Roger M. Nitsch

High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.

The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress.

CST3 genotype associated with exudative age related macular degeneration.

Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation.

Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo.

Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease.

Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease.

Active hippocampus during nonconscious memories.

Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe.

Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe.

Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons.

Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy.

beta-Amyloid induces paired helical filament-like tau filaments in tissue culture.

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.

Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42.

A functional genetic variation of the 5-HT2a receptor affects human memory.

Glucocorticoid-related genetic susceptibility for Alzheimer's disease.

Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease.

Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice.

Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease.

Low-dose cortisol for symptoms of posttraumatic stress disorder.

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.

No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits.

Immunotherapy of Alzheimer disease.

Laboratory animal welfare: cage enrichment and mouse behaviour.

Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo.

The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.

Implicit associative learning engages the hippocampus and interacts with explicit associative learning.

Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.

No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis.

The prion gene is associated with human long-term memory.

A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.

One month of human memory consolidation enhances retrieval-related hippocampal activity.

Effects of memory consolidation on human hippocampal activity during retrieval.

Active immunization trial in Abeta42-injected P301L tau transgenic mice.

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo.

Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease.

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice.

Active immunization of mice with an Abeta-Hsp70 vaccine.

Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo.

Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology.

Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.

Clinical observations with AN-1792 using TAPIR analyses.

Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo.

Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.

Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years.

Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers.

Genetic association study on colony-stimulating factor 1 in Alzheimer's disease.

Association study of cholesterol-related genes in Alzheimer's disease.

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.

Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms.

Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress.

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.

Prion protein M129V polymorphism affects retrieval-related brain activity.

Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy.

Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice.

Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82).

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.

Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice.

Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration.

RAGE does not affect amyloid pathology in transgenic ArcAbeta mice.

Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease.

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice.

Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis.

Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.

Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease.

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury.

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

Turnover of amyloid precursor protein family members determines their nuclear signaling capability.

Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.

Quantification of subcortical gray-matter vascularization using 7 Tesla time-of-flight angiography.

Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System.

RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.

Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer's disease.

Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease.

Reciprocal modulation of Aβ42 aggregation by copper and homocysteine.

Regional Fluid-Attenuated Inversion Recovery (FLAIR) at 7 Tesla correlates with amyloid beta in hippocampus and brainstem of cognitively normal elderly subjects.

Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.

Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner.

Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study.

Massachusetts Alzheimer's Disease Research Center: progress and challenges.

Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells.

Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.

Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison.

High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders.

The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals.

Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a H MRSI study at 7 Tesla.

Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease.

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients.

Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

Brain amyloid burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults.

Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old.

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study.

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.

Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury.

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.

A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.

Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.

The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation.

A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites.

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease.

Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.

Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4.

APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults.

A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain.

Reduced uptake of [11C]-ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer's dementia.

SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy.

Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation.

Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein.

Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease.

Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system.

Physical activity is associated with lower cerebral beta-amyloid and cognitive function benefits from lifetime experience-a study in exceptional aging.

Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.

Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of Tauopathy.

A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells.

Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life.

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.

Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia.