The Biomedical Research Centre
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Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.
The Journal of experimental medicine Jul, 2001 | Pubmed ID: 11435469
Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes.
Cells, tissues, organs , 2002 | Pubmed ID: 12021491
CD34 is a specific marker of mature murine mast cells.
Experimental hematology Oct, 2002 | Pubmed ID: 12384153
E26 leukemia virus converts primitive erythroid cells into cycling multilineage progenitors.
Blood Feb, 2003 | Pubmed ID: 12393697
Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression.
Cancer research Aug, 2004 | Pubmed ID: 15289306
CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution.
Immunity Jan, 2005 | Pubmed ID: 15664158
Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells.
Blood Jun, 2005 | Pubmed ID: 15701716
Hematopoietic stem cells do not engraft with absolute efficiencies.
Blood Jan, 2006 | Pubmed ID: 16204316
Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins.
Stem cells (Dayton, Ohio) May, 2006 | Pubmed ID: 16410385
The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.
PloS one Feb, 2007 | Pubmed ID: 17311105
CD34 facilitates the development of allergic asthma.
Blood Sep, 2007 | Pubmed ID: 17557898
Mast cells are an essential hematopoietic component for polyp development.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2007 | Pubmed ID: 18077429
Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery.
Experimental hematology Jan, 2009 | Pubmed ID: 19004540
Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation.
Biochimica et biophysica acta Aug, 2009 | Pubmed ID: 19233249
Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) May, 2009 | Pubmed ID: 19380799
SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2009 | Pubmed ID: 19542434
Prion protein expression and release by mast cells after activation.
The Journal of infectious diseases Sep, 2009 | Pubmed ID: 19642931
Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2010 | Pubmed ID: 20038636
Stem cells, inflammation and allergy.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology Dec, 2009 | Pubmed ID: 20066174
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine Jun, 2010 | Pubmed ID: 20194813
CD34 mediates intestinal inflammation in Salmonella-infected mice.
Cellular microbiology Nov, 2010 | Pubmed ID: 20497179
Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling.
Gastroenterology Oct, 2010 | Pubmed ID: 20600022
CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis.
The American journal of pathology Sep, 2010 | Pubmed ID: 20696776
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
Experimental hematology Mar, 2011 | Pubmed ID: 21193012
Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration.
PloS one Apr, 2011 | Pubmed ID: 21494591
CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis.
American journal of respiratory and critical care medicine Sep, 2011 | Pubmed ID: 21642249
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.
Nature neuroscience Sep, 2011 | Pubmed ID: 21804537
Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.
Experimental hematology Jan, 2012 | Pubmed ID: 21924221
CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.
Stem cells (Dayton, Ohio) Dec, 2011 | Pubmed ID: 21997891
Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22147703
The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.
Clinical & experimental metastasis Mar, 2012 | Pubmed ID: 22262060
Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma.
EMBO reports May, 2012 | Pubmed ID: 22422004
IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology Aug, 2012 | Pubmed ID: 22935073
Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma.
Gut microbes Mar-Apr, 2013 | Pubmed ID: 23333861
A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue.
World journal of stem cells Jan, 2013 | Pubmed ID: 23362435
Requirement for core 2 O-glycans for optimal resistance to helminth infection.
PloS one , 2013 | Pubmed ID: 23555902
SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.
PLoS pathogens , 2013 | Pubmed ID: 23950714
Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.
PloS one , 2013 | Pubmed ID: 24086539
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.
Immunity Mar, 2014 | Pubmed ID: 24613091
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.
The Journal of clinical investigation May, 2014 | Pubmed ID: 24667637
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.
The Journal of allergy and clinical immunology Apr, 2014 | Pubmed ID: 24679471
Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.
Allergy, asthma & immunology research Jul, 2014 | Pubmed ID: 24991458
Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.
The Journal of allergy and clinical immunology Jan, 2015 | Pubmed ID: 25145536
Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.
PloS one , 2014 | Pubmed ID: 25303643
Mast cells in human health and disease.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25388247
Pulmonary CD103 expression regulates airway inflammation in asthma.
American journal of physiology. Lung cellular and molecular physiology Apr, 2015 | Pubmed ID: 25681437
Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1).
The Journal of allergy and clinical immunology Sep, 2015 | Pubmed ID: 25746967
Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.
Breast cancer research : BCR Mar, 2015 | Pubmed ID: 25887862
Early infancy microbial and metabolic alterations affect risk of childhood asthma.
Science translational medicine Sep, 2015 | Pubmed ID: 26424567
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Nature communications Oct, 2015 | Pubmed ID: 26493500
Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.
European journal of immunology Jan, 2016 | Pubmed ID: 26518471
Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects.
Particle and fibre toxicology Jan, 2016 | Pubmed ID: 26758251
The cell surface mucin podocalyxin regulates collective breast tumor budding.
Breast cancer research : BCR Jan, 2016 | Pubmed ID: 26796961
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.
PloS one , 2016 | Pubmed ID: 26998906
DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.
PloS one , 2016 | Pubmed ID: 27031833
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Developmental cell Apr, 2016 | Pubmed ID: 27046831
G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.
The Journal of experimental medicine 06, 2016 | Pubmed ID: 27298444
CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.
PloS one , 2016 | Pubmed ID: 27352134
Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.
European journal of immunology 11, 2016 | Pubmed ID: 27594558
Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.
FEBS letters Feb, 2017 | Pubmed ID: 28129444
induces a type IV hypersensitivity response in a mouse model of airway inflammation.
Physiological reports Apr, 2017 | Pubmed ID: 28364028
The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.
Science immunology Sep, 2016 | Pubmed ID: 28670633
Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.
American journal of respiratory cell and molecular biology 12, 2017 | Pubmed ID: 28683207
The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.
Science immunology Sep, 2016 | Pubmed ID: 28783681
Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.
Stem cells (Dayton, Ohio) 12, 2017 | Pubmed ID: 28905451
The Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice.
Frontiers in microbiology , 2017 | Pubmed ID: 29403452
Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 02, 2018 | Pubmed ID: 29429965
IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Infection.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2019 | Pubmed ID: 30617224
The first identified heterozygous nonsense mutations in podocalyxin offer new perspectives on the biology of podocytopathies.
Clinical science (London, England : 1979) Feb, 2019 | Pubmed ID: 30737302
Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2019 | Pubmed ID: 30787191
HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.
iScience Mar, 2019 | Pubmed ID: 30818224
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