Dr. Karmacharya is working at the intersection of chemical biology and stem cell biology to investigate the cellular-molecular underpinnings of psychiatric disorders
Principles and neurobiological correlates of concentrative, diffuse, and insight meditation.
Harvard review of psychiatry Jul-Aug, 2013 | Pubmed ID: 24651509
HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells.
ACS chemical biology Mar, 2015 | Pubmed ID: 25546293
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Cell reports Feb, 2015 | Pubmed ID: 25660025
Effects of LEP, LEPR, ADIPOQ, MC4R and FTO polymorphisms on dyslipidemia in Korean patients with schizophrenia who are taking clozapine.
Psychiatry research Jul, 2015 | Pubmed ID: 25841316
Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells.
Molecular and cellular neurosciences 06, 2016 | Pubmed ID: 26777134
Stem cell models of neuropsychiatric disorders.
Molecular and cellular neurosciences 06, 2016 | Pubmed ID: 27013423
Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent.
ACS chemical neuroscience 07, 2016 | Pubmed ID: 27270122
Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.
Molecular neuropsychiatry Jul, 2016 | Pubmed ID: 27606323
Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.
Journal of proteome research 02, 2017 | Pubmed ID: 28152600
Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder.
Pharmacogenomics Apr, 2017 | Pubmed ID: 28346060
Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.
ACS chemical biology 08, 2017 | Pubmed ID: 28628306
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Nature neuroscience 03, 2019 | Pubmed ID: 30718903
Identifying depression early in adolescence.
The Lancet. Child & adolescent health 04, 2019 | Pubmed ID: 30878111
HDAC6 Modulates Signaling Pathways Relevant to Synaptic Biology and Neuronal Differentiation in Human Stem-Cell-Derived Neurons.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30935091
Protocol for a systematic review of the development of depression among adolescents and young adults: psychological, biological, and contextual perspectives around the world.
Systematic reviews 07, 2019 | Pubmed ID: 31325965
Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine.
Translational psychiatry 11, 2019 | Pubmed ID: 31780643
Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia.
JAMA psychiatry Jul, 2020 | Pubmed ID: 32186681
Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder.
Genome medicine 04, 2020 | Pubmed ID: 32306996
Integrating stem cell-based experiments in clinical research.
European psychiatry : the journal of the Association of European Psychiatrists 06, 2020 | Pubmed ID: 32536357
Advances toward precision medicine for bipolar disorder: mechanisms & molecules.
Molecular psychiatry Jul, 2020 | Pubmed ID: 32636474
Mental Health Units in Correctional Facilities in the United States.
Harvard review of psychiatry Jul/Aug, 2020 | Pubmed ID: 32692089
Comparative Transcriptomic Analysis of Cerebral Organoids and Cortical Neuron Cultures Derived from Human Induced Pluripotent Stem Cells.
Stem cells and development Sep, 2020 | Pubmed ID: 32862797
A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.
Journal of psychiatric research 06, 2021 | Pubmed ID: 33857787
The Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo): Rationale, Methods, and Baseline Characteristics.
Frontiers in psychiatry , 2021 | Pubmed ID: 34234702
1Center for Genomic Medicine, Massachusetts General Hospital,
2Department of Psychiatry, Beth Israel Deaconess Medical Center,
3Chemical Biology and Therapeutic Science Program, Broad Institute of MIT and Harvard,
4Department of Psychiatry, Harvard Medical School,
5Schizophrenia and Bipolar Disorder Program, McLean Hospital
1Center for Genomic Medicine, Massachusetts General Hospital,
2Chemical Biology Program, Broad Institute of MIT & Harvard,
3Department of Psychiatry, Harvard Medical School,
4Schizophrenia and Bipolar Disorder Program, McLean Hospital,
5Program in Neuroscience, Harvard University,
6Program in Chemical Biology, Harvard University,
7, Harvard Stem Cell Institute
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