Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
2 ARTICLES PUBLISHED IN JoVE
Neuroscience
Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
Hao Chang 1, Yanshu Wang 1, Hao Wu 1, Jeremy Nathans 1,2,3
1Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 2Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 3Department of Ophthalmology, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Mammalian skin contains a diverse array of structures - such as hair follicles and nerve endings - that exhibit distinctive patterns of spatial organization. Analyzing skin as a flat mount takes advantage of the 2-dimensional geometry of this tissue to produce full-thickness high-resolution images of skin structures.
Medicine
An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment
Hao Wu 1, Ana R. Rodriguez 2, Bernd W. Spur 2, Venkat Venkataraman 1,2
1Graduate School of Biomedical Sciences, Rowan University, 2Department of Cell Biology, Rowan University School of Osteopathic Medicine
A low-cost, easy-to-use and powerful system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach induced by histamine. Blood vessel leakage, Müller cell activation and the continuity of neuronal processes are utilized to assess the damage response and its reversal with a potential drug, lipoxin A4.
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