Stephen Kron

Department of Molecular Genetics and Cell Biology, University of Chicago

Research Area

Cancer Research

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth. Molecular biology of the cell\| PubMed ID: 10512868	1999
Role of oxidative phosphorylation in Bax toxicity. Molecular and cellular biology\| PubMed ID: 10779348	2000
Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p. Molecular biology of the cell\| PubMed ID: 11694591	2001
Marker-fusion PCR for one-step mutagenesis of essential genes in yeast. Yeast (Chichester, England)\| PubMed ID: 11788969	2002
Peptide chips for the quantitative evaluation of protein kinase activity. Nature biotechnology\| PubMed ID: 11875428	2002
Sensing, signalling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth. Microbiology (Reading, England)\| PubMed ID: 11932437	2002
Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair. Journal of cell science\| PubMed ID: 11950891	2002
Digital time-lapse microscopy of yeast cell growth. Methods in enzymology\| PubMed ID: 12073352	2002
Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. The Journal of biological chemistry\| PubMed ID: 12244097	2002
An essential function of yeast cyclin-dependent kinase Cdc28 maintains chromosome stability. The Journal of biological chemistry\| PubMed ID: 12359726	2002
NuA4 subunit Yng2 function in intra-S-phase DNA damage response. Molecular and cellular biology\| PubMed ID: 12417725	2002
Design and implementation of algorithms for focus automation in digital imaging time-lapse microscopy. Cytometry\| PubMed ID: 12454979	2002
Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans. Eukaryotic cell\| PubMed ID: 12796285	2003
Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. The Journal of biological chemistry\| PubMed ID: 14561744	2004
Monitoring changes in the subcellular location of proteins in S. cerevisiae. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 14970663	2004
Relevance and irrelevance of DNA damage response to radiotherapy. DNA repair\| PubMed ID: 15279813	2004
Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species. The Journal of cell biology\| PubMed ID: 15289493	2004
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Molecular and cellular biology\| PubMed ID: 16166626	2005
Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection. Journal of proteome research\| PubMed ID: 16212443	2005
Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads. Analytical biochemistry\| PubMed ID: 16236241	2005
Control of the yeast cell cycle with a photocleavable alpha-factor analogue. Angewandte Chemie (International ed. in English)\| PubMed ID: 16937420	2006
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16940359	2006
Photocleavable peptide hydrogel arrays for MALDI-TOF analysis of kinase activity. The Analyst\| PubMed ID: 17003856	2006
Non-catalytic function for ATR in the checkpoint response. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17721080	2007
Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry. Journal of mass spectrometry : JMS\| PubMed ID: 18064576	2008
A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates. Analytical biochemistry\| PubMed ID: 18194660	2008
Phosphoprotein profiling by PA-GeLC-MS/MS. Journal of proteome research\| PubMed ID: 18510356	2008
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. Nature chemical biology\| PubMed ID: 18516048	2008
Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns. Molecular & cellular proteomics : MCP\| PubMed ID: 19435713	2009
Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase. Cell division\| PubMed ID: 19566963	2009
A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1. Gene\| PubMed ID: 19647054	2009
Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping. DNA repair\| PubMed ID: 19880356	2009
Cell treatment and lysis in 96-well filter-bottom plates for screening Bcr-Abl activity and inhibition in whole-cell extracts. Journal of biomolecular screening\| PubMed ID: 20237206	2010
A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells. Molecular cancer therapeutics\| PubMed ID: 20423990	2010
Peptide reporters of kinase activity in whole cell lysates. Biopolymers\| PubMed ID: 20593469	2010
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer research\| PubMed ID: 20610628	2010
Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array. Biosensors & bioelectronics\| PubMed ID: 20729058	2010
A magnetic bead-based protein kinase assay with dual detection techniques. Analytical biochemistry\| PubMed ID: 20807497	2011
Epigenetic modifications in double-strand break DNA damage signaling and repair. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20823147	2010
Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS. Bioconjugate chemistry\| PubMed ID: 20860375	2010
A pairwise chemical genetic screen identifies new inhibitors of glucose transport. Chemistry & biology\| PubMed ID: 21338919	2011
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation. Molecular cancer therapeutics\| PubMed ID: 21571912	2011
Annotator: postprocessing software for generating function-based signatures from quantitative mass spectrometry. Journal of proteome research\| PubMed ID: 22224429	2012
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22334019	2012
Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors. BMC cancer\| PubMed ID: 22433462	2012
Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS. Molecular bioSystems\| PubMed ID: 22772337	2012
Activity assay of epidermal growth factor receptor tyrosine kinase inhibitors in triple-negative breast cancer cells using peptide-conjugated magnetic beads. Assay and drug development technologies\| PubMed ID: 22994968	2013
CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell\| PubMed ID: 23217712	2012
The yin and yang of cyclin control by nutrients. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23470456	2013
Kinase activation in circulating cells: opportunities for biomarkers for diagnosis and therapeutic monitoring. Expert opinion on medical diagnostics\| PubMed ID: 23485115	2008
DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast. DNA repair\| PubMed ID: 23835406	2013
DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry. Chembiochem : a European journal of chemical biology\| PubMed ID: 24375983	2014
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. Journal of proteomics\| PubMed ID: 25452130	2015
Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Human molecular genetics\| PubMed ID: 25948554	2015
Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence. International journal of high throughput screening\| PubMed ID: 26097382	2011
The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage. Data in brief\| PubMed ID: 26217697	2015
c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell reports\| PubMed ID: 26235616	2015
Linking Cancer Metabolism to DNA Repair and Accelerated Senescence. Molecular cancer research : MCR\| PubMed ID: 26538285	2016
Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity. Cell reports\| PubMed ID: 26586425	2015
The dynamic interactome of human Aha1 upon Y223 phosphorylation. Data in brief\| PubMed ID: 26693507	2015
Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Cell reports\| PubMed ID: 26804907	2016
Nanoparticle formulations of cisplatin for cancer therapy. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 26848041	2016
Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers. Oncotarget\| PubMed ID: 27129153	2016
Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment. Molecular pharmaceutics\| PubMed ID: 27560921	2016
Lipid-derived reactive aldehydes link oxidative stress to cell senescence. Cell death & disease\| PubMed ID: 27607581	2016
Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis. Scientific reports\| PubMed ID: 28720834	2017
Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28987882	2017
HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation. Molecular cancer therapeutics\| PubMed ID: 29030460	2018
Simple strategies to enhance discovery of acetylation post-translational modifications by quadrupole-orbitrap LC-MS/MS. Biochimica et biophysica acta. Proteins and proteomics\| PubMed ID: 29050961	2018
A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence. Cell death discovery\| PubMed ID: 29090099	2017
Multiplex three-dimensional optical mapping of tumor immune microenvironment. Scientific reports\| PubMed ID: 29208908	2017
Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex. Cancer gene therapy\| PubMed ID: 29255216	2018
Three-Dimensional Analysis of the Human Pancreas. Endocrinology\| PubMed ID: 29390052	2018
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration. Scientific reports\| PubMed ID: 30087414	2018
Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30224481	2018
Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment. Molecular cancer therapeutics\| PubMed ID: 30322947	2019
Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 30401959	2019
Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 30411856	2018
STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability. Cancer research\| PubMed ID: 30482772	2019
The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic acids research\| PubMed ID: 30812030	2019
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors. Molecular cancer research : MCR\| PubMed ID: 30885991	2019
Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities. Cancer journal (Sudbury, Mass.)\| PubMed ID: 30896532	2019
Targeted antibody and cytokine cancer immunotherapies through collagen affinity. Science translational medicine\| PubMed ID: 30971453	2019
A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence. BMC genomics\| PubMed ID: 30987592	2019
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex. Experimental & molecular medicine\| PubMed ID: 30992425	2019
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence. Journal of cell science\| PubMed ID: 31189537	2019
Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Molecular oncology\| PubMed ID: 31225926	2019
Immune profiles in primary squamous cell carcinoma of the head and neck. Oral oncology\| PubMed ID: 31422218	2019
The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic acids research\| PubMed ID: 31511892	2019
Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis. Biochimica et biophysica acta. Proteins and proteomics\| PubMed ID: 31964485	2020
Targeted Covalent Inhibition of Telomerase. ACS chemical biology\| PubMed ID: 32017522	2020
Small-molecule drug repurposing to target DNA damage repair and response pathways. Seminars in cancer biology\| PubMed ID: 32113999	2021
A toolkit for bioimaging using near-infrared AgInS/ZnS quantum dots. Journal of materials chemistry. B\| PubMed ID: 32262876	2015
Subcellular localization of the J-protein Sis1 regulates the heat shock response. The Journal of cell biology\| PubMed ID: 33326013	2021
Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons. Cell chemical biology\| PubMed ID: 33352117	2021
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. Journal of the National Cancer Institute\| PubMed ID: 33792717	2021
Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell biochemistry and biophysics\| PubMed ID: 34085165	2021
Multiplexed Tissue Tomography. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34331280	2021
UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34331291	2021
Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms. Blood\| PubMed ID: 34473231	2021
Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation. PLoS pathogens\| PubMed ID: 34724007	2021
Polyphosphate degradation by Nudt3-Zn mediates oxidative stress response. Cell reports\| PubMed ID: 34788624	2021
Genomic studies controvert the existence of the CUX1 p75 isoform. Scientific reports\| PubMed ID: 34997000	2022
TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35094335	2022
Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors. Endocrine-related cancer\| PubMed ID: 35171113	2022