Radislav Sedlacek

Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity.

Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases.

Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes.

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.

Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.

Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif.

Plectin controls biliary tree architecture and stability in cholestasis.

The role of immune cell subpopulations in the growth and rejection of TC-1/A9 tumors in novel mouse strains differing in the H2-D haplotype and NKC domain.

Role of in maternal mRNA turnover.

Aire-expressing ILC3-like cells in the lymph node display potent APC features.

c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells.

Fam208a orchestrates interaction protein network essential for early embryonic development and cell division.

Histone methyltransferase PRDM9 is not essential for meiosis in male mice.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.

Toll-like receptor 2 expression on c-kit cells tracks the emergence of embryonic definitive hematopoietic progenitors.

The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach.

CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling.

High-throughput discovery of genetic determinants of circadian misalignment.

Human and mouse essentiality screens as a resource for disease gene discovery.

The Deep Genome Project.

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.

Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation.

Efficient allele conversion in mouse zygotes and primary cells based on electroporation of Cre protein.

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner.

Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1.

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.

Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance.

SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB receptors.

Plectin ensures intestinal epithelial integrity and protects colon against colitis.

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation".

A resource of targeted mutant mouse lines for 5,061 genes.

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.

Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Gene.

Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility.

The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.

CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.

ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.

Deletion of TLR2 erythro-myeloid progenitors leads to embryonic lethality in mice.

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.

LAMP3 deficiency affects surfactant homeostasis in mice.

Dual role of Fam208a during zygotic cleavage and early embryonic development.

Retraction notice to "Fam208a orchestrates interaction protein network essential for early embryonic development and cell division" [Exp. Cell Res. 382 (1) (2019) 111437].

INFRAFRONTIER quality principles in systemic phenotyping.

Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.

Heterozygous Mutation Affects Glucose Tolerance in Male Rats.

The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β-mediated autoinflammatory osteomyelitis.

Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis.

Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies.

Multi-Level Approach for Comprehensive Enamel Phenotyping.

Correction to: Plectin ensures intestinal epithelial integrity and protects colon against colitis.

Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns.

Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.

Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA .

Batch alignment via retention orders for preprocessing large-scale multi-batch LC-MS experiments.

FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation.

Full Assessment of Lung Mechanics Using Computer-Controlled, Forced Oscillation Technique.

Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Gene.

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections.

LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.

Structural and functional basis of mammalian microRNA biogenesis by Dicer.

Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes.

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2.

Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein.

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.

A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity.

Variation in mouse chemical signals is genetically controlled and environmentally modulated.

Spatial Analysis of Nucleotide Metabolism: From CRISPR Knockout Cancer Cells to MALDI Imaging of Tumors.

Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.