Antonio Bedalov

Identification of a small molecule inhibitor of Sir2p.

Sir2 flexes its muscle.

NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae.

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.

Inhibitors of Sir2: evaluation of splitomicin analogues.

Yeast as a model system for anticancer drug discovery.

Neuroscience. NAD to the rescue.

Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.

Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

Pharmacogenetics: yeast lead the way.

Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders.

Genetic basis of proteome variation in yeast.

Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

Identification and characterization of small-molecule inhibitors of hepsin.

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.

Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies.

Sirtuin modulators.

Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.

Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.

Proteomic classification of acute leukemias by alignment-based quantitation of LC-MS/MS data sets.

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.

Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.

The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences.

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.

A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.