John R. Grider

GDNF availability determines enteric neuron number by controlling precursor proliferation.

Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway.

Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA.

Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex.

Neurotransmitters mediating the intestinal peristaltic reflex in the mouse.

Gastrin-releasing peptide is a modulatory neurotransmitter of the descending phase of the peristaltic reflex.

Coexpression of Y1, Y2, and Y4 receptors in smooth muscle coupled to distinct signaling pathways.

Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB.

Differential expression of Y receptors and signaling pathways in intestinal circular and longitudinal smooth muscle.

Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod.

Brain-derived neurotrophic factor augments peristalsis by augmenting 5-HT and calcitonin gene-related peptide release.

Cross-regulation of VPAC(2) receptor desensitization by M(3) receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2.

Up-regulation of calcitonin gene-related peptide and receptor tyrosine kinase TrkB in rat bladder afferent neurons following TNBS colitis.

Autoinhibition of endothelial nitric oxide synthase (eNOS) in gut smooth muscle by nitric oxide.

Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig.

Endogenous IGF-I and alpha v beta3 integrin ligands regulate increased smooth muscle growth in TNBS-induced colitis.

Colitis induces calcitonin gene-related peptide expression and Akt activation in rat primary afferent pathways.

Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids.

Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease.

The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.

Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport.

Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice.

Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures.

Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice.

Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat.

Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis.

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.

Morphine decreases enteric neuron excitability via inhibition of sodium channels.

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.

Electrophysiological characteristics of enteric neurons isolated from the immortomouse.

Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPACâ‚‚, in gastrointestinal smooth muscle.

Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle.

TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.

Differential Expression of Multidrug-Resistance Protein 5 and Phosphodiesterase 5 and Regulation of cGMP Levels in Phasic and Tonic Smooth Muscle.

Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1.

Changes in the Expression of Smooth Muscle Contractile Proteins in TNBS- and DSS-Induced Colitis in Mice.

Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.

Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA.