Andrew R. Hoffman

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.

A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma.

Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site.

Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma.

Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor.

A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.

CTCF binding at the insulin-like growth factor-II (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues.

Bone mineral density in pediatric transplant recipients.

The histone code regulating expression of the imprinted mouse Igf2r gene.

Five weeks of insulin-like growth factor-I treatment does not alter glucose kinetics or insulin sensitivity during a hyperglycemic clamp in older women.

Epigenetic regulation of Igf2/H19 imprinting at CTCF insulator binding sites.

Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.

Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.

Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial.

IGFs and aging: is there a rationale for hormone replacement therapy?

Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing.

Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas.

Promoter-restricted histone code, not the differentially methylated DNA regions or antisense transcripts, marks the imprinting status of IGF2R in human and mouse.

Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly.

Treatment of diabetic ketoacidosis: should mode of insulin administration dictate use of intensive care facilities?

Antioxidant supplementation does not attenuate oxidative stress at high altitude.

Three weeks of caloric restriction alters protein metabolism in normal-weight, young men.

Treatment of the adult growth hormone deficiency syndrome: directions for future research.

Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency.

IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch.

Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): modulating effects of caloric restriction.

Visualization of telomerase reverse transcriptase (hTERT) promoter activity using a trimodality fusion reporter construct.

CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1.

Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy.

Directing DNA methylation to inhibit gene expression.

Prevalence, severity, and health correlates of lower urinary tract symptoms among older men: the MrOS study.

Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming.

Systematic review: the safety and efficacy of growth hormone in the healthy elderly.

Epigenetics of long-range chromatin interactions.

Effects of growth hormone and pioglitazone in viscerally obese adults with impaired glucose tolerance: a factorial clinical trial.

Generation of novel adipocyte monolayer cultures from embryonic stem cells.

Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity.

Long-term safety of recombinant human growth hormone in turner syndrome.

Do capacitively coupled electric fields accelerate tibial stress fracture healing? A randomized controlled trial.

Systematic review: the effects of growth hormone on athletic performance.

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.

Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors.

Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions.

The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) Study.

Vitamin D deficiency in older men.

Effects of an oral growth hormone secretagogue in older adults.

Association of a high mobility group gene (HMGA2) variant with bone mineral density.

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study.

The impact of hypopituitarism on function and performance in subjects with recent history of traumatic brain injury and aneurysmal subarachnoid haemorrhage.

The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men.

Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study.

Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men.

Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA.

Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study.

Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men.

Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells.

Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells.

Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men.

Sex hormones and the risk of incident prostate cancer.

Targeted tumor gene therapy based on loss of IGF2 imprinting.

Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men.

Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.

Long-range DNA interactions are specifically altered by locked nucleic acid-targeting of a CTCF binding site.

Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study.

Mortality risk in older men associated with changes in weight, lean mass, and fat mass.

Patient guide to hyperprolactinemia diagnosis and treatment.

Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.

Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts.

The Endocrine System and Sarcopenia: Potential Therapeutic Benefits.

Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.

Optimized clinical performance of growth hormone with an expanded genetic code.

Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus.

IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells.

Insulin sensitizers may attenuate lean mass loss in older men with diabetes.

Higher testosterone levels are associated with less loss of lean body mass in older men.

Long-term surveillance of growth hormone therapy.

Thyroid Function and Mortality in Older Men: A Prospective Study.