Institute for Regenerative Medicine
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High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.
American journal of human genetics Jan, 2000 | Pubmed ID: 10631141
The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2000 | Pubmed ID: 11007892
CST3 genotype associated with exudative age related macular degeneration.
The British journal of ophthalmology Feb, 2002 | Pubmed ID: 11815350
Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12068009
Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12105192
Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease.
Psychiatric genetics Sep, 2002 | Pubmed ID: 12218659
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.
Nature medicine Nov, 2002 | Pubmed ID: 12379846
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.
Archives of neurology Jan, 2003 | Pubmed ID: 12533085
ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease.
Neurobiology of aging May-Jun, 2003 | Pubmed ID: 12600718
Active hippocampus during nonconscious memories.
Consciousness and cognition Mar, 2003 | Pubmed ID: 12617861
Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe.
Neuropsychologia , 2003 | Pubmed ID: 12667523
Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe.
The European journal of neuroscience Mar, 2003 | Pubmed ID: 12670318
Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons.
Neurobiology of disease Apr, 2003 | Pubmed ID: 12742738
Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Mar, 2003 | Pubmed ID: 12762134
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.
Neuron May, 2003 | Pubmed ID: 12765607
Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy.
Neuroreport Jul, 2003 | Pubmed ID: 12824759
beta-Amyloid induces paired helical filament-like tau filaments in tissue culture.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12893817
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.
The American journal of pathology Sep, 2003 | Pubmed ID: 12937125
Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42.
Archives of neurology Sep, 2003 | Pubmed ID: 12975284
A functional genetic variation of the 5-HT2a receptor affects human memory.
Nature neuroscience Nov, 2003 | Pubmed ID: 14566344
Glucocorticoid-related genetic susceptibility for Alzheimer's disease.
Human molecular genetics Jan, 2004 | Pubmed ID: 14583441
Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease.
FEBS letters Mar, 2004 | Pubmed ID: 15043995
Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice.
Neurobiology of disease Apr, 2004 | Pubmed ID: 15056457
Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease.
Journal of molecular medicine (Berlin, Germany) Oct, 2004 | Pubmed ID: 15241501
Low-dose cortisol for symptoms of posttraumatic stress disorder.
The American journal of psychiatry Aug, 2004 | Pubmed ID: 15285979
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.
Journal of cell science Sep, 2004 | Pubmed ID: 15331662
No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Jan, 2005 | Pubmed ID: 15558716
Immunotherapy of Alzheimer disease.
Alzheimer disease and associated disorders Oct-Dec, 2004 | Pubmed ID: 15592128
Laboratory animal welfare: cage enrichment and mouse behaviour.
Nature Dec, 2004 | Pubmed ID: 15602544
Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo.
FEBS letters Jan, 2005 | Pubmed ID: 15670841
The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.
The European journal of neuroscience Mar, 2005 | Pubmed ID: 15813938
Implicit associative learning engages the hippocampus and interacts with explicit associative learning.
Neuron May, 2005 | Pubmed ID: 15882649
Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.
Neuroreport May, 2005 | Pubmed ID: 15891581
No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis.
The Journal of general virology Jun, 2005 | Pubmed ID: 15914866
The prion gene is associated with human long-term memory.
Human molecular genetics Aug, 2005 | Pubmed ID: 15987701
A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.
The Journal of clinical psychiatry Jul, 2005 | Pubmed ID: 16013913
One month of human memory consolidation enhances retrieval-related hippocampal activity.
Hippocampus , 2005 | Pubmed ID: 16015623
Effects of memory consolidation on human hippocampal activity during retrieval.
Cortex; a journal devoted to the study of the nervous system and behavior Aug, 2005 | Pubmed ID: 16042025
Active immunization trial in Abeta42-injected P301L tau transgenic mice.
Neurobiology of disease Apr, 2006 | Pubmed ID: 16289870
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo.
The EMBO journal Jan, 2006 | Pubmed ID: 16407971
Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Jul, 2006 | Pubmed ID: 16752360
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice.
Neurobiology of aging Sep, 2007 | Pubmed ID: 16876915
Active immunization of mice with an Abeta-Hsp70 vaccine.
Neuro-degenerative diseases , 2004 | Pubmed ID: 16908970
Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo.
Neuro-degenerative diseases , 2004 | Pubmed ID: 16908985
Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology.
Neuro-degenerative diseases , 2004 | Pubmed ID: 16908995
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
Neuro-degenerative diseases , 2005 | Pubmed ID: 16909003
Clinical observations with AN-1792 using TAPIR analyses.
Neuro-degenerative diseases , 2005 | Pubmed ID: 16909009
Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo.
Journal of neuroscience research Dec, 2006 | Pubmed ID: 16998901
Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.
Neurobiology of disease Dec, 2006 | Pubmed ID: 17008108
Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years.
Brain : a journal of neurology Nov, 2006 | Pubmed ID: 17012294
Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers.
Cerebral cortex (New York, N.Y. : 1991) Aug, 2007 | Pubmed ID: 17077159
Genetic association study on colony-stimulating factor 1 in Alzheimer's disease.
Neuro-degenerative diseases , 2006 | Pubmed ID: 17192722
Association study of cholesterol-related genes in Alzheimer's disease.
Neurogenetics Aug, 2007 | Pubmed ID: 17387528
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America May, 2007 | Pubmed ID: 17517621
Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2007 | Pubmed ID: 17634359
Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress.
Molecular and cellular biology Jan, 2008 | Pubmed ID: 17984220
Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.
Neurobiology of aging Jan, 2010 | Pubmed ID: 18403052
Prion protein M129V polymorphism affects retrieval-related brain activity.
Neuropsychologia , 2008 | Pubmed ID: 18423780
Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Jul, 2008 | Pubmed ID: 18625453
Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice.
Neurochemical research Jun, 2009 | Pubmed ID: 19115107
Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82).
Neurochemical research Aug, 2009 | Pubmed ID: 19475506
Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.
Journal of cell science Oct, 2009 | Pubmed ID: 19773363
Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2009 | Pubmed ID: 19906959
Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration.
Neurobiology of aging Oct, 2011 | Pubmed ID: 19942317
RAGE does not affect amyloid pathology in transgenic ArcAbeta mice.
Neuro-degenerative diseases , 2009 | Pubmed ID: 20145420
Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.
Brain : a journal of neurology May, 2010 | Pubmed ID: 20360050
Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2010 | Pubmed ID: 20610758
Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease.
PloS one Apr, 2011 | Pubmed ID: 21483675
Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice.
Acta neuropathologica Sep, 2011 | Pubmed ID: 21688176
Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Dec, 2011 | Pubmed ID: 21847134
Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2012 | Pubmed ID: 22302811
Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease.
Neuro-degenerative diseases , 2012 | Pubmed ID: 22584394
Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury.
European heart journal Sep, 2012 | Pubmed ID: 23008506
Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.
PloS one , 2013 | Pubmed ID: 23840405
Turnover of amyloid precursor protein family members determines their nuclear signaling capability.
PloS one , 2013 | Pubmed ID: 23874953
Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.
PloS one , 2013 | Pubmed ID: 24086696
Quantification of subcortical gray-matter vascularization using 7 Tesla time-of-flight angiography.
Brain and behavior Sep, 2013 | Pubmed ID: 24392272
Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System.
Frontiers in aging neuroscience , 2014 | Pubmed ID: 24672483
RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.
Journal of Alzheimer's disease : JAD , 2014 | Pubmed ID: 25024339
Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer's disease.
Frontiers in aging neuroscience , 2014 | Pubmed ID: 25071556
Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease.
The Journal of biological chemistry Sep, 2014 | Pubmed ID: 25118284
Reciprocal modulation of Aβ42 aggregation by copper and homocysteine.
Frontiers in aging neuroscience , 2014 | Pubmed ID: 25249976
Regional Fluid-Attenuated Inversion Recovery (FLAIR) at 7 Tesla correlates with amyloid beta in hippocampus and brainstem of cognitively normal elderly subjects.
Frontiers in aging neuroscience , 2014 | Pubmed ID: 25249977
Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2014 | Pubmed ID: 25297104
Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner.
Neurobiology of aging Apr, 2015 | Pubmed ID: 25702957
Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study.
Journal of Alzheimer's disease : JAD , 2015 | Pubmed ID: 25881909
Massachusetts Alzheimer's Disease Research Center: progress and challenges.
Alzheimer's & dementia : the journal of the Alzheimer's Association Oct, 2015 | Pubmed ID: 26297855
Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.
Science translational medicine Sep, 2015 | Pubmed ID: 26400911
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells.
Acta neuropathologica communications Nov, 2015 | Pubmed ID: 26558367
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.
Acta neuropathologica May, 2016 | Pubmed ID: 26988843
Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison.
NeuroImage 07, 2016 | Pubmed ID: 27033685
High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders.
Behavioural brain research 09, 2016 | Pubmed ID: 27233823
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Nature 09, 2016 | Pubmed ID: 27582220
Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals.
The European journal of neuroscience 05, 2017 | Pubmed ID: 27646656
Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a H MRSI study at 7 Tesla.
Neurobiology of aging 12, 2016 | Pubmed ID: 27718422
Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease.
American journal of physiology. Heart and circulatory physiology Feb, 2017 | Pubmed ID: 27836896
Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients.
Frontiers in aging neuroscience , 2017 | Pubmed ID: 28326033
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.
Alzheimer's research & therapy Mar, 2017 | Pubmed ID: 28359293
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
The American journal of pathology Jun, 2017 | Pubmed ID: 28408124
Brain amyloid burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults.
Neurobiology of aging 03, 2018 | Pubmed ID: 29310864
Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old.
Neurobiology of aging 04, 2018 | Pubmed ID: 29351872
Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study.
Neuro-degenerative diseases , 2018 | Pubmed ID: 29402847
Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.
Stem cell research 03, 2018 | Pubmed ID: 29414602
Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 11, 2019 | Pubmed ID: 30073881
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiology of disease 04, 2019 | Pubmed ID: 30381260
A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.
Science translational medicine 12, 2018 | Pubmed ID: 30518612
Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.
Neurobiology of aging 04, 2019 | Pubmed ID: 30738323
The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation.
Molecular brain 03, 2019 | Pubmed ID: 30922360
A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites.
Biological chemistry 08, 2019 | Pubmed ID: 31120852
The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease.
Acta neuropathologica communications 12, 2019 | Pubmed ID: 31796114
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Neuron 02, 2020 | Pubmed ID: 31831332
Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4.
Frontiers in aging neuroscience , 2020 | Pubmed ID: 32210782
APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults.
Alzheimer's & dementia (Amsterdam, Netherlands) , 2020 | Pubmed ID: 32211498
A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain.
Frontiers in neuroscience , 2020 | Pubmed ID: 32265643
Reduced uptake of [11C]-ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer's dementia.
Brain and behavior 06, 2020 | Pubmed ID: 32304284
SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy.
Magma (New York, N.Y.) Dec, 2020 | Pubmed ID: 32468149
Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation.
Frontiers in immunology , 2020 | Pubmed ID: 32582162
Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein.
Journal of cell science 09, 2020 | Pubmed ID: 32843577
Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 11, 2020 | Pubmed ID: 32866303
Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system.
PloS one , 2020 | Pubmed ID: 32966331
Physical activity is associated with lower cerebral beta-amyloid and cognitive function benefits from lifetime experience-a study in exceptional aging.
PloS one , 2021 | Pubmed ID: 33606797
Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.
Biological chemistry 03, 2021 | Pubmed ID: 33938178
Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of Tauopathy.
Neuro-degenerative diseases , 2020 | Pubmed ID: 33975312
A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells.
Nature communications 05, 2021 | Pubmed ID: 34035264
Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life.
Cerebral circulation - cognition and behavior , 2020 | Pubmed ID: 34368788
APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.
Stem cell reports Jan, 2022 | Pubmed ID: 34919811
Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia.
Frontiers in aging neuroscience , 2021 | Pubmed ID: 35046791
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