Sanofi Pasteur Limited
2 ARTICLES PUBLISHED IN JoVE
Medicine
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Takashi Shingu 1, Mariela Jaskelioff 2, Liang Yuan 1, Zhihu Ding 3, Alexei Protopopov 4, Maria Kost-Alimova 4, Jian Hu 1
1Department of Cancer Biology, UT MD Anderson Cancer Center, 2Novartis Institutes for Biomedical Research, 3Sanofi US, 4Institute of Applied Cancer Science, UT MD Anderson Cancer Center
Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.
JoVE Core
Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
Ibrahim B. Durowoju 1, Kamaljit S. Bhandal 1, Jian Hu 1, Bruce Carpick 1, Marina Kirkitadze 1
1Analytical Research & Development, Sanofi Pasteur Limited
Differential scanning calorimetry measures the thermal transition temperature(s) and total heat energy required to denature a protein. Results obtained are used to assess the thermal stability of protein antigens in vaccine formulations.
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