Donald E. Ingber

Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation.

Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins.

A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent.

Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1.

Micropatterning tractional forces in living cells.

Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.

Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces.

Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology.

Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation.

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.

Mechanosensation through integrins: cells act locally but think globally.

Tensegrity I. Cell structure and hierarchical systems biology.

Selective chemical treatment of cellular microdomains using multiple laminar streams.

Tensegrity II. How structural networks influence cellular information processing networks.

Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells.

Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology.

Cell shape provides global control of focal adhesion assembly.

Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility.

Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles.

Geometric determinants of directional cell motility revealed using microcontact printing.

Mechanical properties of individual focal adhesions probed with a magnetic microneedle.

Mechanobiology and diseases of mechanotransduction.

Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress.

Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.

A computational tensegrity model predicts dynamic rheological behaviors in living cells.

Global cytoskeletal control of mechanotransduction in kidney epithelial cells.

Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension.

Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins.

Cell fates as high-dimensional attractor states of a complex gene regulatory network.

High-betweenness proteins in the yeast protein interaction network.

Mechanical control of tissue growth: function follows form.

Cell tension, matrix mechanics, and cancer development.

Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms.

A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP).

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells.

Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.

Evidence by molecular profiling for a placental origin of infantile hemangioma.

Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching.

Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels.

Mechanical control of tissue morphogenesis during embryological development.

Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.

Multistable and multistep dynamics in neutrophil differentiation.

Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction.

Cellular mechanotransduction: putting all the pieces together again.

Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry.

Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor.

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement.

An improved mathematical approach for determination of molecular kinetics in living cells with FRAP.

Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions.

l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty.

Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent.

Combined microfluidic-micromagnetic separation of living cells in continuous flow.

Alpha-actinin-4 is required for normal podocyte adhesion.

Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts.

Nanostructured magnetizable materials that switch cells between life and death.

A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks.

Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers.

Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering.

Tissue engineering and developmental biology: going biomimetic.

What lies at the interface of regenerative medicine and developmental biology?

Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.

Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.

Tools to study cell mechanics and mechanotransduction.

Rheological behavior of living cells is timescale-dependent.

Micromechanical control of cell and tissue development: implications for tissue engineering.

Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin.

Synaptic reorganization in scaled networks of controlled size.

Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation.

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1.

Investigating complexity of protein-protein interactions in focal adhesions.

Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.

Rho signaling and mechanical control of vascular development.

Tensegrity-based mechanosensing from macro to micro.

Can cancer be reversed by engineering the tumor microenvironment?

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells.

A multi-modular tensegrity model of an actin stress fiber.

Nanomagnetic actuation of receptor-mediated signal transduction.

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro.

Noise-driven stem cell and progenitor population dynamics.

Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix.

Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat.

Tensegrity and mechanotransduction.

Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein.

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus.

A mechanosensitive transcriptional mechanism that controls angiogenesis.

Using self-assembled monolayers to pattern ECM proteins and cells on substrates.

TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.

Micromagnetic-microfluidic blood cleansing device.

Discovery of potent and practical antiangiogenic agents inspired by cortistatin A.

Cytoskeletal control of growth and cell fate switching.

Paper-supported 3D cell culture for tissue-based bioassays.

Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells.

Carbon metabolism-mediated myogenic differentiation.

From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009.

Mechanical control of tissue and organ development.

Self-assembly of three-dimensional prestressed tensegrity structures from DNA.

Reconstituting organ-level lung functions on a chip.

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins.

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.

Multizone paper platform for 3D cell cultures.

The Wyss Institute at Harvard University.

Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.

From 3D cell culture to organs-on-chips.

Unexpected strength and toughness in chitosan-fibroin laminates inspired by insect cuticle.

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.

Forty-year journey of angiogenesis translational research.

Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning.

Polymeric nanomaterials for islet targeting and immunotherapeutic delivery.

A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.

A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells.

Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix.

Microengineered physiological biomimicry: organs-on-chips.

Lab on a chip: United States of America.

Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.

Mechanosensitive mechanisms in transcriptional regulation.

LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway.

A mini-microscope for in situ monitoring of cells.

Paxillin controls directional cell motility in response to physical cues.

Magnetic Cellular Switches.

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.

Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics.

Nogo-A is a negative regulator of CNS angiogenesis.

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment.

Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity.

SLLISWD sequence in the 10FNIII domain initiates fibronectin fibrillogenesis.

Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan.

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation.

Epoxyeicosanoids promote organ and tissue regeneration.

Organs on chips 2013.

Platform for High-Throughput Testing of the Effect of Soluble Compounds on 3D Cell Cultures.

Clear castable polyurethane elastomer for fabrication of microfluidic devices.

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems.

How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression.

Microfabrication of human organs-on-chips.

A microdevice for rapid optical detection of magnetically captured rare blood pathogens.

Quantifying cell-generated mechanical forces within living embryonic tissues.

Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells.

Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.

Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.

Mechanotransduction of fluid stresses governs 3D cell migration.

Tensegrity, cellular biophysics, and the mechanics of living systems.

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.

Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment.

Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability.

Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis.

Developing microphysiological systems for use as regulatory tools--challenges and opportunities.

Microfluidic organs-on-chips.

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics.

Engineered in vitro disease models.

Generation of biocompatible droplets for in vivo and in vitro measurement of cell-generated mechanical stresses.

Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation.

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.

Control of cancer formation by intrinsic genetic noise and microenvironmental cues.

Programed Death is Favored by Natural Selection in Spatial Systems.

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation.

Optimization of Pathogen Capture in Flowing Fluids with Magnetic Nanoparticles.

Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion.

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip.

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.

A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function.

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip.

Reverse Engineering Human Pathophysiology with Organs-on-Chips.

Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip.

A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood.

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.

Direct Bonding of Chitosan Biomaterials to Tissues Using Transglutaminase for Surgical Repair or Device Implantation.

Commendation for Exposing Key Advantage of Organ Chip Approach.

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro.

Theory and associated phenomenology for intrinsic mortality arising from natural selection.

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

New anticoagulant coatings and hemostasis assessment tools to avoid complications with pediatric left ventricular assist devices.

Reproductive endocrinology: Cycling through the menstrual cycle - an out-of-body experience.

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function.

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities.

Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery.

Mechanical induction of dentin-like differentiation by adult mouse bone marrow stromal cells using compressive scaffolds.

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.

Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale.

A Biologically Inspired, Functionally Graded End Effector for Soft Robotics Applications.

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips.

The Wyss institute: A new model for medical technology innovation and translation across the academic-industrial interface.

PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip.

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.

Rapid Prototyping of Thermoplastic Microfluidic Devices.

Microfluidic Organ-on-a-Chip Models of Human Intestine.

Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape.

Developmentally inspired human 'organs on chips'.

Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

From mechanobiology to developmentally inspired engineering.

Modelling cancer in microfluidic human organs-on-chips.

Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites.

Seeing Your Way to New Insights in Biology.

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip.

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies.

Cellular nanoscale stiffness patterns governed by intracellular forces.

Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.

Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment.

Controllable Fabrication of Inhomogeneous Microcapsules for Triggered Release by Osmotic Pressure.

Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier Transcytosis.

Reproducing human and cross-species drug toxicities using a Liver-Chip.

An antifouling coating that enables affinity-based electrochemical biosensing in complex biological fluids.

Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.

AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage.

Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips.

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.

Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow.

Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.

An Engineered Human Fc-Mannose-Binding-Lectin Captures Circulating Tumor Cells.

Human Organs-on-Chips for Virology.

Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine.

Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations.

Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis.

Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?

Rapid Coating Process Generates Omniphobic Dentures in Minutes to Reduce Biofouling.

Anomalous COVID-19 tests hinder researchers.

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.

Enabling out-of-body experiences for living organs.

Harnessing Colon Chip Technology to Identify Commensal Bacteria That Promote Host Tolerance to Infection.

Transferrin receptor targeting by de novo sheet extension.

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.

Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock.

Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism.

Simulating drug concentrations in PDMS microfluidic organ chips.

Evidence generation and reproducibility in cell and gene therapy research: A call to action.

Enabling Multiplexed Electrochemical Detection of Biomarkers with High Sensitivity in Complex Biological Samples.

Establishment of a Modular Anaerobic Human Intestine Chip.

Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results.

Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip.

Bioinspired design and optimization for thin film wearable and building cooling systems.

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip.

Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity.

Biochemical and Hematologic Reference Intervals for Anesthetized, Female, Juvenile Yorkshire Swine.

Ultrarapid Method for Coating Electrochemical Sensors with Antifouling Conductive Nanomaterials Enables Highly Sensitive Multiplexed Detection in Whole Blood.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips.

Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip.

Human organs-on-chips for disease modelling, drug development and personalized medicine.

Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip.

Interdisciplinarity and mechanobiology.

What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?

Biofabrication of Multiplexed Electrochemical Immunosensors for Simultaneous Detection of Clinical Biomarkers in Complex Fluids.

Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches.

Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction.

A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma.

PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19.

Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity.

Modeling mucus physiology and pathophysiology in human organs-on-chips.

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors.

FcMBL magnetic bead-based MALDI-TOF MS rapidly identifies paediatric blood stream infections from positive blood cultures.

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip.

Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.

Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor.

Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.

Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics.

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.

Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.

A human lung alveolus-on-a-chip model of acute radiation-induced lung injury.

Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip.

Human organ chips for regenerative pharmacology.

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases.

Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties.