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Independent consultant

2 ARTICLES PUBLISHED IN JoVE

Cancer Research

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Shirley Pepke¹, William M. Nelson², Greg Ver Steeg³

¹Lyrid LLC, ²Independent consultant, ³Information Sciences Institute, University of Southern California

We introduce the CorExplorer web portal, an resource for exploration of tumor RNA sequencing factors found by the machine learning algorithm CorEx (Correlation Explanation), and show how factors can be analyzed relative to survival, database annotations, protein-protein interactions, and one another to gain insight into tumor biology and therapeutic interventions.

Biology

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Ariadna Carol Illa^1,2, Sarah Baumgarten¹, Dennis Danielsen¹, Karin Larsen³, Torben Elm¹, Peter B. Johansen⁴, Tom Knudsen⁵, Brian Lauritzen¹, Mikael Tranholm⁶, Carsten D. Ley¹

¹Global Drug Discovery, Novo Nordisk A/S, ²Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, ³Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, ⁴Independent consultant, ⁵Catalyst Biosciences, ⁶Værløse Dyreklinik

The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.