Thomas Schulze

Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines.

Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder.

Can long-range microsatellite data be used to predict short-range linkage disequilibrium?

Further evidence for age of onset being an indicator for severity in bipolar disorder.

Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorder.

The European Federation of Psychiatric Trainees (EFPT)--an integral part of the European harmonisation of psychiatric education and practise.

Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22.

Is there a phenotypic difference between probands in case-control versus family-based association studies?

Age at onset in bipolar I affective disorder: further evidence for three subgroups.

Genetic linkage and association studies in bipolar affective disorder: a time for optimism.

The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease.

Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia.

Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome.

Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder.

Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees.

Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin.

Neither single-marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorder.

Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population.

Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view.

The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder.

Computer-assisted phenotype characterization for genetic research in psychiatry.

Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping.

Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.

No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.

Familial variation in episode frequency in bipolar affective disorder.

Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.

Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia.

No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder.

From degeneration to genetic susceptibility, from eugenics to genethics, from Bezugsziffer to LOD score: the history of psychiatric genetics.

Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes.

Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia.

Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.

No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia.

Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder.

No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample.

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.

Disturbed frontal gyrification within families affected with schizophrenia.

[The 5 year Young Psychiatrist Program: A contribution for the young generation in psychiatry in Germany].

No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample.

What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics.

No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia.

Premorbid adjustment in schizophrenia--an important aspect of phenotype definition.

No association between a common haplotype of the 6 and 10-repeat alleles in intron 8 and the 3'UTR of the DAT1 gene and adult attention deficit hyperactivity disorder.

No association between the serine racemase gene (SRR) and schizophrenia in a German case-control sample.

No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sample.

Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample.

Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli Arabs.

Reduction of the internal capsule in families affected with schizophrenia.

The bipolar disorder phenome database: a resource for genetic studies.

Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample.

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.

The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.

First experiences with contrast-enhanced first-pass MR perfusion imaging in patients with primary, benign cardiac masses and tumour-like lesions.

G72 and its association with major depression and neuroticism in large population-based groups from Germany.

Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin.

Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder.

The hippocampus in families with schizophrenia in relation to obstetric complications.

Identification of loci associated with schizophrenia by genome-wide association and follow-up.

No association between the D-aspartate oxidase locus and schizophrenia.

Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion.

Premorbid adjustment: a phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorder.

Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter.

Genetic predictors of response to antidepressants in the GENDEP project.

The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.

Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions.

Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project.

Dissecting the phenotype in genome-wide association studies of psychiatric illness.

No association between genetic variants at the DGCR2 gene and schizophrenia in a German sample.

Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31.

Microduplications of 16p11.2 are associated with schizophrenia.

Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia.

A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.

A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry.

Association study of 20 genetic variants at the (D)-amino acid oxidase gene in schizophrenia.

Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization.

How the green alga Chlamydomonas reinhardtii keeps time.

Association between a serotonin transporter length polymorphism and primary insomnia.

Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.

The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment.

Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP.

The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample.

Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.

High-resolution 3D non-contrast-enhanced, ECG-gated, multi-step MR angiography of the lower extremities: comparison with contrast-enhanced MR angiography.

European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onset.

The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.

Genome-wide association study of suicide attempts in mood disorder patients.

High-resolution 3D unenhanced ECG-gated respiratory-navigated MR angiography of the renal arteries: comparison with contrast-enhanced MR angiography.

Association study of the GRIA1 and CLINT1 (Epsin 4) genes in a German schizophrenia sample.

Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder.

Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.

Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling.

Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.

High frequencies of de novo CNVs in bipolar disorder and schizophrenia.

COMT val158met polymorphism and neural pain processing.

Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder.

Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.

A mega-analysis of genome-wide association studies for major depressive disorder.

Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.

SCN1A affects brain structure and the neural activity of the aging brain.

Effects of age on the structure of functional connectivity networks during episodic and working memory demand.

Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples.

Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder.

Induction and quantification of prefrontal cortical network plasticity using 5 Hz rTMS and fMRI.

Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1.

Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.

Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin.

Increased afterload induces pathological cardiac hypertrophy: a new in vitro model.

Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.

The heme-binding protein SOUL3 of Chlamydomonas reinhardtii influences size and position of the eyespot.

No evidence for an involvement of copy number variation in ABCA13 in schizophrenia, bipolar disorder, or major depressive disorder.

Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people.

The "DGPPN-Cohort": a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients.

Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction.

Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder.

Does body shaping influence brain shape? Habitual physical activity is linked to brain morphology independent of age.

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

In vitro perfusion of engineered heart tissue through endothelialized channels.

Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol.

Molecular actions and clinical pharmacogenetics of lithium therapy.

Genome-wide association study reveals two new risk loci for bipolar disorder.

Variant GADL1 and response to lithium in bipolar I disorder.

Need exists for genetic predictors of lithium response.

Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes.

Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.

How to design biospecimen identifiers and integrate relevant functionalities into your biospecimen management system.

Common and rare variant analysis in early-onset bipolar disorder vulnerability.

Smoking behaviour: investigation of the coaction of environmental and genetic risk factors.

Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue.

Neurocognitive correlates of the course of bipolar disorder.

Test-retest reliability of a new questionnaire for the retrospective assessment of long-term lithium use in bipolar disorder.

Insulin-like Growth Factor 1 Differentially Affects Lithium Sensitivity of Lymphoblastoid Cell Lines from Lithium Responder and Non-responder Bipolar Disorder Patients.

Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.

Functional outcome in major psychiatric disorders and associated clinical and psychosocial variables: A potential cross-diagnostic phenotype for further genetic investigations?

Effects of Endurance Training Combined With Cognitive Remediation on Everyday Functioning, Symptoms, and Cognition in Multiepisode Schizophrenia Patients.

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.

A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder.

Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis.

Going longitudinal in biological psychiatric research: All things considered.

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.

The Longitudinal Course of Schizophrenia Across the Lifespan: Clinical, Cognitive, and Neurobiological Aspects.

Psychopathological Symptoms Assessed by a System-Specific Approach Are Related to Global Functioning in Schizophrenic Disorders.

Effect of copy number variant burden on Global Assessment of Functioning in schizophrenia.

Human Engineered Heart Tissue: Analysis of Contractile Force.

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine.

Environmental factors, life events, and trauma in the course of bipolar disorder.

Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.

De novo Assembly and Analysis of the Chilean Pencil Catfish Trichomycterus areolatus Transcriptome.

Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders.

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.

Psychopathological Course Typology in Schizophrenia Spectrum Disorders: A Heuristic Approach in a Sample of 100 Patients.

Aims and structure of the German Research Consortium BipoLife for the study of bipolar disorder.

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder.

Pharmacogenetics of antidepressant response: A polygenic approach.

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia.