Stephen Kron

Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth.

Role of oxidative phosphorylation in Bax toxicity.

Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p.

Marker-fusion PCR for one-step mutagenesis of essential genes in yeast.

Peptide chips for the quantitative evaluation of protein kinase activity.

Sensing, signalling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth.

Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair.

Digital time-lapse microscopy of yeast cell growth.

Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism.

An essential function of yeast cyclin-dependent kinase Cdc28 maintains chromosome stability.

NuA4 subunit Yng2 function in intra-S-phase DNA damage response.

Design and implementation of algorithms for focus automation in digital imaging time-lapse microscopy.

Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans.

Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy.

Monitoring changes in the subcellular location of proteins in S. cerevisiae.

Relevance and irrelevance of DNA damage response to radiotherapy.

Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species.

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection.

Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads.

Control of the yeast cell cycle with a photocleavable alpha-factor analogue.

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.

Photocleavable peptide hydrogel arrays for MALDI-TOF analysis of kinase activity.

Non-catalytic function for ATR in the checkpoint response.

Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry.

A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates.

Phosphoprotein profiling by PA-GeLC-MS/MS.

Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.

Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns.

Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.

A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.

Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.

Cell treatment and lysis in 96-well filter-bottom plates for screening Bcr-Abl activity and inhibition in whole-cell extracts.

A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells.

Peptide reporters of kinase activity in whole cell lysates.

Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.

Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array.

A magnetic bead-based protein kinase assay with dual detection techniques.

Epigenetic modifications in double-strand break DNA damage signaling and repair.

Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS.

A pairwise chemical genetic screen identifies new inhibitors of glucose transport.

Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.

Annotator: postprocessing software for generating function-based signatures from quantitative mass spectrometry.

Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.

Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.

Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS.

Activity assay of epidermal growth factor receptor tyrosine kinase inhibitors in triple-negative breast cancer cells using peptide-conjugated magnetic beads.

CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.

The yin and yang of cyclin control by nutrients.

Kinase activation in circulating cells: opportunities for biomarkers for diagnosis and therapeutic monitoring.

DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast.

DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry.

Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.

Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations.

Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.

The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage.

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.

Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity.

The dynamic interactome of human Aha1 upon Y223 phosphorylation.

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.

Nanoparticle formulations of cisplatin for cancer therapy.

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers.

Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment.

Lipid-derived reactive aldehydes link oxidative stress to cell senescence.

Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.

Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.

HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.

Simple strategies to enhance discovery of acetylation post-translational modifications by quadrupole-orbitrap LC-MS/MS.

A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.

Multiplex three-dimensional optical mapping of tumor immune microenvironment.

Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex.

Three-Dimensional Analysis of the Human Pancreas.

The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration.

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.

Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment.

Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy.

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins.

STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability.

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.

O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors.

Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities.

Targeted antibody and cytokine cancer immunotherapies through collagen affinity.

A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence.

Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.

Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer.

Immune profiles in primary squamous cell carcinoma of the head and neck.

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.

Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis.

Targeted Covalent Inhibition of Telomerase.

Small-molecule drug repurposing to target DNA damage repair and response pathways.

A toolkit for bioimaging using near-infrared AgInS/ZnS quantum dots.

Subcellular localization of the J-protein Sis1 regulates the heat shock response.

Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.

Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells.

Multiplexed Tissue Tomography.

UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry.

Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.

Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation.

Polyphosphate degradation by Nudt3-Zn mediates oxidative stress response.

Genomic studies controvert the existence of the CUX1 p75 isoform.

TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks.

Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors.