures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23097115	2013
Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias. Immunity\| PubMed ID: 23159221	2012
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS biology\| PubMed ID: 23185135	2012
Identification of a clonally expanding haematopoietic compartment in bone marrow. The EMBO journal\| PubMed ID: 23188081	2013
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell\| PubMed ID: 23260145	2012
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell\| PubMed ID: 23273993	2013
Immunosurveillance against tetraploidization-induced colon tumorigenesis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23324343	2013
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature\| PubMed ID: 23354049	2013
Intestinal regeneration: YAP-tumor suppressor and oncoprotein? Current biology : CB\| PubMed ID: 23391384	2013
Paneth cells: maestros of the small intestinal crypts. Annual review of physiology\| PubMed ID: 23398152	2013
Stem Cells: A unifying theory for the crypt. Nature\| PubMed ID: 23446347	2013
SnapShot: the intestinal crypt. Cell\| PubMed ID: 23452862	2013
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature neuroscience\| PubMed ID: 23542688	2013
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell reports\| PubMed ID: 23545496	2013
Conversion of mature human β-cells into glucagon-producing α-cells. Diabetes\| PubMed ID: 23569174	2013
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS biology\| PubMed ID: 23610556	2013
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. The EMBO journal\| PubMed ID: 23644381	2013
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. The American journal of pathology\| PubMed ID: 23665202	2013
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome biology\| PubMed ID: 23714178	2013
Lgr proteins in epithelial stem cell biology. Development (Cambridge, England)\| PubMed ID: 23715542	2013
A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nature medicine\| PubMed ID: 23727931	2013
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (New York, N.Y.)\| PubMed ID: 23744940	2013
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell reports\| PubMed ID: 23809763	2013
Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine. Regenerative medicine\| PubMed ID: 23826690	2013
Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors. Stem cells (Dayton, Ohio)\| PubMed ID: 23836510	2013
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nature communications\| PubMed ID: 23839311	2013
The intestinal crypt, a prototype stem cell compartment. Cell\| PubMed ID: 23870119	2013
LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23975934	2013
Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis\| PubMed ID: 23996931	2014
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The EMBO journal\| PubMed ID: 24045232	2013
A gutsy approach to stem cells and signalling: an interview with Hans Clevers. Disease models & mechanisms\| PubMed ID: 24046385	2013
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell\| PubMed ID: 24120136	2013
Generation of L cells in mouse and human small intestine organoids. Diabetes\| PubMed ID: 24130334	2014
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. PloS one\| PubMed ID: 24130821	2013
Generation of BAC transgenic epithelial organoids. PloS one\| PubMed ID: 24204693	2013
LGR5 positivity defines stem-like cells in colorectal cancer. Carcinogenesis\| PubMed ID: 24282287	2014
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nature methods\| PubMed ID: 24292484	2014
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. The Journal of clinical investigation\| PubMed ID: 24292712	2014
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell stem cell\| PubMed ID: 24315439	2013
Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium. Gastroenterology\| PubMed ID: 24333384	2014
Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling. PloS one\| PubMed ID: 24349440	2013
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. EMBO reports\| PubMed ID: 24355609	2014
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. The EMBO journal\| PubMed ID: 24413017	2014
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature\| PubMed ID: 24463518	2014
Ovarian LGR5 is critical for successful pregnancy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24469993	2014
Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem cells (Dayton, Ohio)\| PubMed ID: 24496776	2014
Retroviral gene expression control in primary organoid cultures. Current protocols in stem cell biology\| PubMed ID: 24510288	2013
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature\| PubMed ID: 24531760	2014
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes & development\| PubMed ID: 24532711	2014
STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural development\| PubMed ID: 24594058	2014
KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Cancer research\| PubMed ID: 24626089	2014
Organoid cultures for the analysis of cancer phenotypes. Current opinion in genetics & development\| PubMed ID: 24657539	2014
A promoter-level mammalian expression atlas. Nature\| PubMed ID: 24670764	2014
Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways. Cancer research\| PubMed ID: 24695361	2014
Loss of syntaxin 3 causes variant microvillus inclusion disease. Gastroenterology\| PubMed ID: 24726755	2014
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nature genetics\| PubMed ID: 24816253	2014
Stem Cells Marked by the R-Spondin Receptor LGR5. Gastroenterology\| PubMed ID: 24859206	2014
Polarizing intestinal epithelial cells electrically through Ror2. Journal of cell science\| PubMed ID: 24928904	2014
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem cell reports\| PubMed ID: 24936470	2014
Paneth cells. Current biology : CB\| PubMed ID: 24937274	2014
Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development. The Journal of biological chemistry\| PubMed ID: 24966324	2014
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ. The Journal of experimental medicine\| PubMed ID: 24980747	2014
Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature\| PubMed ID: 25043003	2014
Glial origin of mesenchymal stem cells in a tooth model system. Nature\| PubMed ID: 25079316	2014
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. The EMBO journal\| PubMed ID: 25092767	2014
Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency. The Journal of allergy and clinical immunology\| PubMed ID: 25174867	2014
Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell\| PubMed ID: 25201529	2014
Organoid cultures derived from patients with advanced prostate cancer. Cell\| PubMed ID: 25201530	2014
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell reports\| PubMed ID: 25242322	2014
Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus. Stem cell reports\| PubMed ID: 25254337	2014
A20 controls intestinal homeostasis through cell-specific activities. Nature communications\| PubMed ID: 25267258	2014
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science (New York, N.Y.)\| PubMed ID: 25278615	2014
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology\| PubMed ID: 25307862	2015
Plasticity within stem cell hierarchies in mammalian epithelia. Trends in cell biology\| PubMed ID: 25308311	2015
Large-scale identification of coregulated enhancer networks in the adult human brain. Cell reports\| PubMed ID: 25373911	2014
Targeting development of incretin-producing cells increases insulin secretion. The Journal of clinical investigation\| PubMed ID: 25500886	2015
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nature communications\| PubMed ID: 25500896	2014
Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell\| PubMed ID: 25533785	2015
Organoid models of human and mouse ductal pancreatic cancer. Cell\| PubMed ID: 25557080	2015
Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron\| PubMed ID: 25578362	2015
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell stem cell\| PubMed ID: 25620640	2015
Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25636467	2015
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. The Journal of pathology\| PubMed ID: 25712196	2015
Premigratory and migratory neural crest cells are multipotent in vivo. Cell stem cell\| PubMed ID: 25748934	2015
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science translational medicine\| PubMed ID: 25834110	2015
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells. Stem cell reports\| PubMed ID: 25892522	2015
Efficient intracellular delivery of native proteins. Cell\| PubMed ID: 25910214	2015
Sequential cancer mutations in cultured human intestinal stem cells. Nature\| PubMed ID: 25924068	2015
Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell\| PubMed ID: 25957691	2015
Q&A: Hans Clevers. Banking on organoids. Nature\| PubMed ID: 25970453	2015
Repairing organs: lessons from intestine and liver. Trends in genetics : TIG\| PubMed ID: 25989898	2015
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26023187	2015
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell\| PubMed ID: 26091037	2015
SnapShot: Growing Organoids from Stem Cells. Cell\| PubMed ID: 26091044	2015
Expanding intestinal stem cells in culture. Cell research\| PubMed ID: 26169607	2015
Development and application of human adult stem or progenitor cell organoids. Nature reviews. Nephrology\| PubMed ID: 26215513	2015
In Situ Hybridization to Identify Gut Stem Cells. Current protocols in stem cell biology\| PubMed ID: 26237569	2015
Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature\| PubMed ID: 26287467	2015
Lgr4 Controls Specialization of Female Gonads in Mice. Biology of reproduction\| PubMed ID: 26333992	2015
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26392529	2015
Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. The Journal of pathology\| PubMed ID: 26419819	2015
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem cell reports\| PubMed ID: 26455412	2015
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26460009	2015
Radical Sabbaticals. Cell\| PubMed ID: 26544929	2015
The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system. Gut microbes\| PubMed ID: 26558327	2015
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem cell reports\| PubMed ID: 26607954	2015
Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. Cell reports\| PubMed ID: 26628377	2015
STEM CELLS. What is an adult stem cell? Science (New York, N.Y.)\| PubMed ID: 26659043	2015
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem cell reports\| PubMed ID: 26724906	2016
Reparative inflammation takes charge of tissue regeneration. Nature\| PubMed ID: 26791721	2016
Organoid culture systems for prostate epithelial and cancer tissue. Nature protocols\| PubMed ID: 26797458	2016
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell stem cell\| PubMed ID: 26831517	2016
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature\| PubMed ID: 26863187	2016
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Scientific reports\| PubMed ID: 26915950	2016
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature communications\| PubMed ID: 26955760	2016
Tissue-specific designs of stem cell hierarchies. Nature cell biology\| PubMed ID: 26999737	2016
Modeling pancreatic cancer with organoids. Trends in cancer\| PubMed ID: 27135056	2016
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell stem cell\| PubMed ID: 27184401	2016
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO molecular medicine\| PubMed ID: 27221051	2016
CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27246017	2016
Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use. EMBO reports\| PubMed ID: 27296278	2016
Model organoids provide new research opportunities for ductal pancreatic cancer. Molecular & cellular oncology\| PubMed ID: 27308531	2016
Modeling Development and Disease with Organoids. Cell\| PubMed ID: 27315476	2016
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. Gut\| PubMed ID: 27329244	2016
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Science translational medicine\| PubMed ID: 27334259	2016
De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell stem cell\| PubMed ID: 27345837	2016
Analysis of neural crest-derived clones reveals novel aspects of facial development. Science advances\| PubMed ID: 27493992	2016
Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding. Molecular cell\| PubMed ID: 27494556	2016
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature communications\| PubMed ID: 27558455	2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nature protocols\| PubMed ID: 27560176	2016
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573849	2016
The Generation of Organoids for Studying Wnt Signaling. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27590160	2016
Organoids: Modeling Development and the Stem Cell Niche in a Dish. Developmental cell\| PubMed ID: 27676432	2016
Tissue-specific mutation accumulation in human adult stem cells during life. Nature\| PubMed ID: 27698416	2016
Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27708166	2016
Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature immunology\| PubMed ID: 27776108	2016
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration. Development (Cambridge, England)\| PubMed ID: 27802133	2016
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening. eLife\| PubMed ID: 27845624	2016
Designer matrices for intestinal stem cell and organoid culture. Nature\| PubMed ID: 27851739	2016
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature medicine\| PubMed ID: 27869803	2017
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells. Cell stem cell\| PubMed ID: 27939219	2017
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28028233	2017
IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2. The Journal of allergy and clinical immunology\| PubMed ID: 28040417	2016
Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell reports\| PubMed ID: 28052255	2017
Erratum: Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nature immunology\| PubMed ID: 28102212	2017
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