Richard Finnell

Molecular basis of environmentally induced birth defects.

Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice.

Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida.

Apolipoprotein B and apolipoprotein E genotypes and sporadic holoprosencephaly.

Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.

Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population.

DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation.

Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?

Integration of DNA sample collection into a multi-site birth defects case-control study.

Apolipoprotein E and apolipoprotein B genotypes and risk for spina bifida.

Maternal periconceptional vitamins: interactions with selected factors and congenital anomalies?

Gene expression profiling within the developing neural tube.

Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations.

Is Sonic hedgehog (SHH) a candidate gene for spina bifida? A pilot study.

Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents.

Maternal occupational chemical exposures and biotransformation genotypes as risk factors for selected congenital anomalies.

Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects.

Reduced folate carrier polymorphism (80A-->G) and neural tube defects.

Pathobiology and genetics of neural tube defects.

Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects.

Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida.

Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice.

Neural and orofacial defects in Folp1 knockout mice [corrected].

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.

Genetic dissection of hyperthermia-induced neural tube defects in mice.

Developmental outcome of levetiracetam, its major metabolite in humans, 2-pyrrolidinone N-butyric acid, and its enantiomer (R)-alpha-ethyl-oxo-pyrrolidine acetamide in a mouse model of teratogenicity.

Gene-specific monitoring of T7-based RNA amplification by real-time quantitative PCR.

Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects.

Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice.

Promoter haplotype combinations for the human PDGFRA gene are associated with risk of neural tube defects.

Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice.

Associations between polymorphisms within the thymidylate synthase gene and spina bifida.

Limb deficiency defects, MSX1, and exposure to tobacco smoke.

Teratogenicity of valproate conjugates with anticonvulsant activity in mice.

Evaluation of the Cited2 gene and risk for spina bifida and congenital heart defects.

Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects.

Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms.

Mapping a chromosomal locus for valproic acid-induced exencephaly in mice.

Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos.

Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis.

Developmental consequences of abnormal folate transport during murine heart morphogenesis.

Folate modulates Hox gene-controlled skeletal phenotypes.

Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation.

Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts.

Epidemiologic study on HFE C282Y mutation in Azerbaijan.

Investigations into the etiology of neural tube defects.

Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies.

Renal tubular reabsorption of folate mediated by folate binding protein 1.

Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.

Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population.

Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies.

Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?

Epidemiologic characteristics of anophthalmia and bilateral microphthalmia among 2.5 million births in California, 1989-1997.

Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China.

Genetic variation in the proto-oncogene SKI and risk for orofacial clefting.

Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.

Variation in IRF6 contributes to nonsyndromic cleft lip and palate.

Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes.

Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts.

Valproic acid-induced skeletal malformations: associated gene expression cascades.

Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients.

A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida.

Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts.

Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China.

3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.

Myo-inositol enhances teratogenicity of valproic acid in the mouse.

Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida.

Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos.

Nutrient effects upon embryogenesis: folate, vitamin A and iodine.

Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug.

Neural tube defects and folate: case far from closed.

Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice.

Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide.

Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation.

Another key role for the cardiac neural crest in heart development.

Screening for novel PAX3 polymorphisms and risks of spina bifida.

Infant C677T MTHFR polymorphism and severe mental retardation.

CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.

Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts.

Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.

Association between CFL1 gene polymorphisms and spina bifida risk in a California population.

A new partner for the international knockout mouse consortium.

Maternal smoking during early pregnancy, GSTP1 and EPHX1 variants, and risk of isolated orofacial clefts.

Nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring.

Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid.

Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.

Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity.

Importance of folate-homocysteine homeostasis during early embryonic development.

Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model.

Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation.

Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.

Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: a potential for a second generation drug to valproic acid.

Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida.

State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish.

Gene-nutrient interactions: importance of folic acid and vitamin B12 during early embryogenesis.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.

Autoantibodies to folate receptor during pregnancy and neural tube defect risk.

Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.

Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects.

A cannabinoid analogue of Delta9-tetrahydrocannabinol disrupts neural development in chick.

Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida.

Regulation of folate receptor 1 gene expression in the visceral endoderm.

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.

Biomarkers of exposure to combustion by-products in a human population in Shanxi, China.

Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.

Novel mutations in VANGL1 in neural tube defects.

Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model.

Transcriptional regulation of the novel Toll-like receptor Tlr13.

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): I. Obstetrical complications and change in seizure frequency: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Choline and risk of neural tube defects in a folate-fortified population.

Whole genome microarray analysis, from neonatal blood cards.

Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate.

Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.

Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark.

Novel folate binding protein-1 interactions in embryonic orofacial tissue.

Planar cell polarity pathway genes and risk for spina bifida.

HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.

Evaluation of the antiallodynic, teratogenic and pharmacokinetic profile of stereoisomers of valnoctamide, an amide derivative of a chiral isomer of valproic acid.

High-affinity folate receptor in cardiac neural crest migration: a gene knockdown model using siRNA.

Does global hypomethylation contribute to susceptibility to neural tube defects?

Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide.

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.

Teratogenic effects of antiepileptic drugs.

Folic acid in early pregnancy: a public health success story.

Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.

Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study.

Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.

Folate pathway and nonsyndromic cleft lip and palate.

Folate pathway and nonsyndromic cleft lip and palate.

A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.

Defective sumoylation pathway directs congenital heart disease.

Genetic basis of susceptibility to teratogen induced birth defects.

Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects.

Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice.

Fuz regulates craniofacial development through tissue specific responses to signaling factors.

Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.

Cannabinoid Receptor 1 Signaling in Embryo Neurodevelopment.

Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Gastroschisis among Offspring in the National Birth Defects Prevention Study.