Patrick A. Lewis

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.

Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

The R1441C mutation of LRRK2 disrupts GTP hydrolysis.

The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Genetic neuropathology of Parkinson's disease.

Emerging pathways in genetic Parkinson's disease.

Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.

The function of ROCO proteins in health and disease.

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

Cancer and neurodegeneration: between the devil and the deep blue sea.

A tangled web - tau and sporadic Parkinson's disease.

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.

Gene expression in the Parkinson's disease brain.

LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.

α-Synuclein mutations cluster around a putative protein loop.

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.

Inhibition of LRRK2 kinase activity stimulates macroautophagy.

LRRK2: cause, risk, and mechanism.

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.

Rare variants in LRRK1 and Parkinson's disease.

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.

Genetic, structural, and molecular insights into the function of ras of complex proteins domains.

Computational analysis of the LRRK2 interactome.

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.

Parkinson's disease: From human genetics to clinical trials.

Genetic and phenotypic characterization of complex hereditary spastic paraplegia.

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.

Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance.

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.

Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.

LRRK2 and Autophagy.

Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3.

Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors.

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.

The LRRK2 signalling system.

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.

Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis.

LRRK2 is a negative regulator of phagosome maturation in macrophages.

Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis.

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.