Division of Clinical Research,
Clinical Research Division
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Identification of a small molecule inhibitor of Sir2p.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2001 | Pubmed ID: 11752457
Sir2 flexes its muscle.
Developmental cell Aug, 2003 | Pubmed ID: 12919668
NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae.
Molecular and cellular biology Oct, 2003 | Pubmed ID: 12972620
Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.
The Journal of biological chemistry Dec, 2003 | Pubmed ID: 14534292
Inhibitors of Sir2: evaluation of splitomicin analogues.
Journal of medicinal chemistry May, 2004 | Pubmed ID: 15115404
Yeast as a model system for anticancer drug discovery.
Nature reviews. Cancer 06, 2004 | Pubmed ID: 15170450
Neuroscience. NAD to the rescue.
Science (New York, N.Y.) Aug, 2004 | Pubmed ID: 15310883
Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.
Combinatorial chemistry & high throughput screening Nov, 2004 | Pubmed ID: 15578928
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.
PLoS genetics Mar, 2006 | Pubmed ID: 16552446
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
Cancer research Apr, 2006 | Pubmed ID: 16618762
Pharmacogenetics: yeast lead the way.
Chemistry & biology Mar, 2006 | Pubmed ID: 16638528
Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders.
Blood Aug, 2007 | Pubmed ID: 17488876
Genetic basis of proteome variation in yeast.
Nature genetics Nov, 2007 | Pubmed ID: 17952072
Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.
The Journal of biological chemistry Dec, 2007 | Pubmed ID: 17977840
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.
PLoS genetics Feb, 2008 | Pubmed ID: 18454192
Identification and characterization of small-molecule inhibitors of hepsin.
Molecular cancer therapeutics Oct, 2008 | Pubmed ID: 18852137
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
Nature medicine Feb, 2009 | Pubmed ID: 19151729
Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19521823
Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Mar, 2011 | Pubmed ID: 20685259
Sirtuin modulators.
Handbook of experimental pharmacology , 2011 | Pubmed ID: 21879453
Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
PLoS genetics Aug, 2011 | Pubmed ID: 21901113
Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.
PLoS biology Sep, 2011 | Pubmed ID: 21909241
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
Nature Sep, 2011 | Pubmed ID: 21938067
SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.
Blood Feb, 2012 | Pubmed ID: 22219225
Proteomic classification of acute leukemias by alignment-based quantitation of LC-MS/MS data sets.
Journal of proteome research Oct, 2012 | Pubmed ID: 22900933
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.
PLoS genetics , 2013 | Pubmed ID: 23505383
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
PloS one , 2013 | Pubmed ID: 23799088
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.
Journal of medicinal chemistry Apr, 2014 | Pubmed ID: 24697269
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
Cancer discovery Nov, 2014 | Pubmed ID: 25122198
Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.
Nature May, 2015 | Pubmed ID: 25993969
SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2017 | Pubmed ID: 28049846
Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2017 | Pubmed ID: 28143937
A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2016 | Pubmed ID: 28182563
Vid Leko1,2,
Smitha Sripathy1,
Robin L. Adrianse1,
Taylor Loe1,
Angela Park1,
Uyen Lao1,
Eric J. Foss1,
Marisa S. Bartolomei3,
Antonio Bedalov1,4
1Clinical Research Division, Fred Hutchinson Cancer Research Center,
2Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health,
3Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine,
4Departments of Medicine and Biochemistry, University of Washington
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