EmoCogMeter MicroMovie Media GmbH (http://www.micromovie.com) ile işbirliği içinde geliştirilmiştir.

1.. Konular Biz psikolojik 541 işe ve somatik olarak sağlıklı erkek ve kadın denek (yaş 44.47 ± 9.41; aralığı 18-89 yıl; IQ 113.90 ± 12.73). Bütün denekler Anadili düzeyinde Almanca konuştu. Çalışma Helsinki Bildirgesi&#39;nin son sürümü ile uygun olarak yürütülen ve Alman Psikolojik Derneği Kurumsal Değerlendirme Kurulu tarafından onaylanmıştır. Tüm denekler tarama önce yazılı bilgilendirilmiş onam verdi ve katılım için iade edildi. 2. Çalışma Tasarımı EmoCogMeter, bir iPad tabanlı bir uygulama, 7 nöropsikolojik testler ve çeşitli alanlarda bilişsel işlevlerini incelemek için geliştirilmiştir içerir. Önce her bir test için, kısa bir talimat ve gösteri ekranda görüntülenen. Deneyci hiçbir sözlü talimat veya geribildirim vardı. Denekler testi tamamlamak için yaklaşık 25-30 dakika gereklioturumu ing. <ol><li> Nöropsikolojik Testler <ol><li> Öğrenme ve hafıza <ol><li> Bellek Yayılma Basamak bir dizi ile katılımcılara sunmak ve sayıları hemen ardından giriş isteyin. 2 basamak ile başlayın ve katılımcılar başarılı olursa, sayılar uzun bir listesini verebilir. <ol><li> Ya erken 5 dakika sonra veya görevi sona, denekler başarıyla 9 basamak hatırlamıyorsam. Haneli yayılma ve bu seviyeye ulaşmak için gereken toplam çalışmaların numarasını kaydedin. </li></ol></li><li> Çalışma Bellek Katılımcılar, pozitif, negatif ve nötr sözcüklerin dizileri görüntülemek ve bir kelime bir önce iki deneme olarak sunulan aynı ise tepki var. <ol><li> 5 dakika sonra görevi sonlandırın ve doğru cevapların (hit), yanlış tepkiler ve tepkilerin ortalama gecikme sayısını kaydedin. </li></ol></li></ol></li><li> Dikkat ve konsantrasyon <ol><li> Seçici Attention Stroop bir varyantı uygulayın ve yazılı renk ismi içeri görüntülenen renk mürekkep karşılık eğer yanıt konuları sormak <ol><li> 3 dakika sonra görevi sonlandırın ve doğru cevapların (hit), yanlış tepkiler, tepkiler cevapsız ve yanıtların ortalama gecikme sayısını kaydedin. </li></ol></li><li> Sürekli Dikkat Küçük bir çalışma bellek bileşeni içeren bir görevi kullanın. Ekranın merkezinde bir sözde-rasgele bir sırayla ışıklı küçük mavi ve sarı dairelerden oluşan bir daire, mevcut. <ol><li> Algılamak ve mavi-sarı-sarı dizilerinin yanıt konularını öğretmek. 4 dakika sonra görevi sonlandırın ve doğru cevapların (hit), yanlış yanıtların sayısını kaydetmek ve yanıtları kaçırdı. </li></ol></li></ol></li><li> Yönetim Fonksiyonları <ol><li> Trail Testi yapmak B Probe görev anahtarlama ve 13 sayı sıralı ve alternatif bağlamak için konuları gerektirirs ve ekranda 12 harf. Konu bir hata yaptı ve doğru bağlantı seçilmeden önce görevi devam yoksa bağlantıyı göstermek etmeyin. <ol><li> Başarıyla o kadar tamamlanmaması durumunda 90 saniye sonra görevi sonlandırın. Görevi tamamlamak için gereken toplam süreyi kaydedin. </li></ol></li><li> Hanoi Kulesi Planlama ve ara adımlar bir dizi, bir hedefe ulaşmak için yeteneğini değerlendirmek. Üç çubuklar ve daha sonra daha küçük dört diskler ile bir sürümünü kullanın. <ol><li> Onlar aşağıdaki kurallara uyarak başka bir çubuğa disklerin tüm yığını taşımak zorunda konularda bilgilendirmek: (1) Tek bir disk bir zamanda taşınmış olabilir. (2) Her bir hareket zaten çubuk üzerinde mevcut olabilecek diğer disklerin üzerine, çubuklarının birinden üst diski alma ve bir çubuk üzerine kaydırarak oluşur. (3) daha küçük bir disk yok diskte üstüne yerleştirilebilir. </li><li> Denekler 4 dakika sonra hedefe ulaşmak için başarısız olursa testi End. Rgörevi ve çözüm için gerekli hamle sayısını çözmek için gereken zaman ECORD. </li></ol></li></ol></li><li> İşleme Hızı Sembol Letter Usuller Testi Ekranın üst kısmında 9 harf ve karşılık gelen geometrik sembollerle Mevcut hedefler. Ekran alt kısmında harflerin satır ve mümkün olduğunca hızlı, her harfin altında gelen sembolünü taşımak konularını öğretmek. <ol><li> Doğru yanıtların sayısını (vurur) Tutanak, yanlış tepkiler, tepkiler ve izin verilen süre içinde yanıtların ortalama gecikme (90 sn) kaçırdı. </li></ol></li></ol></li><li> İstatistiksel analiz Çalışma belleği, seçici dikkat ve sürekli dikkat sondalama deneyleri için 100 x bir doğruluk oranı ((başarlı-false) / hedefler) tanımlanmıştır. Tüm veriler ile çok değişkenli varyans analizleri (MANOVA) kullanılarak analiz edildi arası konular yaş grubu ve cinsiyet faktörleri. GreenhouseGeisser düzeltmeler başvurunun edildied uygun olduğu. MANOVA önemli ana veya etkileşim etkilerinin ortaya eğer, ileri istatistiksel analizler t-testi karşılaştırmalar kullanılarak yapılmıştır. </li></ol>

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Yazarlar ifşa hiçbir şey yok.

Bu çalışmanın temel amacı, yaşam boyunca bilişsel fonksiyonların yaşın etkilerini araştıran bir tablet bilgisayar tabanlı uygulama kullanılabilirliğini değerlendirmektir. Hipotez olarak, denekler en nöropsikolojik alanlardaki yaşla ilgili bir düşüş gösterdi. Bu tür bellek sürede, çalışan bellek doğruluk ve seçici dikkat gibi bazı bilişsel fonksiyonlar için, düşüş orta yaşlı ve yaşlı konuları karşılaştırırken sadece gözlendi gibi, ileri yaşlarda ortaya görünüyor. Diğer...

İnsan yaşlanması her alanda bilişsel gerileme ile ilişkili, ama özellikle prefrontal korteks ve bu çalışma belleği (WM), epizodik bellek ve yürütücü işlevler gibi medial temporal lob ile ilişkili fonksiyonlar için telaffuz olabilir, (Backman ve ark. 1. , Brehmer et al. 2, Shing ve ark. 3, West 4). Buna bağlı olarak, beyin görüntüleme çalışmaları hacminde prefrontal ve mediotemporal alanlarda en belirgin (Raz ve diğ. 5,6) ve bu bölgeler içinde arasındaki bu değişmiş işlevsel yaşla ilişkili bilişsel değişiklikler (Sander et al katkıda bulunuyor olabilir gösterdi. 7 Park ve Reuter-Lorenz 8). .. Erixon-Lindroth ark 11; moleküler görüntüleme çalışmaları yaşa bağlı dopamin kayıpları çoklu bilişsel görevleri değer düşüklüğü güçlü arabulucular (Backman ve ark 9, 10 olabileceğini göstermektedir </sup&gt;, Volkow et al. 12). Yaşlılık duyuşsal ve bilişsel yetkinlikleri duygusal uyaranlara tarafından geliştirilmiş olabileceğini önemli kanıtlar vardır. Dikkat tedbirler ile ilgili olumlu valenced uyaranlara daha iyi yapmak için yaşlı yetişkinler için eğilimi, tanıma ve duygusal hafıza geliştirme yaşa bağlı pozitifliği etkisi (Charles ve ark. 13 Mather ve Knight 14, Löckenhoff ve Carstensen 15 olarak adlandırılmıştır , Grühn vd. 16 Isaacowitz vd. 17) ve ömrünün sonuna kadar motivasyon hedefleri fark yansıtıyor olabilir yaklaşımlar (Carstensen ve Löckenhoff 18). Bilişsel işlevlerin nöropsikolojik testleri genellikle iş istasyonları üzerinde kağıt-kalem testleri veya bilgisayar tabanlı testler vasıtasıyla ya yapılır, ve eski konuları test ederken zorlanabilir. Öncelikle, bozulmuş motor becerileri pa kullanımını kısıtlayabilirbaşına ve-kalem testleri ve ikincisi, eski konular genellikle klavye, fare altlığı, ya da bilgisayar tabanlı nöropsikolojik testleri sırasında uygulanan diğer giriş aygıtlarını aşina değildir. Sonuç olarak, yaşlılarda sık sık performansını düşürebilir ve bulguların geçerliliğini azaltabilir, hangi nöropsikolojik test sırasında kötü motivasyon ya da uyum göstermek. Ayrıca, kağıt ve kalem testleri yanı sıra iş istasyonları üzerinde bir bilgisayar tabanlı test daha sonra nadiren bir veritabanına aktarılır ve bir çok nedenle sadece erişilebilir olan sonuçların dokümantasyonu için sürekli eğitim ve geri bildirim için deneyci katılımın yanı sıra, ihtiyaç insan sınırlı sayıda. Böylece, nöropsikolojik testler bağları kadar önemli insan kaynakları bu &quot;geleneksel&quot; yaklaşım sonuçlarını aktarırken, hataların olasılığını artırır veri erişimi sınırlayan ve iş akışını yavaşlatır. Amacımız se araştırılması için bir tablet tabanlı uygulamayı test etmek olduVeral nöropsikolojik etki. Böyle basit bir araç için taranması ve klinik ve polikliniklerde bilişsel açıkları izlemek için hızlı ve etkili bir yöntem olabileceğini, hipotez gibi biz bir iPad uygulaması kullandı. Yaşı ne olursa olsun, konu bir deneyci gelen talimat veya geribildirim olmadan görevleri gerçekleştirmek için ve testleri tamamlamak gerekir etkin olmalıdır. Yaşı ne olursa olsun, konu bir deneyci gelen talimat veya geribildirim olmadan görevleri gerçekleştirmek için etkin olmalıdır. Biz touchpad özellikle bilgisayarlarla aşina olmayan yaşlı konularda, diğer tepki cihazlara göre daha sezgisel kullanım (örn. mouse pad veya klavye) için izin vereceğini, varsaydık. Deneyci için yararları bir standart ve zaman tasarrufu test prosedürü, veri depolama ve Analy bir veritabanı ve kolaylaştırılması için test sonuçlarının güvenli transferi içermelidir süre görev performansı için artan uyum ve motivasyon, sonuçların geçerliliğini artabilirsis.

<table border="0" cellpadding="0" cellspacing="0" width="732">
	<tbody>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">Wortschatz-Test (WST)</td>
			<td style="width:231px;">http://www.testzentrale.de/programm/wortschatztest.html</td>
			<td style="width:119px;"></td>
			<td style="width:167px;">Assessment of Intelligence</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">Berlin Affective Word List (BAWL)</td>
			<td style="width:231px;">V&#245; et al., 2009</td>
			<td style="width:119px;"></td>
			<td>Stimuli for working memory task</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">Predictive Analysis SoftWare, version 18.0</td>
			<td style="width:231px;">SPSS Inc., Chicago, IL, USA</td>
			<td style="width:119px;"></td>
			<td>Statistical Analysis</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">iPad</td>
			<td style="width:231px;">http://www.apple.com/de</td>
			<td style="width:119px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">EmoCogMeter</td>
			<td style="width:231px;">http://anem.charite.de/anem</td>
			<td style="width:119px;"></td>
			<td>Application for detection and monitoring of cognitive dysfunction</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;"></td>
			<td style="width:231px;"></td>
			<td style="width:119px;"></td>
			<td></td>
		</tr>
	</tbody>
</table>

assessment of age-related changes in cognitive functions using emocogmeter, a novel tablet-computer based approach

Bu çalışmanın temel amacı, 378 sağlıklı denek (yaş aralığı 18-89 yıl) bir örnek olarak yaşam boyunca bilişsel fonksiyonların yaşın etkilerini araştıran bir tablet bilgisayar tabanlı bir uygulama (EmoCogMeter) kullanılabilirliğini değerlendirmektir. Önceki bulgularla tutarlı biz böylece bizim tablet tabanlı uygulama kullanılabilirliğini kanıtlayan, nöropsikolojik etki (bellek, dikkat, yürütücü işlevler) geniş bir yelpazede bir yaşa bağlı bilişsel gerileme bulundu. Ne olursa olsun önce bilgisayar deneyimi, tüm yaş gruplarının konuları bir deneyci gelen talimat veya geribildirim olmadan görevleri gerçekleştirmek başardık. Artan motivasyon ve böylece potansiyel olarak uyum sonuçların geçerliliğini artırmak, görev performans için yararlı olduğu kanıtlanmıştır. Bizim umut verici bulgular algılama ve bilişsel işlev bozukluğunun izlenmesi için bir tablet tabanlı uygulama büyük klinik ve pratik potansiyelini vurguluyor.

19 denekten veri teknik sorunlar nedeniyle tespit edilememiştir. Kalan tüm denekler (N = 522) testleri tamamlanan ve 3 yaş gruplarına kümelenmiş (genç: 18-30 yıl; orta yaşlı: 31-59 yaş; old: 60-89 yıl). Bu gruptaki katılımcılar, cinsiyet ve = 378 N bir örneklem büyüklüğü elde IQ (bkz. Tablo 1) göre eşleştirilmiştir. 3 yaş gruplarındaki her nöropsikolojik testleri için performans Tablo 2&#39;de özetlenmiştir. Öğrenme ve hafız...

Watch this Scientific Journal Video about Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach at JoVE.com

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Biz biliş yaşın etkilerini araştıran bir tablet bilgisayar tabanlı bir uygulama (EmoCogMeter) kullanılabilirliğini test. Sonuçlar böylece bizim uygulamanın kullanılabilirliğini kanıtlayan, bir yaşa bağlı bilişsel gerileme gösteriyor. Bulgular algılama ve bilişsel işlev bozukluğunun izlenmesi için bir tablet tabanlı uygulama büyük klinik ve pratik potansiyelini vurguluyor.

EmoCogMeter, bir Roman Tablet bilgisayar Tabanlı Yaklaşım Kullanarak Bilişsel Fonksiyonlar Yaşa bağlı Değişikliklerin Değerlendirilmesi

The main goal of this study was to assess the usability of a tablet-computer-based application (EmoCogMeter) in investigating the effects of age on ...

assessment-age-related-changes-cognitive-functions-using-emocogmeter

Research

JoVE Journal

Behavior

13.5K Görüntüleme.  Freie Universität Berlin.  Biz biliş yaşın etkilerini araştıran bir tablet bilgisayar tabanlı bir uygulama (EmoCogMeter) kullanılabilirliğini test. Sonuçlar böylece bizim uygulamanın kullanılabilirliğini kanıtlayan, bir yaşa bağlı bilişsel gerileme gösteriyor. Bulgular algılama ve bilişsel işlev bozukluğunun izlenmesi için bir tablet tabanlı uygulama büyük klinik ve pratik potansiyelini vurguluyor. 

Video: Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Use of the Operant Orofacial Pain Assessment Device (OPAD) to Measure Changes in Nociceptive Behavior

We present an operant system for the detection of pain in awake, conscious rodents. The Orofacial Pain Assessment Device (OPAD) assesses pain behaviors in a more clinically relevant way by not relying on reflex-based measures of nociception. Food fasted, hairless (or shaved) rodents are placed into a Plexiglas chamber which has two Peltier-based thermodes that can be programmed to any temperature between 7 &deg;C and 60 &deg;C. The rodent is trained to make contact with these in order to access a reward bottle. During a session, a number of behavioral pain outcomes are automatically recorded and saved. These measures include the number of reward bottle activations (licks) and facial contact stimuli (face contacts), but custom measures like the lick/face ratio (total number of licks per session/total number of contacts) can also be created. The stimulus temperature can be set to a single temperature or multiple temperatures within a session. The OPAD is a high-throughput, easy to use operant assay which will lead to better translation of pain research in the future as it includes cortical input instead of relying on spinal reflex-based nociceptive assays.

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

We present a user-friendly, high-throughput operant system for the evaluation of pain behaviors in awake, conscious rodents. The Orofacial Pain Assessment Device (OPAD) can assess pain through a reward/conflict paradigm thus providing a more humane way of testing. This protocol will yield more clinically relevant and translational data from rodents.

Nosiseptif Davranış değişiklikler Tedbir Edimsel Orofasiyal Ağrı Değerlendirme Ölçeği (OPAD) kullanımı

We present an operant  system for the detection of pain in awake, conscious rodents. The Orofacial  Pain Assessment Device (OPAD) assesses pain behaviors ...

Davranış

The Crossmodal Congruency Task as a Means to Obtain an Objective Behavioral Measure in the Rubber Hand Illusion Paradigm

The rubber hand illusion (RHI) is a popular experimental paradigm. Participants view touch on an artificial rubber hand while the participants' own hidden hand is touched. If the viewed and felt touches are given at the same time then this is sufficient to induce the compelling experience that the rubber hand is one's own hand. The RHI can be used to investigate exactly how the brain constructs distinct body representations for one's own body. Such representations are crucial for successful interactions with the external world. To obtain a subjective measure of the RHI, researchers typically ask participants to rate statements such as "I felt as if the rubber hand were my hand". Here we demonstrate how the crossmodal congruency task can be used to obtain an objective behavioral measure within this paradigm.
The variant of the crossmodal congruency task we employ involves the presentation of tactile targets and visual distractors. Targets and distractors are spatially congruent (i.e. same finger) on some trials and incongruent (i.e. different finger) on others. The difference in performance between incongruent and congruent trials - the crossmodal congruency effect (CCE) - indexes multisensory interactions. Importantly, the CCE is modulated both by viewing a hand as well as the synchrony of viewed and felt touch which are both crucial factors for the RHI.
The use of the crossmodal congruency task within the RHI paradigm has several advantages. It is a simple behavioral measure which can be repeated many times and which can be obtained during the illusion while participants view the artificial hand. Furthermore, this measure is not susceptible to observer and experimenter biases. The combination of the RHI paradigm with the crossmodal congruency task allows in particular for the investigation of multisensory processes which are critical for modulations of body representations as in the RHI.

We demonstrate how an objective measure can be employed in the widely employed rubber hand illusion paradigm. This measure is obtained by modifying the well-established crossmodal congruency task. This task allows the investigation of multisensory processes which are critical for modulations of body representations as in the rubber hand illusion.

Kauçuk El Illusion Paradigma bir Amaç Davranış Tedbir Alınması Aracı Olarak Crossmodal Congruency Görev

The rubber hand illusion (RHI) is a popular experimental paradigm. Participants view touch on an artificial rubber hand while the participants' own hidden ...

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

The ability to adjust behavior to sudden changes in the environment develops gradually in childhood and adolescence. For example, in the Dimensional Change Card Sort task, participants switch from sorting cards one way, such as shape, to sorting them a different way, such as color. Adjusting behavior in this way exacts a small performance cost, or switch cost, such that responses are typically slower and more error-prone on switch trials in which the sorting rule changes as compared to repeat trials in which the sorting rule remains the same. The ability to flexibly adjust behavior is often said to develop gradually, in part because behavioral costs such as switch costs typically decrease with increasing age. Why aspects of higher-order cognition, such as behavioral flexibility, develop so gradually remains an open question. One hypothesis is that these changes occur in association with functional changes in broad-scale cognitive control networks. On this view, complex mental operations, such as switching, involve rapid interactions between several distributed brain regions, including those that update and maintain task rules, re-orient attention, and select behaviors. With development, functional connections between these regions strengthen, leading to faster and more efficient switching operations. The current video describes a method of testing this hypothesis through the collection and multivariate analysis of fMRI data from participants of different ages.

This video presents a method of examining age-related changes in functional connectivity of cognitive control networks engaged by targeted tasks/processes. The technique is based on multi-variate analysis of fMRI data.

Boyutsal Değişim Kartı Sıralama Performans ile Bilişsel Kontrol Ağları Associated Fonksiyonel Bağlantı yaşa bağlı farklılıklar araştırılması için Bir Yöntem

The ability to adjust behavior to sudden changes in the environment develops gradually in childhood and adolescence. For example, in the Dimensional ...

Practical Methodology of Cognitive Tasks Within a Navigational Assessment

This paper describes an approach for measuring navigation accuracy relative to cognitive skills. The methodology behind the assessment will thus be clearly outlined in a step-by-step manner. Navigational skills are important when trying to find symbols within a speech-generating device (SGD) that has a dynamic screen and taxonomical organization. The following skills have been found to impact children&#8217;s ability to find symbols when navigating within the levels of an SGD: sustained attention, categorization, cognitive flexibility, and fluid reasoning1,2. According to past studies, working memory was not correlated with navigation1,2.
The materials needed for this method include a computerized tablet, an augmentative and alternative communication application, a booklet of symbols, and the Leiter International Performance Scale-Revised (Leiter-R)3. This method has been used in two previous studies. Robillard, Mayer-Crittenden, Roy-Charland, Minor-Corriveau and B&#233;langer1 assessed typically developing children, while Rondeau, Robillard and Roy-Charland2 assessed children and adolescents with a diagnosis of Autism Spectrum Disorder. The direct observation of this method will facilitate the replication of this study for researchers. It will also help clinicians that work with children who have complex communication needs to determine the children&#8217;s ability to navigate an SGD with taxonomical categorization.

Children who have complex communication needs can benefit from the use of a speech-generating device (SGD). Cognitive skills were identified as having an impact on the ability to navigate between levels of SGDs. This protocol describes the steps needed for Speech-language Pathologists to assess cognitive skills and navigational abilities.

Bir Seyir Değerlendirilmesi içinde Bilişsel Görevler Pratik Yöntem

This paper describes an approach for measuring navigation accuracy relative to cognitive skills. The methodology behind the assessment will thus be ...

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach

Mouse is the preferred model organism for testing drugs designed to increase sociability. We present a method to quantify mouse sociability in which the test mouse is placed in a standardized apparatus and relevant behaviors are assessed in three different sessions (called session I, II, and III).
The apparatus has three compartments (see Figure 1), the left and right compartments contain an inverted cup which can house a mouse (called &#34;stimulus mouse&#34;).
In session I, the test mouse is placed in the cage and its mobility is characterized by the number of transitions made between compartments. In session II, a stimulus mouse is placed under one of the inverted cups and the sociability of the test mouse is quantified by the amounts of time it spends near the cup containing the enclosed stimulus mouse vs. the empty inverted cup. In session III, the inverted cups are removed and both mice interact freely. The sociability of the test mouse in session III is quantified by the number of social approaches it makes toward the stimulus mouse and by the number of times it avoids a social approach by the stimulus mouse.
The automated evaluation of the movie detects the nose of the test mouse, which allows the determination of all described sociability measures in session I and II (in session III, approaches are identified automatically but classified manually). To find the nose, the image of an empty cage is digitally subtracted from each frame of the movie and the resulting image is binarized to identify the mouse pixels. The mouse tail is automatically removed and the two most distant points of the remaining mouse are determined; these are close to nose and base of tail. By analyzing the motion of the mouse and using continuity arguments, the nose is identified.
<img alt="Figure 1" src="/files/ftp_upload/52508/52508fig1.jpg" /> 
Figure 1. Assessment of Sociability During 3 sessions. Session I (top): Acclimation of test mouse to the cage. Session II (middle): Test mouse moving freely in the cage while the stimulus mouse is enclosed in an inverted cup. Session III (bottom): Both test mouse and stimulus mouse are allowed to move freely and interact with each other.

This protocol describes a method to quantify mouse sociability. Mice are videotaped as they move and interact in a special cage. Movie processing allows for the automated quantification of sociability with excellent accuracy and reliability.

Bir Otomatik Görüntü İşleme Yaklaşımı ile Fare Sosyallik Deneysel Değerlendirilmesi

Mouse is the preferred model organism for testing drugs designed to increase sociability. We present a method to quantify mouse sociability in which the ...

Assessment of Social Cognition in Non-human Primates Using a Network of Computerized Automated Learning Device (ALDM) Test Systems

Fagot &#38; Paleressompoulle1 and Fagot &#38; Bonte2 have published an automated learning device (ALDM) for the study of cognitive abilities of monkeys maintained in semi-free ranging conditions. Data accumulated during the last five years have consistently demonstrated the efficiency of this protocol to investigate individual/physical cognition in monkeys, and have further shown that this procedure reduces stress level during animal testing3. This paper demonstrates that networks of ALDM can also be used to investigate different facets of social cognition and in-group expressed behaviors in monkeys, and describes three illustrative protocols developed for that purpose. The first study demonstrates how ethological assessments of social behavior and computerized assessments of cognitive performance could be integrated to investigate the effects of socially exhibited moods on the cognitive performance of individuals. The second study shows that batteries of ALDM running in parallel can provide unique information on the influence of the presence of others on task performance. Finally, the last study shows that networks of ALDM test units can also be used to study issues related to social transmission and cultural evolution. Combined together, these three studies demonstrate clearly that ALDM testing is a highly promising experimental tool for bridging the gap in the animal literature between research on individual cognition and research on social cognition.

Assessment of Social Cognition in Non-human Primates Using a Network of Computerized Automated Learning Device ALDM Test Systems

Fagot &#38; Paleressompoulle1 have published an automated learning device (ALDM) aimed at testing individual cognitive abilities in semi-free ranging monkeys. The main goal of our protocol is to use a network of ALDM test units to study social cognition in non-human primates.

Bilgisayarlı Otomatik Öğrenme Cihazı (aldm) Test Sistemleri bir Ağı Kullanma Olmayan insan Primatlar Sosyal Biliş Değerlendirilmesi

Fagot &#38; Paleressompoulle1 and Fagot &#38; Bonte2 have published an automated learning device (ALDM) for the study of cognitive abilities of monkeys ...

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging (fMRI) for extracting crucial information about the mechanism of the human brain, such methods remain insufficient to provide information about physiological processes reflecting cognitive and emotional functions at the subcortical level. In this respect, modern invasive clinical approaches in humans, such as deep brain stimulation (DBS), offer a tremendous possibility to record subcortical brain activity, namely local field potentials (LFPs) representing coherent activity of neural assemblies from localized basal ganglia or thalamic regions. Notwithstanding the fact that invasive approaches in humans are applied only after medical indication and thus recorded data correspond to altered brain circuits, valuable insight can be gained regarding the presence of intact brain functions in relation to brain oscillatory activity and the pathophysiology of disorders in response to experimental cognitive paradigms. In this direction, a growing number of DBS studies in patients with Parkinson&#39;s disease (PD) target not only motor functions but also higher level processes such as emotions, decision-making, attention, memory and sensory perception. Recent clinical trials also emphasize the role of DBS as an alternative treatment in neuropsychiatric disorders ranging from obsessive compulsive disorder (OCD) to chronic disorders of consciousness (DOC). Consequently, we focus on the use of combined invasive (LFP) and non-invasive (EEG) human brain recordings in assessing the role of cortical-subcortical structures in cognitive and emotional processing trough experimental paradigms (e.g. speech stimuli with emotional connotation or paradigms of cognitive control such as the Flanker task), for patients undergoing DBS treatment.

The present protocol aims at assessing cognitive-emotional functions in the basal ganglia by simultaneous neurophysiological recording of local field potentials and non-invasive brain cortical activity (EEG). The procedure is exemplified by the use of paradigms involving speech stimuli with emotional connotation or the Flanker task involving cognitive control.

İnsanlarda Kombine İnvaziv subkortikal ve Bilişsel Değerlendirme Non-invaziv Yüzey Nörofizyolojik Kayıtlar ve Duygusal Fonksiyonlar

In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging ...

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Much research in social psychology has investigated the impact of bodily energy need on cognition and decision-making. As such, blood glucose, the body's primary energy source, has been of special interest to researchers for years. Fluctuations in blood glucose have been linked to a variety of changes in cognitive and behavioral processes, such as self-control, political attitudes, and eating behavior. To help meet growing interest in the links between bodily energy need and these processes, this manuscript offers a simple methodology to experimentally manipulate blood glucose using a fasting procedure followed by administration of a sugar-sweetened, unsweetened, or artificially-sweetened beverage. This is followed by presentation of a method for measuring resulting changes in implicit cognition using a lexical decision-task. In this task, participants are asked to identify whether strings of letters are words or non-words and response latencies are recorded. Sample results from a recent publication are presented as an example of the applications for the experimental manipulation of blood glucose and the lexical decision task measures.

The authors introduce a method for manipulating blood glucose and measuring resulting changes in cognitive accessibility of target words using a lexical decision task.

Kan Şekeri kurgulama ve Hedef Uyaranların Bilişsel erişilebilirlik Ölçme Sonuç Değişiklikler Bir Yöntem

Much research in social psychology has investigated the impact of bodily energy need on cognition and decision-making.  As such, blood glucose, the body's ...

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with pathological involvement of upper and lower motoneurons, subsequently leading to progressive loss of motor and speech abilities. In addition, cognitive functions are impaired in a subset of patients. To evaluate these potential deficits in severely physically impaired ALS patients, eye-tracking is a promising means to conduct cognitive tests. The present article focuses on how eye movements, an indirect means of communication for physically disabled patients, can be utilized to allow for detailed neuropsychological assessment. The requirements, in terms of oculomotor parameters that have to be met for sufficient eye-tracking in ALS patients are presented. The properties of stimuli, including type of neuropsychological tests and style of presentation, best suited to successfully assess cognitive functioning, are also described. Furthermore, recommendations regarding procedural requirements are provided. Overall, this methodology provides a reliable, easy to administer and fast approach for assessing cognitive deficits in patients who are unable to speak or write such as patients with severe ALS. The only confounding factor might be deficits in voluntary eye movement control in a subset of ALS patients.

Cognitive deficits are common in about one third of patients with amyotrophic lateral sclerosis, a neurological condition leading to progressive impairments in speech and movement abilities. To conduct cognitive tests in patients unable to speak or write a reliable and easy to administer eye-tracking paradigm was developed.

Eye-Tracking Kontrol Amyotrofik Lateral Skleroz Hastalarında Bilişsel Fonksiyonlar değerlendirin

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with pathological involvement of upper and lower motoneurons, subsequently leading to ...

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses

Collecting reliable behavioral data from toddlers and preschoolers is challenging. As a result, there are significant gaps in our understanding of human auditory development for these age groups. This paper describes an observer-based procedure for measuring hearing sensitivity with a two-interval, two-alternative forced-choice paradigm. Young children are trained to perform a play-based, motor response (e.g., putting a block in a bucket) whenever they hear a target signal. An experimenter observes the child&#39;s behavior and makes a judgment about whether the signal was presented during the first or second observation interval; the experimenter is blinded to the true signal interval, so this judgment is based solely on the child&#39;s behavior. These procedures were used to test 2 to 4 year-olds (n = 33) with no known hearing problems. The signal was a 1,000 Hz warble tone presented in quiet, and the signal level was adjusted to estimate a threshold corresponding to 71%-correct detection. A valid threshold was obtained for 82% of children. These results indicate that the two-interval procedure is both feasible and reliable for use with toddlers and preschoolers. The two-interval, observer-based procedure described in this paper is a powerful tool for evaluating hearing in young children because it guards against response bias on the part of the experimenter.

This paper describes a procedure for measuring hearing sensitivity in 2 to 4 year-old children. Children are trained to perform play-based responses when they hear a target signal. Thresholds are then estimated in a two-interval, two-alternative forced-choice paradigm, based on observations of the child&#39;s behaviors.

4 Yaşındaki Çocuklara 2&#39;de İşitme Davranışsal Değerlendirme: A İki aralık, Gözlemci tabanlı Prosedür Koúullanmıú Play-tabanlı Yanıtları kullanma

Collecting reliable behavioral data from toddlers and preschoolers is challenging. As a result, there are significant gaps in our understanding of human ...