Kelly M. McNagny

Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.

Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes.

CD34 is a specific marker of mature murine mast cells.

E26 leukemia virus converts primitive erythroid cells into cycling multilineage progenitors.

Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression.

CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution.

Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells.

Hematopoietic stem cells do not engraft with absolute efficiencies.

Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins.

The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.

CD34 facilitates the development of allergic asthma.

Mast cells are an essential hematopoietic component for polyp development.

Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery.

Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation.

Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.

SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo.

Prion protein expression and release by mast cells after activation.

Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability.

Stem cells, inflammation and allergy.

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.

CD34 mediates intestinal inflammation in Salmonella-infected mice.

Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling.

CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis.

A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.

Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration.

CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis.

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.

Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.

CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.

Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes.

The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma.

IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis.

Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma.

A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue.

Requirement for core 2 O-glycans for optimal resistance to helminth infection.

SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.

Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.

Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.

Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.

Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.

Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.

Mast cells in human health and disease.

Pulmonary CD103 expression regulates airway inflammation in asthma.

Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1).

Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.

Early infancy microbial and metabolic alterations affect risk of childhood asthma.

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.

Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.

Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects.

The cell surface mucin podocalyxin regulates collective breast tumor budding.

Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.

DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.

induces a type IV hypersensitivity response in a mouse model of airway inflammation.

The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.

The Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice.

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Infection.

The first identified heterozygous nonsense mutations in podocalyxin offer new perspectives on the biology of podocytopathies.

Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation.

HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.