Laboratory of Molecular Immunoregulation,
Cancer and Inflammation Program,
Center for Cancer Research,
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research
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Administration of either anti-CD40 or interleukin-12 following lethal total body irradiation induces acute lethal toxicity affecting the gut.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2002 | Pubmed ID: 12108917
Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2002 | Pubmed ID: 12370382
IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2004 | Pubmed ID: 15585838
Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma.
Journal of the National Cancer Institute Feb, 2006 | Pubmed ID: 16449679
Multicolor fluorescence-based approaches for imaging cytokine-induced alterations in the neovascularization, growth, metastasis, and apoptosis of murine neuroblastoma tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997) Mar-Apr, 2006 | Pubmed ID: 16531816
Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.
Journal of immunology (Baltimore, Md. : 1950) May, 2006 | Pubmed ID: 16670342
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Blood Oct, 2008 | Pubmed ID: 18664628
Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2009 | Pubmed ID: 19299733
Visualization and identification of IL-7 producing cells in reporter mice.
PloS one Nov, 2009 | Pubmed ID: 19907640
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.
Molecular and cellular biology Feb, 2010 | Pubmed ID: 19933849
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Nature genetics Sep, 2011 | Pubmed ID: 21892159
High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.
Cancer investigation Jun, 2012 | Pubmed ID: 22571338
HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.
AIDS (London, England) Jul, 2013 | Pubmed ID: 23965471
Oral Delivery of IL27 Recombinant Bacteria Attenuates Immune Colitis in Mice.
Gastroenterology Oct, 2013 | Pubmed ID: 24120477
Adaptive immunity to murine skin commensals.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 25002505
IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.
Frontiers in immunology , 2015 | Pubmed ID: 26834739
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.
PloS one , 2016 | Pubmed ID: 27171183
Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.
Leukemia Aug, 2018 | Pubmed ID: 29535426
IL-7-induced phosphorylation of the adaptor Crk-like and other targets.
Cellular signalling Jul, 2018 | Pubmed ID: 29581031
Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations.
Oncotarget Apr, 2018 | Pubmed ID: 29854301
New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia Jan, 2020 | Pubmed ID: 31439943
Mutations that collaborate with IL-7Ra signaling pathways to drive ALL.
Advances in biological regulation May, 2021 | Pubmed ID: 33578108
IL-7: Comprehensive review.
Cytokine Dec, 2022 | Pubmed ID: 36201890
A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.
International journal of molecular sciences Jan, 2023 | Pubmed ID: 36675167
IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium.
Frontiers in immunology , 2023 | Pubmed ID: 37153622
Gisele O. L. Rodrigues1,
WenQing Li1,
Sarah D. Cramer1,2,3,
Hila Y. Winer1,
Tu Chun Hsu1,2,3,
Timothy Gower4,
Julie A. Hixon1,
Scott K. Durum1
1Cytokines and Immunity Section, Cancer Innovation Laboratory, National Cancer Institute, National Institutes of Health,
2Comparative Biomedical Scientist Training Program, NIH,
3Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, Michigan State University,
4, NCI-Frederick Laboratory Animal Sciences Program
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