Roger M. Nitsch

Institute for Regenerative Medicine, University of Zurich

Research Area

Neuroscience

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2022

Other Publications

Article	Year
High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes. American journal of human genetics\| PubMed ID: 10631141	2000
The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11007892	2000
CST3 genotype associated with exudative age related macular degeneration. The British journal of ophthalmology\| PubMed ID: 11815350	2002
Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation. The Journal of biological chemistry\| PubMed ID: 12068009	2002
Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo. The Journal of biological chemistry\| PubMed ID: 12105192	2002
Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Psychiatric genetics\| PubMed ID: 12218659	2002
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nature medicine\| PubMed ID: 12379846	2002
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. Archives of neurology\| PubMed ID: 12533085	2003
ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease. Neurobiology of aging\| PubMed ID: 12600718	2003
Active hippocampus during nonconscious memories. Consciousness and cognition\| PubMed ID: 12617861	2003
Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe. Neuropsychologia\| PubMed ID: 12667523	2003
Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe. The European journal of neuroscience\| PubMed ID: 12670318	2003
Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons. Neurobiology of disease\| PubMed ID: 12742738	2003
Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 12762134	2003
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron\| PubMed ID: 12765607	2003
Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy. Neuroreport\| PubMed ID: 12824759	2003
beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. The Journal of biological chemistry\| PubMed ID: 12893817	2003
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. The American journal of pathology\| PubMed ID: 12937125	2003
Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42. Archives of neurology\| PubMed ID: 12975284	2003
A functional genetic variation of the 5-HT2a receptor affects human memory. Nature neuroscience\| PubMed ID: 14566344	2003
Glucocorticoid-related genetic susceptibility for Alzheimer's disease. Human molecular genetics\| PubMed ID: 14583441	2004
Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease. FEBS letters\| PubMed ID: 15043995	2004
Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiology of disease\| PubMed ID: 15056457	2004
Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 15241501	2004
Low-dose cortisol for symptoms of posttraumatic stress disorder. The American journal of psychiatry\| PubMed ID: 15285979	2004
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. Journal of cell science\| PubMed ID: 15331662	2004
No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics\| PubMed ID: 15558716	2005
Immunotherapy of Alzheimer disease. Alzheimer disease and associated disorders\| PubMed ID: 15592128	2004
Laboratory animal welfare: cage enrichment and mouse behaviour. Nature\| PubMed ID: 15602544	2004
Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo. FEBS letters\| PubMed ID: 15670841	2005
The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. The European journal of neuroscience\| PubMed ID: 15813938	2005
Implicit associative learning engages the hippocampus and interacts with explicit associative learning. Neuron\| PubMed ID: 15882649	2005
Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory. Neuroreport\| PubMed ID: 15891581	2005
No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis. The Journal of general virology\| PubMed ID: 15914866	2005
The prion gene is associated with human long-term memory. Human molecular genetics\| PubMed ID: 15987701	2005
A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. The Journal of clinical psychiatry\| PubMed ID: 16013913	2005
One month of human memory consolidation enhances retrieval-related hippocampal activity. Hippocampus\| PubMed ID: 16015623	2005
Effects of memory consolidation on human hippocampal activity during retrieval. Cortex; a journal devoted to the study of the nervous system and behavior\| PubMed ID: 16042025	2005
Active immunization trial in Abeta42-injected P301L tau transgenic mice. Neurobiology of disease\| PubMed ID: 16289870	2006
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. The EMBO journal\| PubMed ID: 16407971	2006
Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics\| PubMed ID: 16752360	2006
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiology of aging\| PubMed ID: 16876915	2007
Active immunization of mice with an Abeta-Hsp70 vaccine. Neuro-degenerative diseases\| PubMed ID: 16908970	2004
Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo. Neuro-degenerative diseases\| PubMed ID: 16908985	2004
Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology. Neuro-degenerative diseases\| PubMed ID: 16908995	2004
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. Neuro-degenerative diseases\| PubMed ID: 16909003	2005
Clinical observations with AN-1792 using TAPIR analyses. Neuro-degenerative diseases\| PubMed ID: 16909009	2005
Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo. Journal of neuroscience research\| PubMed ID: 16998901	2006
Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit. Neurobiology of disease\| PubMed ID: 17008108	2006
Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years. Brain : a journal of neurology\| PubMed ID: 17012294	2006
Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 17077159	2007
Genetic association study on colony-stimulating factor 1 in Alzheimer's disease. Neuro-degenerative diseases\| PubMed ID: 17192722	2006
Association study of cholesterol-related genes in Alzheimer's disease. Neurogenetics\| PubMed ID: 17387528	2007
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17517621	2007
Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17634359	2007
Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Molecular and cellular biology\| PubMed ID: 17984220	2008
Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiology of aging\| PubMed ID: 18403052	2010
Prion protein M129V polymorphism affects retrieval-related brain activity. Neuropsychologia\| PubMed ID: 18423780	2008
Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 18625453	2008
Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. Neurochemical research\| PubMed ID: 19115107	2009
Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). Neurochemical research\| PubMed ID: 19475506	2009
Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. Journal of cell science\| PubMed ID: 19773363	2009
Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19906959	2009
Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration. Neurobiology of aging\| PubMed ID: 19942317	2011
RAGE does not affect amyloid pathology in transgenic ArcAbeta mice. Neuro-degenerative diseases\| PubMed ID: 20145420	2009
Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a journal of neurology\| PubMed ID: 20360050	2010
Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20610758	2010
Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease. PloS one\| PubMed ID: 21483675	2011
Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice. Acta neuropathologica\| PubMed ID: 21688176	2011
Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21847134	2011
Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22302811	2012
Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neuro-degenerative diseases\| PubMed ID: 22584394	2012
Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury. European heart journal\| PubMed ID: 23008506	2012
Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging. PloS one\| PubMed ID: 23840405	2013
Turnover of amyloid precursor protein family members determines their nuclear signaling capability. PloS one\| PubMed ID: 23874953	2013
Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation. PloS one\| PubMed ID: 24086696	2013
Quantification of subcortical gray-matter vascularization using 7 Tesla time-of-flight angiography. Brain and behavior\| PubMed ID: 24392272	2013
Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System. Frontiers in aging neuroscience\| PubMed ID: 24672483	2014
RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60. Journal of Alzheimer's disease : JAD\| PubMed ID: 25024339	2014
Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer's disease. Frontiers in aging neuroscience\| PubMed ID: 25071556	2014
Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. The Journal of biological chemistry\| PubMed ID: 25118284	2014
Reciprocal modulation of Aβ42 aggregation by copper and homocysteine. Frontiers in aging neuroscience\| PubMed ID: 25249976	2014
Regional Fluid-Attenuated Inversion Recovery (FLAIR) at 7 Tesla correlates with amyloid beta in hippocampus and brainstem of cognitively normal elderly subjects. Frontiers in aging neuroscience\| PubMed ID: 25249977	2014
Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25297104	2014
Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner. Neurobiology of aging\| PubMed ID: 25702957	2015
Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study. Journal of Alzheimer's disease : JAD\| PubMed ID: 25881909	2015
Massachusetts Alzheimer's Disease Research Center: progress and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 26297855	2015
Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy. Science translational medicine\| PubMed ID: 26400911	2015
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells. Acta neuropathologica communications\| PubMed ID: 26558367	2015
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta neuropathologica\| PubMed ID: 26988843	2016
Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison. NeuroImage\| PubMed ID: 27033685	2016
High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders. Behavioural brain research\| PubMed ID: 27233823	2016
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature\| PubMed ID: 27582220	2016
Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals. The European journal of neuroscience\| PubMed ID: 27646656	2017
Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a H MRSI study at 7 Tesla. Neurobiology of aging\| PubMed ID: 27718422	2016
Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 27836896	2017
Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients. Frontiers in aging neuroscience\| PubMed ID: 28326033	2017
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease. Alzheimer's research & therapy\| PubMed ID: 28359293	2017
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. The American journal of pathology\| PubMed ID: 28408124	2017
Brain amyloid burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults. Neurobiology of aging\| PubMed ID: 29310864	2018
Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old. Neurobiology of aging\| PubMed ID: 29351872	2018
Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study. Neuro-degenerative diseases\| PubMed ID: 29402847	2018
Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients. Stem cell research\| PubMed ID: 29414602	2018
Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 30073881	2019
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models. Neurobiology of disease\| PubMed ID: 30381260	2019
A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis. Science translational medicine\| PubMed ID: 30518612	2018
Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline. Neurobiology of aging\| PubMed ID: 30738323	2019
The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation. Molecular brain\| PubMed ID: 30922360	2019
A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites. Biological chemistry\| PubMed ID: 31120852	2019
The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta neuropathologica communications\| PubMed ID: 31796114	2019
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model. Neuron\| PubMed ID: 31831332	2020
Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4. Frontiers in aging neuroscience\| PubMed ID: 32210782	2020
APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 32211498	2020
A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain. Frontiers in neuroscience\| PubMed ID: 32265643	2020
Reduced uptake of [11C]-ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer's dementia. Brain and behavior\| PubMed ID: 32304284	2020
SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy. Magma (New York, N.Y.)\| PubMed ID: 32468149	2020
Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in immunology\| PubMed ID: 32582162	2020
Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein. Journal of cell science\| PubMed ID: 32843577	2020
Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland)\| PubMed ID: 32866303	2020
Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system. PloS one\| PubMed ID: 32966331	2020
Physical activity is associated with lower cerebral beta-amyloid and cognitive function benefits from lifetime experience-a study in exceptional aging. PloS one\| PubMed ID: 33606797	2021
Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity. Biological chemistry\| PubMed ID: 33938178	2021
Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of Tauopathy. Neuro-degenerative diseases\| PubMed ID: 33975312	2020
A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells. Nature communications\| PubMed ID: 34035264	2021
Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life. Cerebral circulation - cognition and behavior\| PubMed ID: 34368788	2020
APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes. Stem cell reports\| PubMed ID: 34919811	2022
Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia. Frontiers in aging neuroscience\| PubMed ID: 35046791	2021