Formation of Thioether Linker by On-Resin Cyclization
5:29
Thioether Linker Formation via Intermolecular Thio-ene Reaction and Peptide Cyclization via Macrolactamization
7:02
Solution-Phase Formation of a Vinyl Sulfide Linker
8:41
Results: Thioether- and Vinyl Sulfide-Tethered Cyclic Peptides
10:42
Conclusion
Transkript
These methods simplify the generation of thioether-tethered cyclic peptides due to the use of the thio-ene or thio-yne click chemistry that possesses superior functional group tolerance and good yield. The main advantage of this technique is that
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We present a protocol for the construction of thioether/vinyl sulfide-tethered helical peptides using photo-induced thiol-ene/thiol-yne hydrothiolation.