Department of Developmental Biology
I am an MD, PhD, practicing non-invasive cardiologist and scientist. My research interest lies in cell-specific cell penetrating peptides as novel vectors for drug delivery. I have identified a cardiac targeting peptide as well as two lung targeting peptides that we are developing as novel vectors for acute and chronic conditions. My interest also lie in motile cilia especially respiratory motile cilia and effect of various drugs and interventions on ciliary function.
Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model.
Cardiovascular research , | Pubmed ID: 15158139
Perioperative risk of noncardiac surgery associated with aortic stenosis.
The American journal of cardiology , | Pubmed ID: 16054477
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association , | Pubmed ID: 16234041
Noncardiac surgery and the risk of death and other cardiovascular events in patients with hypertrophic cardiomyopathy.
Clinical cardiology , | Pubmed ID: 16506641
Endoscopic ultrasound-guided fine needle aspirate microsatellite loss analysis and pancreatic endocrine tumor outcome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association , | Pubmed ID: 16996803
Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses.
The American journal of gastroenterology , | Pubmed ID: 17029619
Impact of blood transfusions in patients presenting with anemia and suspected acute coronary syndrome.
The American journal of cardiology , | Pubmed ID: 17437739
Detectable troponin levels predict poor prognosis in patients with left ventricular dysfunction undergoing internal defibrillator implantation.
Pacing and clinical electrophysiology : PACE , | Pubmed ID: 17584264
Comparison of frequency of new-onset atrial fibrillation or flutter in patients on statins versus not on statins presenting with suspected acute coronary syndrome.
The American journal of cardiology , | Pubmed ID: 17659917
Effect of hyponatremia (<135 mEq/L) on outcome in patients with non-ST-elevation acute coronary syndrome.
The American journal of cardiology , | Pubmed ID: 17659918
Clinical significance of borderline elevated troponin I levels across different assays in patients with suspected acute coronary syndrome.
The American journal of cardiology Jul, 2009 | Pubmed ID: 19576340
Cationic and tissue-specific protein transduction domains identification, characterization, and therapeutic application.
Advances in genetics , 2010 | Pubmed ID: 20807603
Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice.
PloS one , 2010 | Pubmed ID: 20808875
Identification and characterization of tissue-specific protein transduction domains using peptide phage display.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21053137
A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2011 | Pubmed ID: 21364543
Protein transduction domains: applications for molecular medicine.
Current gene therapy , | Pubmed ID: 22920684
Association between KRAS mutation, detected in pancreatic cyst fluid, and long-term outcomes of patients.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association , | Pubmed ID: 23267865
Prevalence and significance of electrocardiographic changes and side effect profile of regadenoson compared with adenosine during myocardial perfusion imaging.
Journal of cardiovascular disease research , | Pubmed ID: 24023463
Airway ciliary dysfunction and sinopulmonary symptoms in patients with congenital heart disease.
Annals of the American Thoracic Society Nov, 2014 | Pubmed ID: 25302410
The effects of temperature and anesthetic agents on ciliary function in murine respiratory epithelia.
Frontiers in pediatrics , 2014 | Pubmed ID: 25360434
Dexmedetomidine and fentanyl exhibit temperature dependent effects on human respiratory cilia.
Frontiers in pediatrics , 2015 | Pubmed ID: 25717467
Respiratory motile cilia dysfunction in a patient with cranioectodermal dysplasia.
American journal of medical genetics. Part A Sep, 2015 | Pubmed ID: 25914204
Cell-type specific penetrating peptides: therapeutic promises and challenges.
Molecules (Basel, Switzerland) Jul, 2015 | Pubmed ID: 26205050
Establishing normative nasal nitric oxide values in infants.
Respiratory medicine Sep, 2015 | Pubmed ID: 26233707
Automated identification of abnormal respiratory ciliary motion in nasal biopsies.
Science translational medicine Aug, 2015 | Pubmed ID: 26246169
Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.
Biology open Feb, 2016 | Pubmed ID: 26883626
DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.
PLoS genetics Feb, 2016 | Pubmed ID: 26918822
Brain Dysplasia Associated with Ciliary Dysfunction in Infants with Congenital Heart Disease.
The Journal of pediatrics Nov, 2016 | Pubmed ID: 27574995
Effect of quality metric monitoring and colonoscopy performance.
Endoscopy international open , | Pubmed ID: 27747273
The complex genetics of hypoplastic left heart syndrome.
Nature genetics Jul, 2017 | Pubmed ID: 28530678
Airway ciliary dysfunction: Association with adverse postoperative outcomes in nonheterotaxy congenital heart disease patients.
The Journal of thoracic and cardiovascular surgery 02, 2018 | Pubmed ID: 29056267
Low Nasal NO in Congenital Heart Disease With Systemic Right Ventricle and Postcardiac Transplantation.
Journal of the American Heart Association Dec, 2017 | Pubmed ID: 29212650
Airway ciliary dysfunction and respiratory symptoms in patients with transposition of the great arteries.
PloS one , 2018 | Pubmed ID: 29444099
Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction.
Biomolecules 11, 2018 | Pubmed ID: 30441852
Cell Penetrating Peptides, Novel Vectors for Gene Therapy.
Pharmaceutics Mar, 2020 | Pubmed ID: 32138146
Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia.
Biomolecules Aug, 2020 | Pubmed ID: 32823934
Cardiac Targeting Peptide : From Identification to Validation to Mechanism of Transduction.
Methods in molecular biology (Clifton, N.J.) , | Pubmed ID: 33336273
Differential effect of anesthetics on mucociliary clearance in vivo in mice.
Scientific reports , | Pubmed ID: 33649513
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