Experimentica Ltd.
2 ARTICLES PUBLISHED IN JoVE
Neuroscience
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Symantas Ragauskas 1, Eva Kielczewski 2, Joseph Vance 2,3, Simon Kaja 1,4, Giedrius Kalesnykas 1
1Experimentica Ltd., 2Leica Microsystems, 3Spective LLC, 4Department of Ophthalmology, Stritch School of Medicine, Loyola University Chicago
Here, we present the usefulness of longitudinal in vivo imaging in the follow-up of morphological changes of laser-induced choroidal neovascularization in mice.
Medicine
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Maria Vähätupa 1,2, Niina Jääskeläinen 2, Marc Cerrada-Gimenez 2, Rubina Thapa 2, Tero Järvinen 1, Giedrius Kalesnykas 2, Hannele Uusitalo-Järvinen 1,3
1Faculty of Medicine and Health Technology, Tampere University & Tampere University Hospital, 2Experimentica Ltd, 3Eye Centre, Tampere University Hospital
Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.
JoVE Hakkında
Telif Hakkı © 2020 MyJove Corporation. Tüm hakları saklıdır