Richard J. Levy
Department of Anesthesiology
Columbia University Medical Center
Dr. Richard J. Levy, MD, FAAP is Professor of Anesthesiology and Pediatrics and Vice Chair for Pediatric Laboratory Research in the Department of Anesthesiology at Columbia University Medical Center. He is board certified in Anesthesiology, Pediatric Anesthesiology, Pediatrics, and Pediatric Critical Care Medicine. Dr. Levy completed his Pediatrics Residency at The Children’s Hospital of Philadelphia (CHOP) and his Anesthesiology Residency at the University of Pennsylvania. Subsequently, he completed fellowships in Pediatric Anesthesia/Cardiac Anesthesia and Pediatric Critical Care Medicine at CHOP. As a PI on an NIH K08 award, his initial area of investigation focused on mitochondrial dysfunction in the murine septic heart. Over the last several years, he has focused his investigation on the effect of different environmental exposures on the developing brain. His lab is interested in the neurotoxic and cardiotoxic effects of anesthetics and the anti-apoptotic effects of carbon monoxide. He was previously awarded an NIH R01 grant to evaluate the protective effect of carbon monoxide offsetting the pro-apoptotic effect of anesthesia in newborn mice. Dr. Levy is currently funded by NIH to evaluate mitochondrial control of protein translation in Fragile X Syndrome. He has published over 90 original manuscripts, is an associate editor for Survey of Anesthesiology, and regular reviewer for Critical Care Medicine, Anesthesia & Analgesia, Neurotoxicology and Teratology, PLOS One, the World Journal for Pediatric and Congenital Heart Surgery, and the American Journal of Physiology. He has served as an ad hoc reviewer for Science, Nature Medicine, Scientific Reports, and Nature Reviews Cardiology.
Carbon monoxide pollution and neurodevelopment: A public health concern.
Neurotoxicology and teratology May-Jun, 2015 | Pubmed ID: 25772154
Carbon monoxide modulates cytochrome oxidase activity and oxidative stress in the developing murine brain during isoflurane exposure.
Free radical biology & medicine Sep, 2015 | Pubmed ID: 26032170
Anesthesia-Related Carbon Monoxide Exposure: Toxicity and Potential Therapy.
Anesthesia and analgesia 09, 2016 | Pubmed ID: 27537758
Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children.
Journal of neurosurgical anesthesiology Oct, 2016 | Pubmed ID: 27564554
Carbon monoxide and anesthesia-induced neurotoxicity.
Neurotoxicology and teratology Mar - Apr, 2017 | Pubmed ID: 27616667
Carbon monoxide incompletely prevents isoflurane-induced defects in murine neurodevelopment.
Neurotoxicology and teratology 05, 2017 | Pubmed ID: 28131877
Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms.
Oxidative medicine and cellular longevity , 2017 | Pubmed ID: 28630658
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide.
Data in brief Aug, 2017 | Pubmed ID: 28702493
Report on the Sixth Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium, "Anesthesia and Neurodevelopment in Children".
Journal of neurosurgical anesthesiology Jan, 2019 | Pubmed ID: 30767931
The role of anaesthesiologists in lethal injection: a call to action.
Lancet (London, England) 02, 2020 | Pubmed ID: 32014115
Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 06, 2020 | Pubmed ID: 32307754
The newborn Fmr1 knockout mouse: a novel model of excess ubiquinone and closed mitochondrial permeability transition pore in the developing heart.
Pediatric research 02, 2021 | Pubmed ID: 32674111
ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome.
Cell 09, 2020 | Pubmed ID: 32795412
Insights image for "The newborn Fmr1 knockout mouse: a novel model of excess ubiquinone and closed mitochondrial permeability transition pore in the developing heart".
Pediatric research 02, 2021 | Pubmed ID: 32919395
An isolated retrograde-perfused newborn mouse heart preparation.
MethodsX , 2020 | Pubmed ID: 32983923
Isoflurane and low-level carbon monoxide exposures increase expression of pro-survival miRNA in neonatal mouse heart.
Cell stress & chaperones 05, 2021 | Pubmed ID: 33661504
Propofol toxicity in the developing mouse heart mitochondria.
Pediatric research Feb, 2022 | Pubmed ID: 35173299
Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F subcomplex.
Cell death and differentiation Mar, 2022 | Pubmed ID: 35322203
Altered brown adipose tissue mitochondrial function in newborn fragile X syndrome mice.
Mitochondrion Apr, 2022 | Pubmed ID: 35500860
JoVE Hakkında
Telif Hakkı © 2020 MyJove Corporation. Tüm hakları saklıdır