Independent consultant
2 ARTICLES PUBLISHED IN JoVE
Cancer Research
Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Shirley Pepke 1, William M. Nelson 2, Greg Ver Steeg 3
1Lyrid LLC, 2Independent consultant, 3Information Sciences Institute, University of Southern California
We introduce the CorExplorer web portal, an resource for exploration of tumor RNA sequencing factors found by the machine learning algorithm CorEx (Correlation Explanation), and show how factors can be analyzed relative to survival, database annotations, protein-protein interactions, and one another to gain insight into tumor biology and therapeutic interventions.
Biology
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Ariadna Carol Illa 1,2, Sarah Baumgarten 1, Dennis Danielsen 1, Karin Larsen 3, Torben Elm 1, Peter B. Johansen 4, Tom Knudsen 5, Brian Lauritzen 1, Mikael Tranholm 6, Carsten D. Ley 1
1Global Drug Discovery, Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik
The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.
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