Elmar Weinhold

Design of a new fluorescent cofactor for DNA methyltransferases and sequence-specific labeling of DNA.

Polycyclic aromatic DNA-base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase.

The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K.

Convenient synthesis of oligodeoxynucleotides containing 2'-deoxy-6-thioinosine.

DNA mismatch-specific base flipping by a bisacridine macrocycle.

Sequence-specific methyltransferase-induced labeling of DNA (SMILing DNA).

Sequence-specific DNA labeling using methyltransferases.

Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.

A new tool for biotechnology: AdoMet-dependent methyltransferases.

Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG).

2-Aminopurine flipped into the active site of the adenine-specific DNA methyltransferase M.TaqI: crystal structures and time-resolved fluorescence.

Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases.

Quantitative labeling of long plasmid DNA with nanometer precision.

Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2.

Sequence-specific Methyltransferase-Induced Labelling (SMILing) of plasmid DNA for studying cell transfection.

DNA labelling topologies for monitoring DNA-protein complex formation by fluorescence anisotropy.

Molecular scale architecture: engineered three- and four-way junctions.

Enzyme-directed positioning of nanoparticles on large DNA templates.

Functional reassembly of split enzymes on-site: a novel approach for highly sequence-specific targeted DNA methylation.

6-Thioguanine in DNA as CD-spectroscopic probe to study local structural changes upon protein binding.

Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation.

Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators.

Recognition of homopyrimidine mismatches by distance-constrained macrocyclic bisintercalators.

Synthesis of S-adenosyl-L-homocysteine capture compounds for selective photoinduced isolation of methyltransferases.

Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling.

Targeted DNA methylation by a DNA methyltransferase coupled to a triple helix forming oligonucleotide to down-regulate the epithelial cell adhesion molecule.

Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling.

Sequence-specific covalent labelling of DNA.

Profiling of methyltransferases and other S-Adenosyl-L-homocysteine-binding proteins by Capture Compound mass spectrometry.

Enzymatically Incorporated Genomic Tags for Optical Mapping of DNA-Binding Proteins.

Enzymatically incorporated genomic tags for optical mapping of DNA-binding proteins.

A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases.

Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases.

Toward single-molecule optical mapping of the epigenome.

Reversibly locked thionucleobase pairs in DNA to study base flipping enzymes.