1991-1998 Medical School; University Medical Center Hamburg, Germany
Clinical electives at:
Duke University Medical School in Durham, North Carolina, USA
Beth Israel Deaconess Medical Center and Mount Auburn Hospital, Harvard Medical School, Boston, Massachusetts, USA
Groote Schuur Hospital, University of Cape Town, South-Africa
1994/1998 United States Medical Licensing Examination (USMLE) step 1/2
1998 – 2001 Postgraduate studies in “Molecular Biology”, University Hamburg
1999 – 2001 Resident (Clinical Pharmacology), University Erlangen-Nuremberg
2001 – 2003 Resident & Lecturer (Clinical Pharmacology), University Erlangen-Nuremberg
2003 – 2004 Lecturer & Staff Scientist (Pharmacology), University of Hamburg
2004 – 2008 Assistant professor (Juniorprofessor; Tissue Engineering), University Hamburg
2006 Board certification in Pharmacology and Toxicology
2007 Habilitation and Venia Legendi for Pharmacology and Toxicology
since 2008 W3-Professor & Director, Department of Pharmacology and Toxicology, University Medical Center Georg-August University Göttingen
Cardiac tissue engineering: implications for pediatric heart surgery.
Pediatric cardiology Jul, 2009 | Pubmed ID: 19319461
Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.
PloS one , 2010 | Pubmed ID: 21151612
Modeling myocardial growth and hypertrophy in engineered heart muscle.
Trends in cardiovascular medicine Jan, 2014 | Pubmed ID: 23953977
[Individualized stem cell therapy].
Herz Mar, 2014 | Pubmed ID: 24589843
Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.
Biomaterials Aug, 2015 | Pubmed ID: 25985155
Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.
Circulation research Aug, 2015 | Pubmed ID: 26078285
Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model.
Circulation research Sep, 2015 | Pubmed ID: 26291556
Mechanical stimulation in the engineering of heart muscle.
Advanced drug delivery reviews Jan, 2016 | Pubmed ID: 26362920
New Biologics for the Modulation of Post-Infarct Remodeling: Matricryptins.
Journal of the American College of Cardiology Sep, 2015 | Pubmed ID: 26383725
Strip and Dress the Human Heart.
Circulation research Jan, 2016 | Pubmed ID: 26837739
Translating Myocardial Remuscularization.
Circulation research 01, 2017 | Pubmed ID: 28104769
Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.
Circulation May, 2017 | Pubmed ID: 28167635
Myocardial Tissue Engineering for Regenerative Applications.
Current cardiology reports 09, 2017 | Pubmed ID: 28752277
Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation.
Stem cell research 08, 2017 | Pubmed ID: 28925362
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Annual review of pharmacology and toxicology 01, 2018 | Pubmed ID: 29029591
Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction.
Stem cell reports 02, 2018 | Pubmed ID: 29398480
Highlighting the Field of Cardiovascular Regenerative Medicine.
Molecular therapy : the journal of the American Society of Gene Therapy Jul, 2018 | Pubmed ID: 29934254
Engineered Nanoparticles Prevent Dilation of Abdominal Aortic Aneurysms.
Journal of the American College of Cardiology 11, 2018 | Pubmed ID: 30466518
Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium.
Progress in biophysics and molecular biology 07, 2019 | Pubmed ID: 30553553
Cardiac macrotissues-on-a-plate models for phenotypic drug screens.
Advanced drug delivery reviews 02, 2019 | Pubmed ID: 30902615
Physics meets medicine - At the heart of active matter.
Progress in biophysics and molecular biology 07, 2019 | Pubmed ID: 30980833
A scale model of the human ventricle.
Nature biomedical engineering 12, 2018 | Pubmed ID: 31015732
KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart.
Journal of the American College of Cardiology 10, 2019 | Pubmed ID: 31582141
Editorial commentary: Challenges to heart repair with pluripotent stem cell-derived cardiomyocytes.
Trends in cardiovascular medicine 02, 2021 | Pubmed ID: 32276084
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids.
Nature communications 07, 2020 | Pubmed ID: 32728089
Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation.
Stem cell research 10, 2020 | Pubmed ID: 33038615
Engineered Heart Muscle Models in Phenotypic Drug Screens.
Handbook of experimental pharmacology , 2021 | Pubmed ID: 33136187
Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression.
Stem cell research Jul, 2021 | Pubmed ID: 34343828
Gabriela L. Santos1,2,
Tim Meyer1,2,
Malte Tiburcy1,2,
Alisa DeGrave1,2,
Wolfram-Hubertus Zimmermann1,2,3,4,5,
Susanne Lutz1,2
1Institute of Pharmacology and Toxicology, University Medical Center Goettingen,
2, DZHK (German Center for Cardiovascular Research) partner site, Goettingen,
3Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Goettingen,
4, Center for Neurodegenerative Diseases (DZNE),
5, Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
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