Antonio Bedalov

Division of Clinical Research, Fred Hutchinson Cancer Research Center

Affiliated withFred Hutchinson Cancer Research Center University of Washington

Research Area

Genetics

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2018
Publication title	2018

Other Publications

Article	Year
Identification of a small molecule inhibitor of Sir2p. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11752457	2001
Sir2 flexes its muscle. Developmental cell\| PubMed ID: 12919668	2003
NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Molecular and cellular biology\| PubMed ID: 12972620	2003
Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. The Journal of biological chemistry\| PubMed ID: 14534292	2003
Inhibitors of Sir2: evaluation of splitomicin analogues. Journal of medicinal chemistry\| PubMed ID: 15115404	2004
Yeast as a model system for anticancer drug discovery. Nature reviews. Cancer\| PubMed ID: 15170450	2004
Neuroscience. NAD to the rescue. Science (New York, N.Y.)\| PubMed ID: 15310883	2004
Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast. Combinatorial chemistry & high throughput screening\| PubMed ID: 15578928	2004
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS genetics\| PubMed ID: 16552446	2006
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer research\| PubMed ID: 16618762	2006
Pharmacogenetics: yeast lead the way. Chemistry & biology\| PubMed ID: 16638528	2006
Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo diseas... Blood\| PubMed ID: 17488876	2007
Genetic basis of proteome variation in yeast. Nature genetics\| PubMed ID: 17952072	2007
Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. The Journal of biological chemistry\| PubMed ID: 17977840	2007
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS genetics\| PubMed ID: 18454192	2008
Identification and characterization of small-molecule inhibitors of hepsin. Molecular cancer therapeutics\| PubMed ID: 18852137	2008
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nature medicine\| PubMed ID: 19151729	2009
Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19521823	2009
Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 20685259	2011
Sirtuin modulators. Handbook of experimental pharmacology\| PubMed ID: 21879453	2011
Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS genetics\| PubMed ID: 21901113	2011
Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS biology\| PubMed ID: 21909241	2011
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature\| PubMed ID: 21938067	2011
SIRT1 is dispensable for function of hematopoietic stem cells in adult mice. Blood\| PubMed ID: 22219225	2012
Proteomic classification of acute leukemias by alignment-based quantitation of LC-MS/MS data sets. Journal of proteome research\| PubMed ID: 22900933	2012
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS genetics\| PubMed ID: 23505383	2013
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. PloS one\| PubMed ID: 23799088	2013
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. Journal of medicinal chemistry\| PubMed ID: 24697269	2014
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer discovery\| PubMed ID: 25122198	2014
Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature\| PubMed ID: 25993969	2015
SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28049846	2017
Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28143937	2017
A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28182563	2016