Laboratory of Molecular Immunoregulation,
Cancer and Inflammation Program,
Center for Cancer Research,
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research
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IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases.
Cellular signalling Sep, 2002 | Pubmed ID: 12034357
Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax.
Blood Jul, 2002 | Pubmed ID: 12070030
The role of cytokines in lymphocyte homeostasis.
BioTechniques Oct, 2002 | Pubmed ID: 12395926
Lymphocide: cytokines and the control of lymphoid homeostasis.
Nature reviews. Immunology Nov, 2002 | Pubmed ID: 12415306
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Immunity Nov, 2002 | Pubmed ID: 12433363
Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse.
Journal of immunological methods Mar, 2003 | Pubmed ID: 12609543
Interleukin-7 induces MUC1.
Cancer biology & therapy Mar-Apr, 2003 | Pubmed ID: 12750562
Death and Baxes: mechanisms of lymphotrophic cytokines.
Immunological reviews Jun, 2003 | Pubmed ID: 12752670
Bcl11: sibling rivalry in lymphoid development.
Nature immunology Jun, 2003 | Pubmed ID: 12774073
IL-7 induces tyrosine phosphorylation of clathrin heavy chain.
Cellular signalling Feb, 2004 | Pubmed ID: 14636898
Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15123689
Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
Molecular and cellular biology Jul, 2004 | Pubmed ID: 15226449
Cytokine-driven cell cycling is mediated through Cdc25A.
The Journal of cell biology Jun, 2005 | Pubmed ID: 15928203
Cell biology of IL-7, a key lymphotrophin.
Cytokine & growth factor reviews Aug-Oct, 2005 | Pubmed ID: 15996891
The adaptive immune response in neonatal cerebral white matter damage.
Annals of neurology Dec, 2005 | Pubmed ID: 16250014
Stat5a/b are essential for normal lymphoid development and differentiation.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2006 | Pubmed ID: 16418296
IL-7 promotes T cell proliferation through destabilization of p27Kip1.
The Journal of experimental medicine Mar, 2006 | Pubmed ID: 16492801
Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations.
Journal of leukocyte biology Sep, 2006 | Pubmed ID: 16793919
Role of the intracellular domain of IL-7 receptor in T cell development.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17182559
IL-7 induces myelopoiesis and erythropoiesis.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2007 | Pubmed ID: 17237404
Interleukin-7 receptor expression: intelligent design.
Nature reviews. Immunology Feb, 2007 | Pubmed ID: 17259970
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.
Journal of leukocyte biology Oct, 2008 | Pubmed ID: 18653463
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Blood Oct, 2008 | Pubmed ID: 18664628
Live from the liver: hepatocyte IL-7.
Immunity Mar, 2009 | Pubmed ID: 19303385
Visualization and identification of IL-7 producing cells in reporter mice.
PloS one Nov, 2009 | Pubmed ID: 19907640
Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease.
Neurochemical research Jun, 2010 | Pubmed ID: 19915978
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.
Molecular and cellular biology Feb, 2010 | Pubmed ID: 19933849
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.
Experimental hematology Dec, 2010 | Pubmed ID: 20831893
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Nature genetics Sep, 2011 | Pubmed ID: 21892159
Detection of nuclear and membrane antigens by liquid-based cytology following long-term storage of d1 cells, karpas cells, and peripheral blood mononuclear cells.
Annals of clinical and laboratory science , 2011 | Pubmed ID: 22166505
Th17 cells are long lived and retain a stem cell-like molecular signature.
Immunity Dec, 2011 | Pubmed ID: 22177921
The human IL-7 receptor gene: deletions, polymorphisms and mutations.
Seminars in immunology Jun, 2012 | Pubmed ID: 22425228
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
Biochimica et biophysica acta Oct, 2012 | Pubmed ID: 22728771
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology Aug, 2012 | Pubmed ID: 22897934
Oral Delivery of IL27 Recombinant Bacteria Attenuates Immune Colitis in Mice.
Gastroenterology Oct, 2013 | Pubmed ID: 24120477
Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines.
Cytokine & growth factor reviews Dec, 2013 | Pubmed ID: 24231048
Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy?
Inflammatory bowel diseases Feb, 2014 | Pubmed ID: 24356385
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
PLoS pathogens Mar, 2014 | Pubmed ID: 24603698
IL-7 and TSLP receptors: twisted sisters.
Blood Jul, 2014 | Pubmed ID: 24993875
Adaptive immunity to murine skin commensals.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 25002505
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.
Nature immunology Mar, 2015 | Pubmed ID: 25621825
IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.
Frontiers in immunology , 2015 | Pubmed ID: 26834739
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.
PloS one , 2016 | Pubmed ID: 27171183
Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature.
Inflammatory bowel diseases Sep, 2016 | Pubmed ID: 27243591
Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment.
Blood Jul, 2016 | Pubmed ID: 27268088
Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2017 | Pubmed ID: 28100680
The promise of Janus kinase inhibitors in the treatment of hematological malignancies.
Cytokine Oct, 2017 | Pubmed ID: 28277287
Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.
Leukemia Aug, 2018 | Pubmed ID: 29535426
The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn's Disease-Like Ileitis.
Inflammatory bowel diseases Apr, 2018 | Pubmed ID: 29554272
Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations.
Oncotarget Apr, 2018 | Pubmed ID: 29854301
Cytokine Tuning of Intestinal Epithelial Function.
Frontiers in immunology , 2018 | Pubmed ID: 29922293
Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease?
Inflammatory bowel diseases Sep, 2018 | Pubmed ID: 30020451
Clonal Vγ6Vδ4 T cells promote IL-17-mediated immunity against skin infection.
Proceedings of the National Academy of Sciences of the United States of America May, 2019 | Pubmed ID: 31088972
IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.
The European respiratory journal Jul, 2019 | Pubmed ID: 31196943
New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia Jan, 2020 | Pubmed ID: 31439943
NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling.
Oncogene Jan, 2020 | Pubmed ID: 31586130
Mutations that collaborate with IL-7Ra signaling pathways to drive ALL.
Advances in biological regulation May, 2021 | Pubmed ID: 33578108
Trained ILC3 responses promote intestinal defense.
Science (New York, N.Y.) Feb, 2022 | Pubmed ID: 35201883
Joost J. Oppenheim (1934-2022).
Nature immunology Aug, 2022 | Pubmed ID: 35835963
IL-7: Comprehensive review.
Cytokine Dec, 2022 | Pubmed ID: 36201890
A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.
International journal of molecular sciences Jan, 2023 | Pubmed ID: 36675167
IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium.
Frontiers in immunology , 2023 | Pubmed ID: 37153622
Gisele O. L. Rodrigues1,
WenQing Li1,
Sarah D. Cramer1,2,3,
Hila Y. Winer1,
Tu Chun Hsu1,2,3,
Timothy Gower4,
Julie A. Hixon1,
Scott K. Durum1
1Cytokines and Immunity Section, Cancer Innovation Laboratory, National Cancer Institute, National Institutes of Health,
2Comparative Biomedical Scientist Training Program, NIH,
3Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, Michigan State University,
4, NCI-Frederick Laboratory Animal Sciences Program
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