University of Arizona, Phoenix
2 ARTICLES PUBLISHED IN JoVE
Unfixed Head and Closed Skull Weight Drop Method as a Rodent Model of Mild Traumatic Brain Injury (Mtbi) for Studies of Post-Traumatic Headache (PTH)
Caroline Machado Kopruszinski 1, Trent Anderson 2, Janice Oyarzo 3, Edita Navratilova 1,3, Frank Porreca 1,3
1Department of Pharmacology, College of Medicine, University of Arizona, Tucson, 2Department of Basic Medical Sciences, College of Medicine, University of Arizona, Phoenix, 3Department of Collaborative Research, Mayo Clinic
The protocol describes a rodent model of unfixed head mild traumatic brain injury induced by a weight drop allowing for free linear and rotational impact-related forces. The dynamics of this injury are similar to concussions that occur in humans and are useful to investigate underlying mechanisms involved in post-traumatic headache.
Biology
Measurement of Endothelium-Dependent Vasorelaxation in the Mouse Thoracic Aorta Using Tensometric Small Volume Chamber Myography
Brikena Gusek 1, Robert Folk 1, Tala Curry 2, Mitra Esfandiarei 1
1Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, 2Department of Child Health, College of Medicine-Phoenix, University of Arizona, Phoenix
The present protocol describes the concepts and technical application of the tensometric myograph technique using a multi-chamber myograph system in the experimental ex vivo assessment of mouse aortic endothelial function.
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