Accedi

Experimentica Ltd.

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model

Symantas Ragauskas¹, Eva Kielczewski², Joseph Vance^2,3, Simon Kaja^1,4, Giedrius Kalesnykas¹

¹Experimentica Ltd., ²Leica Microsystems, ³Spective LLC, ⁴Department of Ophthalmology, Stritch School of Medicine, Loyola University Chicago

Here, we present the usefulness of longitudinal in vivo imaging in the follow-up of morphological changes of laser-induced choroidal neovascularization in mice.

Medicine

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Maria Vähätupa^1,2, Niina Jääskeläinen², Marc Cerrada-Gimenez², Rubina Thapa², Tero Järvinen¹, Giedrius Kalesnykas², Hannele Uusitalo-Järvinen^1,3

¹Faculty of Medicine and Health Technology, Tampere University & Tampere University Hospital, ²Experimentica Ltd, ³Eye Centre, Tampere University Hospital

Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.