Department of Molecular Neuroscience
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A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease Mar, 2002 | Pubmed ID: 11895378
Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.
The Biochemical journal Apr, 2006 | Pubmed ID: 16441239
Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.
The Journal of general virology Aug, 2006 | Pubmed ID: 16847141
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
Journal of neurochemistry Jul, 2007 | Pubmed ID: 17394548
The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Biochemical and biophysical research communications Jun, 2007 | Pubmed ID: 17442267
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2007 | Pubmed ID: 17913923
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18230735
Genetic neuropathology of Parkinson's disease.
International journal of clinical and experimental pathology , 2008 | Pubmed ID: 18784814
Emerging pathways in genetic Parkinson's disease.
The FEBS journal Dec, 2008 | Pubmed ID: 19021751
Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.
The FEBS journal Dec, 2008 | Pubmed ID: 19021752
The function of ROCO proteins in health and disease.
Biology of the cell / under the auspices of the European Cell Biology Organization Mar, 2009 | Pubmed ID: 19152505
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
Biochimica et biophysica acta Dec, 2009 | Pubmed ID: 19781641
Cancer and neurodegeneration: between the devil and the deep blue sea.
PLoS genetics , 2010 | Pubmed ID: 21203498
A tangled web - tau and sporadic Parkinson's disease.
Frontiers in psychiatry / Frontiers Research Foundation , 2010 | Pubmed ID: 21423457
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PloS one , 2011 | Pubmed ID: 21799870
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications , 2011 | Pubmed ID: 21863007
Gene expression in the Parkinson's disease brain.
Brain research bulletin Dec, 2011 | Pubmed ID: 22173063
LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?
Science signaling , 2012 | Pubmed ID: 22253261
Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
PloS one , 2012 | Pubmed ID: 22303433
GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.
Scientific reports , 2012 | Pubmed ID: 23019516
α-Synuclein mutations cluster around a putative protein loop.
Neuroscience letters Jun, 2013 | Pubmed ID: 23669636
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Sep, 2013 | Pubmed ID: 23682122
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Neurobiology of disease Oct, 2013 | Pubmed ID: 23747310
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Biochimica et biophysica acta Dec, 2013 | Pubmed ID: 23916833
LRRK2: cause, risk, and mechanism.
Journal of Parkinson's disease , 2013 | Pubmed ID: 23938341
Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.
PloS one , 2013 | Pubmed ID: 23967090
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Biochemical and biophysical research communications Nov, 2013 | Pubmed ID: 24211199
Rare variants in LRRK1 and Parkinson's disease.
Neurogenetics Mar, 2014 | Pubmed ID: 24241507
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
Human molecular genetics Sep, 2014 | Pubmed ID: 24740878
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 24942733
Genetic, structural, and molecular insights into the function of ras of complex proteins domains.
Chemistry & biology Jul, 2014 | Pubmed ID: 24981771
Computational analysis of the LRRK2 interactome.
PeerJ , 2015 | Pubmed ID: 25737818
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.
Molecular neurodegeneration Aug, 2015 | Pubmed ID: 26306801
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Journal of neurochemistry Sep, 2015 | Pubmed ID: 26375402
Parkinson's disease: From human genetics to clinical trials.
Science translational medicine Sep, 2015 | Pubmed ID: 26378242
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Brain : a journal of neurology 07, 2016 | Pubmed ID: 27217339
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Scientific reports 10, 2016 | Pubmed ID: 27731364
Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance.
Human molecular genetics Oct, 2016 | Pubmed ID: 27798102
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.
Briefings in bioinformatics Mar, 2018 | Pubmed ID: 27881428
Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.
Journal of proteome research 02, 2017 | Pubmed ID: 28004582
LRRK2 and Autophagy.
Advances in neurobiology , 2017 | Pubmed ID: 28353280
Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3.
Neurogenetics Jul, 2017 | Pubmed ID: 28391543
Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors.
Expert opinion on therapeutic targets 08, 2017 | Pubmed ID: 28609155
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.
PLoS medicine Jun, 2017 | Pubmed ID: 28609445
The LRRK2 signalling system.
Cell and tissue research Jul, 2018 | Pubmed ID: 29308544
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
Frontiers in molecular neuroscience , 2017 | Pubmed ID: 29311810
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
Proteomics May, 2018 | Pubmed ID: 29513927
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.
Bioscience reports Apr, 2018 | Pubmed ID: 29563162
Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis.
Acta neuropathologica Jun, 2018 | Pubmed ID: 29600398
LRRK2 is a negative regulator of phagosome maturation in macrophages.
The EMBO journal Jun, 2018 | Pubmed ID: 29789389
Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis.
BMC genomics Jun, 2018 | Pubmed ID: 29898659
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Brain research Jul, 2018 | Pubmed ID: 30055128
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