Hubrecht Institute for Developmental Biology and Stem Cell Research
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Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.
Cancer research Oct, 2010 | Pubmed ID: 20736363
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.
Cell Oct, 2010 | Pubmed ID: 20887898
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice.
Gastroenterology Jan, 2011 | Pubmed ID: 20951138
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.
Developmental cell Apr, 2009 | Pubmed ID: 19386264
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
Gastroenterology Jul, 2009 | Pubmed ID: 19450592
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
Nature neuroscience Jul, 2009 | Pubmed ID: 19503085
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gastroenterology Oct, 2009 | Pubmed ID: 19549527
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
Physiological reviews Jul, 2009 | Pubmed ID: 19584313
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast cancer research and treatment May, 2010 | Pubmed ID: 19593635
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.
Nature genetics Oct, 2009 | Pubmed ID: 19718028
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2009 | Pubmed ID: 19741146
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
The Journal of clinical investigation Oct, 2009 | Pubmed ID: 19759516
The kinase TNIK is an essential activator of Wnt target genes.
The EMBO journal Nov, 2009 | Pubmed ID: 19816403
Eyeing up new Wnt pathway players.
Cell Oct, 2009 | Pubmed ID: 19837026
Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19850932
Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish.
Zebrafish Dec, 2009 | Pubmed ID: 19929219
In situ hybridization to identify gut stem cells.
Current protocols in stem cell biology Jan, 2010 | Pubmed ID: 20049690
Searching for adult stem cells in the intestine.
EMBO molecular medicine Aug, 2009 | Pubmed ID: 20049728
Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.
Disease models & mechanisms Jan-Feb, 2010 | Pubmed ID: 20075383
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Cell stem cell Jan, 2010 | Pubmed ID: 20085740
Coexistence of quiescent and active adult stem cells in mammals.
Science (New York, N.Y.) Jan, 2010 | Pubmed ID: 20110496
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.
Biological chemistry Feb-Mar, 2010 | Pubmed ID: 20128690
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.
Cell stem cell Feb, 2010 | Pubmed ID: 20144789
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Science (New York, N.Y.) Mar, 2010 | Pubmed ID: 20223988
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Molecular cell Mar, 2010 | Pubmed ID: 20227366
Active Wnt signaling in response to cardiac injury.
Basic research in cardiology Sep, 2010 | Pubmed ID: 20373104
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.
Gastroenterology May, 2010 | Pubmed ID: 20417836
Lineage tracing in the intestinal epithelium.
Current protocols in stem cell biology May, 2010 | Pubmed ID: 20443207
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.
Gastroenterology Sep, 2010 | Pubmed ID: 20542037
Wnts as self-renewal factors: mammary stem cells and beyond.
Cell stem cell Jun, 2010 | Pubmed ID: 20569681
Stem cells and cancer of the stomach and intestine.
Molecular oncology Oct, 2010 | Pubmed ID: 20598659
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20696899
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Developmental cell Aug, 2010 | Pubmed ID: 20708588
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.
Nature communications , 2010 | Pubmed ID: 20975679
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
EMBO molecular medicine Nov, 2010 | Pubmed ID: 20976827
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice.
The Journal of clinical investigation Nov, 2010 | Pubmed ID: 20978345
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21041628
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
PLoS biology , 2010 | Pubmed ID: 21103407
Tissue-resident adult stem cell populations of rapidly self-renewing organs.
Cell stem cell Dec, 2010 | Pubmed ID: 21112561
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature Jan, 2011 | Pubmed ID: 21113151
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.
PloS one , 2010 | Pubmed ID: 21152096
Sox9 marks adult organ progenitors.
Nature genetics Jan, 2011 | Pubmed ID: 21217637
Tracking adult stem cells.
EMBO reports Feb, 2011 | Pubmed ID: 21252944
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.
PLoS computational biology , 2011 | Pubmed ID: 21253562
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.
The EMBO journal Mar, 2011 | Pubmed ID: 21297579
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21368212
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
The Journal of cell biology Mar, 2011 | Pubmed ID: 21383077
The cancer stem cell: premises, promises and challenges.
Nature medicine Mar, 2011 | Pubmed ID: 21386835
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.
Cell stem cell May, 2011 | Pubmed ID: 21419747
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.
Gastroenterology Jul, 2011 | Pubmed ID: 21459094
Strategies for homeostatic stem cell self-renewal in adult tissues.
Cell Jun, 2011 | Pubmed ID: 21663791
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Cancer cell Jun, 2011 | Pubmed ID: 21665151
Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.
Journal of proteome research Aug, 2011 | Pubmed ID: 21696214
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.
Gastroenterology Oct, 2011 | Pubmed ID: 21704588
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature Aug, 2011 | Pubmed ID: 21727895
Stem cell self-renewal in intestinal crypt.
Experimental cell research Nov, 2011 | Pubmed ID: 21787769
Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment.
Nature protocols Aug, 2011 | Pubmed ID: 21799490
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.
PloS one , 2011 | Pubmed ID: 21826198
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.
Gastroenterology Nov, 2011 | Pubmed ID: 21889923
Isolation and in vitro expansion of human colonic stem cells.
Nature medicine Oct, 2011 | Pubmed ID: 21892181
Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes.
Nucleic acids research Jan, 2012 | Pubmed ID: 21914722
Single-cell dissection of transcriptional heterogeneity in human colon tumors.
Nature biotechnology Dec, 2011 | Pubmed ID: 22081019
Single-molecule transcript counting of stem-cell markers in the mouse intestine.
Nature cell biology Jan, 2012 | Pubmed ID: 22119784
Controlled gene expression in primary Lgr5 organoid cultures.
Nature methods Jan, 2012 | Pubmed ID: 22138822
Cdx2 determines the fate of postnatal intestinal endoderm.
Development (Cambridge, England) Feb, 2012 | Pubmed ID: 22190642
Method for estimating the single molecular affinity.
Analytical biochemistry Feb, 2012 | Pubmed ID: 22209736
Neural stem cells for diabetes cell-based therapy.
EMBO molecular medicine Dec, 2011 | Pubmed ID: 22238783
Optimality in the development of intestinal crypts.
Cell Feb, 2012 | Pubmed ID: 22304925
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.
Nature cell biology Apr, 2012 | Pubmed ID: 22388892
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.
Molecular and cellular biology May, 2012 | Pubmed ID: 22393260
What does the concept of the stem cell niche really mean today?
BMC biology , 2012 | Pubmed ID: 22405133
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.
Nature medicine Apr, 2012 | Pubmed ID: 22406745
The R-spondin protein family.
Genome biology , 2012 | Pubmed ID: 22439850
Wnt signaling, stem cells, and cancer of the gastrointestinal tract.
Cold Spring Harbor perspectives in biology Apr, 2012 | Pubmed ID: 22474007
Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields.
Science signaling Apr, 2012 | Pubmed ID: 22494969
In vitro expansion and transplantation of intestinal crypt stem cells.
Gastroenterology Jul, 2012 | Pubmed ID: 22613623
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.
The EMBO journal Jun, 2012 | Pubmed ID: 22617424
On the biomechanics of stem cell niche formation in the gut--modelling growing organoids.
The FEBS journal Sep, 2012 | Pubmed ID: 22632461
Wnt/β-catenin signaling and disease.
Cell Jun, 2012 | Pubmed ID: 22682243
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
Cell Jun, 2012 | Pubmed ID: 22682247
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
The EMBO journal Jul, 2012 | Pubmed ID: 22692129
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
Molecular and cellular biology Sep, 2012 | Pubmed ID: 22778137
Rap2A links intestinal cell polarity to brush border formation.
Nature cell biology Aug, 2012 | Pubmed ID: 22797597
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Nature Jul, 2012 | Pubmed ID: 22837003
Crypt base columnar stem cells in small intestines of mice are radioresistant.
Gastroenterology Nov, 2012 | Pubmed ID: 22841781
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.
Science (New York, N.Y.) Aug, 2012 | Pubmed ID: 22855427
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2012 | Pubmed ID: 22893683
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Nature Aug, 2012 | Pubmed ID: 22895187
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
Gastroenterology Dec, 2012 | Pubmed ID: 22922422
Cell biology. The unusual case of Porcupine.
Science (New York, N.Y.) Aug, 2012 | Pubmed ID: 22923569
Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland.
The Journal of pathology Nov, 2012 | Pubmed ID: 22926799
Modulating WNT receptor turnover for tissue repair.
Nature biotechnology Sep, 2012 | Pubmed ID: 22965053
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells.
Stem cells (Dayton, Ohio) Nov, 2012 | Pubmed ID: 22969042
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Cell reports Sep, 2012 | Pubmed ID: 22999937
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
Nature cell biology Oct, 2012 | Pubmed ID: 23000963
Identifying the stem cell of the intestinal crypt: strategies and pitfalls.
Cell stem cell Oct, 2012 | Pubmed ID: 23040474
The Paneth cell, caloric restriction, and intestinal integrity.
The New England journal of medicine Oct, 2012 | Pubmed ID: 23075184
Primary mouse small intestinal epithelial cell cultures.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23097115
Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias.
Immunity Nov, 2012 | Pubmed ID: 23159221
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
PLoS biology , 2012 | Pubmed ID: 23185135
Identification of a clonally expanding haematopoietic compartment in bone marrow.
The EMBO journal Jan, 2013 | Pubmed ID: 23188081
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Cell Dec, 2012 | Pubmed ID: 23260145
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Cell Jan, 2013 | Pubmed ID: 23273993
Immunosurveillance against tetraploidization-induced colon tumorigenesis.
Cell cycle (Georgetown, Tex.) Feb, 2013 | Pubmed ID: 23324343
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature Feb, 2013 | Pubmed ID: 23354049
Intestinal regeneration: YAP-tumor suppressor and oncoprotein?
Current biology : CB Feb, 2013 | Pubmed ID: 23391384
Paneth cells: maestros of the small intestinal crypts.
Annual review of physiology , 2013 | Pubmed ID: 23398152
Stem Cells: A unifying theory for the crypt.
Nature Mar, 2013 | Pubmed ID: 23446347
SnapShot: the intestinal crypt.
Cell Feb, 2013 | Pubmed ID: 23452862
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.
Nature neuroscience May, 2013 | Pubmed ID: 23542688
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.
Cell reports Apr, 2013 | Pubmed ID: 23545496
Conversion of mature human β-cells into glucagon-producing α-cells.
Diabetes Jul, 2013 | Pubmed ID: 23569174
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.
PLoS biology , 2013 | Pubmed ID: 23610556
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls.
The EMBO journal May, 2013 | Pubmed ID: 23644381
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.
The American journal of pathology Jul, 2013 | Pubmed ID: 23665202
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.
Genome biology , 2013 | Pubmed ID: 23714178
Lgr proteins in epithelial stem cell biology.
Development (Cambridge, England) Jun, 2013 | Pubmed ID: 23715542
A functional CFTR assay using primary cystic fibrosis intestinal organoids.
Nature medicine Jul, 2013 | Pubmed ID: 23727931
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications.
Science (New York, N.Y.) Jun, 2013 | Pubmed ID: 23744940
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.
Cell reports Jun, 2013 | Pubmed ID: 23809763
Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine.
Regenerative medicine Jul, 2013 | Pubmed ID: 23826690
Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors.
Stem cells (Dayton, Ohio) Nov, 2013 | Pubmed ID: 23836510
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.
Nature communications , 2013 | Pubmed ID: 23839311
The intestinal crypt, a prototype stem cell compartment.
Cell Jul, 2013 | Pubmed ID: 23870119
LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2013 | Pubmed ID: 23975934
Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.
Carcinogenesis Jan, 2014 | Pubmed ID: 23996931
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
The EMBO journal Oct, 2013 | Pubmed ID: 24045232
A gutsy approach to stem cells and signalling: an interview with Hans Clevers.
Disease models & mechanisms Sep, 2013 | Pubmed ID: 24046385
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.
Cell Oct, 2013 | Pubmed ID: 24120136
Generation of L cells in mouse and human small intestine organoids.
Diabetes Feb, 2014 | Pubmed ID: 24130334
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.
PloS one , 2013 | Pubmed ID: 24130821
Generation of BAC transgenic epithelial organoids.
PloS one , 2013 | Pubmed ID: 24204693
LGR5 positivity defines stem-like cells in colorectal cancer.
Carcinogenesis Apr, 2014 | Pubmed ID: 24282287
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.
Nature methods Jan, 2014 | Pubmed ID: 24292484
TTC7A mutations disrupt intestinal epithelial apicobasal polarity.
The Journal of clinical investigation Jan, 2014 | Pubmed ID: 24292712
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.
Cell stem cell Dec, 2013 | Pubmed ID: 24315439
Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium.
Gastroenterology Apr, 2014 | Pubmed ID: 24333384
Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
PloS one , 2013 | Pubmed ID: 24349440
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
EMBO reports Jan, 2014 | Pubmed ID: 24355609
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.
The EMBO journal Jan, 2014 | Pubmed ID: 24413017
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.
Nature Mar, 2014 | Pubmed ID: 24463518
Ovarian LGR5 is critical for successful pregnancy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2014 | Pubmed ID: 24469993
Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.
Stem cells (Dayton, Ohio) May, 2014 | Pubmed ID: 24496776
Retroviral gene expression control in primary organoid cultures.
Current protocols in stem cell biology , 2013 | Pubmed ID: 24510288
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.
Nature Mar, 2014 | Pubmed ID: 24531760
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
Genes & development Feb, 2014 | Pubmed ID: 24532711
STRAD pseudokinases regulate axogenesis and LKB1 stability.
Neural development , 2014 | Pubmed ID: 24594058
KLF5 regulates the integrity and oncogenicity of intestinal stem cells.
Cancer research May, 2014 | Pubmed ID: 24626089
Organoid cultures for the analysis of cancer phenotypes.
Current opinion in genetics & development Feb, 2014 | Pubmed ID: 24657539
A promoter-level mammalian expression atlas.
Nature Mar, 2014 | Pubmed ID: 24670764
Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.
Cancer research Jun, 2014 | Pubmed ID: 24695361
Loss of syntaxin 3 causes variant microvillus inclusion disease.
Gastroenterology Jul, 2014 | Pubmed ID: 24726755
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Nature genetics Jun, 2014 | Pubmed ID: 24816253
Stem Cells Marked by the R-Spondin Receptor LGR5.
Gastroenterology Aug, 2014 | Pubmed ID: 24859206
Polarizing intestinal epithelial cells electrically through Ror2.
Journal of cell science Aug, 2014 | Pubmed ID: 24928904
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.
Stem cell reports Jun, 2014 | Pubmed ID: 24936470
Paneth cells.
Current biology : CB Jun, 2014 | Pubmed ID: 24937274
Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 24966324
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.
The Journal of experimental medicine Jun, 2014 | Pubmed ID: 24980747
Genome sequencing of normal cells reveals developmental lineages and mutational processes.
Nature Sep, 2014 | Pubmed ID: 25043003
Glial origin of mesenchymal stem cells in a tooth model system.
Nature Sep, 2014 | Pubmed ID: 25079316
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.
The EMBO journal Sep, 2014 | Pubmed ID: 25092767
Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency.
The Journal of allergy and clinical immunology Dec, 2014 | Pubmed ID: 25174867
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Cell Sep, 2014 | Pubmed ID: 25201529
Organoid cultures derived from patients with advanced prostate cancer.
Cell Sep, 2014 | Pubmed ID: 25201530
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.
Cell reports Sep, 2014 | Pubmed ID: 25242322
Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.
Stem cell reports Aug, 2014 | Pubmed ID: 25254337
A20 controls intestinal homeostasis through cell-specific activities.
Nature communications , 2014 | Pubmed ID: 25267258
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.
Science (New York, N.Y.) Oct, 2014 | Pubmed ID: 25278615
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Gastroenterology Jan, 2015 | Pubmed ID: 25307862
Plasticity within stem cell hierarchies in mammalian epithelia.
Trends in cell biology Feb, 2015 | Pubmed ID: 25308311
Large-scale identification of coregulated enhancer networks in the adult human brain.
Cell reports Oct, 2014 | Pubmed ID: 25373911
Targeting development of incretin-producing cells increases insulin secretion.
The Journal of clinical investigation Jan, 2015 | Pubmed ID: 25500886
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.
Nature communications , 2014 | Pubmed ID: 25500896
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Cell Jan, 2015 | Pubmed ID: 25533785
Organoid models of human and mouse ductal pancreatic cancer.
Cell Jan, 2015 | Pubmed ID: 25557080
Microbiota controls the homeostasis of glial cells in the gut lamina propria.
Neuron Jan, 2015 | Pubmed ID: 25578362
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.
Cell stem cell Feb, 2015 | Pubmed ID: 25620640
Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25636467
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.
The Journal of pathology Jun, 2015 | Pubmed ID: 25712196
Premigratory and migratory neural crest cells are multipotent in vivo.
Cell stem cell Mar, 2015 | Pubmed ID: 25748934
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.
Science translational medicine Apr, 2015 | Pubmed ID: 25834110
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.
Stem cell reports May, 2015 | Pubmed ID: 25892522
Efficient intracellular delivery of native proteins.
Cell Apr, 2015 | Pubmed ID: 25910214
Sequential cancer mutations in cultured human intestinal stem cells.
Nature May, 2015 | Pubmed ID: 25924068
Prospective derivation of a living organoid biobank of colorectal cancer patients.
Cell May, 2015 | Pubmed ID: 25957691
Q&A: Hans Clevers. Banking on organoids.
Nature May, 2015 | Pubmed ID: 25970453
Repairing organs: lessons from intestine and liver.
Trends in genetics : TIG Jun, 2015 | Pubmed ID: 25989898
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2015 | Pubmed ID: 26023187
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Cell Jun, 2015 | Pubmed ID: 26091037
SnapShot: Growing Organoids from Stem Cells.
Cell Jun, 2015 | Pubmed ID: 26091044
Expanding intestinal stem cells in culture.
Cell research Sep, 2015 | Pubmed ID: 26169607
Development and application of human adult stem or progenitor cell organoids.
Nature reviews. Nephrology Sep, 2015 | Pubmed ID: 26215513
In Situ Hybridization to Identify Gut Stem Cells.
Current protocols in stem cell biology , 2015 | Pubmed ID: 26237569
Single-cell messenger RNA sequencing reveals rare intestinal cell types.
Nature Sep, 2015 | Pubmed ID: 26287467
Lgr4 Controls Specialization of Female Gonads in Mice.
Biology of reproduction Oct, 2015 | Pubmed ID: 26333992
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2015 | Pubmed ID: 26392529
Pre-clinical Models of Pancreatic Ductal Adenocarcinoma.
The Journal of pathology Sep, 2015 | Pubmed ID: 26419819
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
Stem cell reports Oct, 2015 | Pubmed ID: 26455412
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2015 | Pubmed ID: 26460009
Radical Sabbaticals.
Cell Nov, 2015 | Pubmed ID: 26544929
The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system.
Gut microbes , 2015 | Pubmed ID: 26558327
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Stem cell reports Nov, 2015 | Pubmed ID: 26607954
Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.
Cell reports Dec, 2015 | Pubmed ID: 26628377
STEM CELLS. What is an adult stem cell?
Science (New York, N.Y.) Dec, 2015 | Pubmed ID: 26659043
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals.
Stem cell reports Jan, 2016 | Pubmed ID: 26724906
Reparative inflammation takes charge of tissue regeneration.
Nature Jan, 2016 | Pubmed ID: 26791721
Organoid culture systems for prostate epithelial and cancer tissue.
Nature protocols Feb, 2016 | Pubmed ID: 26797458
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.
Cell stem cell Feb, 2016 | Pubmed ID: 26831517
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.
Nature Feb, 2016 | Pubmed ID: 26863187
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.
Scientific reports Feb, 2016 | Pubmed ID: 26915950
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.
Nature communications Mar, 2016 | Pubmed ID: 26955760
Tissue-specific designs of stem cell hierarchies.
Nature cell biology Apr, 2016 | Pubmed ID: 26999737
Modeling pancreatic cancer with organoids.
Trends in cancer Apr, 2016 | Pubmed ID: 27135056
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
Cell stem cell Aug, 2016 | Pubmed ID: 27184401
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.
EMBO molecular medicine Jul, 2016 | Pubmed ID: 27221051
CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27246017
Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use.
EMBO reports Jul, 2016 | Pubmed ID: 27296278
Model organoids provide new research opportunities for ductal pancreatic cancer.
Molecular & cellular oncology Jan, 2016 | Pubmed ID: 27308531
Modeling Development and Disease with Organoids.
Cell Jun, 2016 | Pubmed ID: 27315476
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation.
Gut Jun, 2016 | Pubmed ID: 27329244
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis.
Science translational medicine Jun, 2016 | Pubmed ID: 27334259
De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data.
Cell stem cell Aug, 2016 | Pubmed ID: 27345837
Analysis of neural crest-derived clones reveals novel aspects of facial development.
Science advances Aug, 2016 | Pubmed ID: 27493992
Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding.
Molecular cell Aug, 2016 | Pubmed ID: 27494556
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.
Nature communications Aug, 2016 | Pubmed ID: 27558455
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols Sep, 2016 | Pubmed ID: 27560176
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2016 | Pubmed ID: 27573849
The Generation of Organoids for Studying Wnt Signaling.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27590160
Organoids: Modeling Development and the Stem Cell Niche in a Dish.
Developmental cell Sep, 2016 | Pubmed ID: 27676432
Tissue-specific mutation accumulation in human adult stem cells during life.
Nature Oct, 2016 | Pubmed ID: 27698416
Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2016 | Pubmed ID: 27708166
Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells.
Nature immunology Dec, 2016 | Pubmed ID: 27776108
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.
Development (Cambridge, England) Oct, 2016 | Pubmed ID: 27802133
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.
eLife Nov, 2016 | Pubmed ID: 27845624
Designer matrices for intestinal stem cell and organoid culture.
Nature Nov, 2016 | Pubmed ID: 27851739
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Nature medicine Jan, 2017 | Pubmed ID: 27869803
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.
Cell stem cell Feb, 2017 | Pubmed ID: 27939219
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2017 | Pubmed ID: 28028233
IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2.
The Journal of allergy and clinical immunology Dec, 2016 | Pubmed ID: 28040417
Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.
Cell reports Jan, 2017 | Pubmed ID: 28052255
Erratum: Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells.
Nature immunology Jan, 2017 | Pubmed ID: 28102212
Human tissues in a dish: The research and ethical implications of organoid technology.
Science (New York, N.Y.) Jan, 2017 | Pubmed ID: 28104841
Interrogating open issues in cancer precision medicine with patient-derived xenografts.
Nature reviews. Cancer 01, 2017 | Pubmed ID: 28104906
CRISPR/Cas 9 genome editing and its applications in organoids.
American journal of physiology. Gastrointestinal and liver physiology Jan, 2017 | Pubmed ID: 28126704
WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.
British journal of pharmacology Dec, 2017 | Pubmed ID: 28244067
Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels.
Development (Cambridge, England) 03, 2017 | Pubmed ID: 28292848
SARS-CoV-2 productively infects human gut enterocytes.
Science (New York, N.Y.) 07, 2020 | Pubmed ID: 32358202
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.
Cell 06, 2020 | Pubmed ID: 32407674
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.
Nature communications 05, 2020 | Pubmed ID: 32461556
COVID-19: organoids go viral.
Nature reviews. Molecular cell biology 07, 2020 | Pubmed ID: 32483314
Primary Intestinal Epithelial Organoid Culture.
Methods in molecular biology (Clifton, N.J.) , 2020 | Pubmed ID: 32705642
Mathematical model of colorectal cancer initiation.
Proceedings of the National Academy of Sciences of the United States of America 08, 2020 | Pubmed ID: 32788368
Human-Derived Model Systems in Gynecological Cancer Research.
Trends in cancer 12, 2020 | Pubmed ID: 32855097
Establishment of patient-derived cancer organoids for drug-screening applications.
Nature protocols 10, 2020 | Pubmed ID: 32929210
Cell fate specification and differentiation in the adult mammalian intestine.
Nature reviews. Molecular cell biology 01, 2021 | Pubmed ID: 32958874
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids.
Cell stem cell Nov, 2020 | Pubmed ID: 33157047
Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver.
Nature protocols 01, 2021 | Pubmed ID: 33247284
Author Correction: Establishment of patient-derived cancer organoids for drug-screening applications.
Nature protocols Jan, 2021 | Pubmed ID: 33437066
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2021 | Pubmed ID: 33500353
Derivation of snake venom gland organoids for in vitro venom production.
Nature protocols 03, 2021 | Pubmed ID: 33504990
Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids.
Developmental biology Jun, 2021 | Pubmed ID: 33571486
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.
Nature protocols 04, 2021 | Pubmed ID: 33674788
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.
Cell reports Mar, 2021 | Pubmed ID: 33691112
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19.
Stem cell reports 03, 2021 | Pubmed ID: 33691146
Exploring the human lacrimal gland using organoids and single-cell sequencing.
Cell stem cell Mar, 2021 | Pubmed ID: 33730555
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.
Cell stem cell Apr, 2021 | Pubmed ID: 33852917
All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
Nucleic acids research Apr, 2001 | Pubmed ID: 11266540
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.
The EMBO journal Sep, 2001 | Pubmed ID: 11532957
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
EMBO reports Jan, 2002 | Pubmed ID: 11751573
Wnt signaling controls the phosphorylation status of beta-catenin.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11834740
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
Genes & development May, 2002 | Pubmed ID: 12023307
Identification of two novel regulated serines in the N terminus of beta-catenin.
Experimental cell research Jun, 2002 | Pubmed ID: 12027456
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International immunology Nov, 2003 | Pubmed ID: 14565933
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Transcription factor target practice.
Cell Jan, 2006 | Pubmed ID: 16413477
The intestinal stem cell.
Genes & development Jul, 2008 | Pubmed ID: 18628392
Stem cells, self-renewal, and differentiation in the intestinal epithelium.
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Identification of primary MAFB target genes in multiple myeloma.
Experimental hematology Jan, 2009 | Pubmed ID: 19013005
Wnt signaling, lgr5, and stem cells in the intestine and skin.
The American journal of pathology Mar, 2009 | Pubmed ID: 19197002
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell Mar, 2009 | Pubmed ID: 19269367
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Gastroenterology Jun, 2009 | Pubmed ID: 19324043
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature May, 2009 | Pubmed ID: 19329995
Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?
Biofabrication Mar, 2017 | Pubmed ID: 28211365
Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.
Nature communications Mar, 2017 | Pubmed ID: 28262686
Disease Modeling in Stem Cell-Derived 3D Organoid Systems.
Trends in molecular medicine May, 2017 | Pubmed ID: 28341301
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.
Nature May, 2017 | Pubmed ID: 28467818
SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells.
Stem cell reports Jun, 2017 | Pubmed ID: 28506535
Oncogene-inducible organoids as a miniature platform to assess cancer characteristics.
The Journal of cell biology Jun, 2017 | Pubmed ID: 28512141
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Cell Jun, 2017 | Pubmed ID: 28575679
MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.
Gastroenterology Oct, 2017 | Pubmed ID: 28716720
Cancer stem cells revisited.
Nature medicine Oct, 2017 | Pubmed ID: 28985214
The Human Cell Atlas.
eLife 12, 2017 | Pubmed ID: 29206104
Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.
Blood Mar, 2018 | Pubmed ID: 29212806
Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.
Nature protocols Jan, 2018 | Pubmed ID: 29215633
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell Jan, 2018 | Pubmed ID: 29224780
Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2017 | Pubmed ID: 29237753
A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche.
Cell reports Dec, 2017 | Pubmed ID: 29241552
Imaging organoids: a bright future ahead.
Nature methods Jan, 2018 | Pubmed ID: 29298292
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2018 | Pubmed ID: 29311336
Defining Adult Stem Cells by Function, not by Phenotype.
Annual review of biochemistry Jun, 2018 | Pubmed ID: 29494240
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.
Stem cell reports Mar, 2018 | Pubmed ID: 29539434
Intra-tumour diversification in colorectal cancer at the single-cell level.
Nature Apr, 2018 | Pubmed ID: 29643510
Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.
Emerging microbes & infections May, 2018 | Pubmed ID: 29743570
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications May, 2018 | Pubmed ID: 29765026
Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche.
Science (New York, N.Y.) Jun, 2018 | Pubmed ID: 29773667
Use and application of 3D-organoid technology.
Human molecular genetics Aug, 2018 | Pubmed ID: 29796608
Bioengineered bile ducts recapitulate key cholangiocyte functions.
Biofabrication Jun, 2018 | Pubmed ID: 29848792
Modelling Cryptosporidium infection in human small intestinal and lung organoids.
Nature microbiology 07, 2018 | Pubmed ID: 29946163
Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures.
The Lancet. Respiratory medicine Nov, 2018 | Pubmed ID: 30001996
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.
Nature cell biology Aug, 2018 | Pubmed ID: 30038251
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.
Cell Sep, 2018 | Pubmed ID: 30100188
Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling.
Cell reports Aug, 2018 | Pubmed ID: 30157426
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
Gastroenterology 01, 2019 | Pubmed ID: 30267714
Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids.
Gastroenterology Feb, 2019 | Pubmed ID: 30476497
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.
Cell 11, 2018 | Pubmed ID: 30500538
Profiling proliferative cells and their progeny in damaged murine hearts.
Proceedings of the National Academy of Sciences of the United States of America 12, 2018 | Pubmed ID: 30530645
Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis.
Cell reports Feb, 2019 | Pubmed ID: 30759382
Mouse and human urothelial cancer organoids: A tool for bladder cancer research.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2019 | Pubmed ID: 30787188
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Nature biotechnology 03, 2019 | Pubmed ID: 30833775
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
Nature medicine May, 2019 | Pubmed ID: 31011202
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Cancer discovery 07, 2019 | Pubmed ID: 31053628
High-resolution 3D imaging of fixed and cleared organoids.
Nature protocols 06, 2019 | Pubmed ID: 31053799
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.
Cell stem cell Jun, 2019 | Pubmed ID: 31130514
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2019 | Pubmed ID: 31253707
T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.
Immunity Jul, 2019 | Pubmed ID: 31278057
Xenograft and organoid model systems in cancer research.
The EMBO journal 08, 2019 | Pubmed ID: 31282586
A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues.
Advanced healthcare materials Oct, 2019 | Pubmed ID: 31402634
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.
Cell stem cell Sep, 2019 | Pubmed ID: 31422913
Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids.
Journal of the National Cancer Institute , | Pubmed ID: 31589320
Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy.
Journal of clinical medicine Nov, 2019 | Pubmed ID: 31694307
Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells.
Hepatology (Baltimore, Md.) Jul, 2020 | Pubmed ID: 31715015
Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.
Cell stem cell Jan, 2020 | Pubmed ID: 31761724
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2019 | Pubmed ID: 31818951
Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.
Inflammatory bowel diseases 05, 2020 | Pubmed ID: 31833544
Organoids: Avatars for Personalized Medicine.
The Keio journal of medicine , 2019 | Pubmed ID: 31875622
LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.
Gastroenterology Apr, 2020 | Pubmed ID: 31930988
Snake Venom Gland Organoids.
Cell Jan, 2020 | Pubmed ID: 31978343
Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a -Deficient Dog Model of Metabolic Liver Disease.
Cells Feb, 2020 | Pubmed ID: 32053895
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.
Cell stem cell Apr, 2020 | Pubmed ID: 32084388
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
The Journal of biological chemistry Apr, 2020 | Pubmed ID: 32086379
Mutational signature in colorectal cancer caused by genotoxic pks E. coli.
Nature Apr, 2020 | Pubmed ID: 32106218
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing.
Nature cell biology Mar, 2020 | Pubmed ID: 32123335
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies.
Science (New York, N.Y.) Mar, 2020 | Pubmed ID: 32139547
The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies.
Open biology Apr, 2020 | Pubmed ID: 32259456
Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine.
Cell reports May, 2020 | Pubmed ID: 32375033
Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses.
EBioMedicine Jun, 2020 | Pubmed ID: 32460166
Kidney Organoids and Tubuloids.
Cells May, 2020 | Pubmed ID: 32466429
Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses.
Cell reports Jun, 2020 | Pubmed ID: 32553164
Fasting-mimicking diet and hormone therapy induce breast cancer regression.
Nature Jul, 2020 | Pubmed ID: 32669709
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
Cell stem cell Nov, 2020 | Pubmed ID: 32818433
Intestinal Regeneration: Regulation by the Microenvironment.
Developmental cell 08, 2020 | Pubmed ID: 32841594
LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature 11, 2020 | Pubmed ID: 32894860
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.
Scientific reports Sep, 2020 | Pubmed ID: 32908163
A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing.
Cancers Sep, 2020 | Pubmed ID: 32962010
Single-cell derived tumor organoids display diversity in HLA class I peptide presentation.
Nature communications Oct, 2020 | Pubmed ID: 33087703
Translation and Replication Dynamics of Single RNA Viruses.
Cell Dec, 2020 | Pubmed ID: 33188777
Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.
Nature Dec, 2020 | Pubmed ID: 33273708
An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.
The EMBO journal Mar, 2021 | Pubmed ID: 33283287
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.
Scientific reports Dec, 2020 | Pubmed ID: 33318612
SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival.
Cancer letters Mar, 2021 | Pubmed ID: 33359449
The Organoid Cell Atlas.
Nature biotechnology Jan, 2021 | Pubmed ID: 33384458
Tissue regeneration: Reserve or reverse?
Science (New York, N.Y.) Feb, 2021 | Pubmed ID: 33602845
National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration.
American journal of respiratory cell and molecular biology Jul, 2021 | Pubmed ID: 33625958
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature Apr, 2021 | Pubmed ID: 33731935
Organoids and organs-on-chips: Insights into human gut-microbe interactions.
Cell host & microbe Jun, 2021 | Pubmed ID: 34111395
Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis.
EMBO molecular medicine Jul, 2021 | Pubmed ID: 34165243
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.
Genome biology Jul, 2021 | Pubmed ID: 34229738
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
Stem cell reports Sep, 2021 | Pubmed ID: 34358453
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids.
Life science alliance Oct, 2021 | Pubmed ID: 34373320
Evidence generation and reproducibility in cell and gene therapy research: A call to action.
Molecular therapy. Methods & clinical development Sep, 2021 | Pubmed ID: 34377737
Disease modeling following organoid-based expansion of airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology Oct, 2021 | Pubmed ID: 34378410
Intestinal organoid cocultures with microbes.
Nature protocols Oct, 2021 | Pubmed ID: 34381208
Single-cell Ribo-seq reveals cell cycle-dependent translational pausing.
Nature Sep, 2021 | Pubmed ID: 34497418
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses.
Nature communications Sep, 2021 | Pubmed ID: 34535662
Mycobacteria-host interactions in human bronchiolar airway organoids.
Molecular microbiology Mar, 2022 | Pubmed ID: 34605588
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.
PLoS genetics Nov, 2021 | Pubmed ID: 34752469
Molecular characterization of Barrett's esophagus at single-cell resolution.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2021 | Pubmed ID: 34795059
Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2021 | Pubmed ID: 34916298
Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis.
Cancer discovery Apr, 2022 | Pubmed ID: 34930787
Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
Gastroenterology Apr, 2022 | Pubmed ID: 34973294
RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
Stem cell reports Feb, 2022 | Pubmed ID: 34995498
BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states.
Cell reports Mar, 2022 | Pubmed ID: 35235783
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.
Nature cancer Apr, 2022 | Pubmed ID: 35469014
Patient-derived micro-organospheres enable clinical precision oncology.
Cell stem cell Jun, 2022 | Pubmed ID: 35508177
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant.
Cell discovery Jun, 2022 | Pubmed ID: 35710786
Uncovering the mode of action of engineered T cells in patient cancer organoids.
Nature biotechnology Jan, 2023 | Pubmed ID: 35879361
Rapid tissue prototyping with micro-organospheres.
Stem cell reports Sep, 2022 | Pubmed ID: 35985334
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
Cell stem cell Sep, 2022 | Pubmed ID: 36002022
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.
STAR protocols Sep, 2022 | Pubmed ID: 36042877
Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Nov, 2022 | Pubmed ID: 36058001
Patient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.
International journal of cancer Feb, 2023 | Pubmed ID: 36161653
Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS glycolytic colorectal tumors.
Communications biology Oct, 2022 | Pubmed ID: 36316440
Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation.
The Journal of clinical investigation Dec, 2022 | Pubmed ID: 36538378
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2023 | Pubmed ID: 36724260
Sylvia F. Boj1,
Annelotte M. Vonk2,
Marvin Statia1,
Jinyi Su1,
Johanna F. Dekkers3,
Robert R. G. Vries1,
Jeffrey M. Beekman2,
Hans Clevers1,4
1, Foundation Hubrecht Organoid Technology,
2Department of Pediatric Pulmonology, Regenerative Medicine Centre Utrecht, Wilhelmina Children's Hospital, University Medical Centre Utrecht,
3Department of Stem Cells and Cancer, Walter and Eliza Hall Institute of Medical Research,
4Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht
Marrit Putker*,1,
Rosemary Millen*,2,
René Overmeer*,3,
Else Driehuis2,4,
Maurice M. J. M. Zandvliet5,
Hans Clevers2,
Sylvia F. Boj3,
Qi-Xiang Li6
1, Crown Bioscience Netherlands B.V.,
2Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht,
3, Hubrecht Organoid Technology (HUB),
4Pathology dept, University Medical Center Utrecht,
5Department of Clinical Sciences - Companion Animals, Faculty of Veterinary Medicine, Utrecht University,
6, Crown Bioscience Inc.
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